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Tktl2 Gene Detail
Summary
  • Symbol
    Tktl2
  • Name
    transketolase-like 2
  • Synonyms
    4933401I19Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1921669
    NCBI Gene: 74419
  • Gene Overview
    MyGene.info: TKTL2
Location & Maps
more
  • Sequence Map
    Chr8:66511756-66518335 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      6580 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 33.14 cM, cytoband B3.3
  • Detailed Genetic Map ± 1 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    TKTL2, transketolase-like 2
  • Vertebrate Orthologs
    8
  • Human Ortholog
    TKTL2, transketolase-like 2
    Orthology source: HGNC, HomoloGene
  • Links
    NCBI Gene ID: 84076
    neXtProt AC: NX_Q9H0I9

  • Chr Location
    4q32.2; chr4:163471095-163473895 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotype references
  • All Mutations and Alleles
    1
  • Chemically induced (other)
    1
  • Genomic Mutations
    1 involving Tktl2
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000043647 VEGA Gene Model | MGI Sequence Detail 6580 C57BL/6J ±  kb
transcript OTTMUST00000114634 VEGA | MGI Sequence Detail 2021 Not Applicable  
polypeptide OTTMUSP00000063980 VEGA | MGI Sequence Detail 627 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    153 from dbSNP Build 142
Protein
Information
less
  • UniProt
    2 Sequences
  • EC
  • InterPro Domains
    IPR029061 Thiamin diphosphate-binding fold
    IPR020826 Transketolase binding site
    IPR033248 Transketolase, C-terminal domain
    IPR009014 Transketolase C-terminal/Pyruvate-ferredoxin oxidoreductase domain II
    IPR033247 Transketolase family
    IPR005475 Transketolase-like, pyrimidine-binding domain
    IPR005474 Transketolase, N-terminal
Molecular
Reagents
less
  • All nucleic 5
    cDNA 5

    Microarray probesets 2
References
more
  • Summaries
    All 20
    Developmental Gene Expression 1
    Gene Ontology 4
    Phenotypes 2
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/24/2016
MGI 6.04
The Jackson Laboratory