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Ttc25 Gene Detail
Summary
  • Symbol
    Ttc25
  • Name
    tetratricopeptide repeat domain 25
  • Synonyms
    4933404O19Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1921657
    NCBI Gene: 74407
  • Gene Overview
    MyGene.info: TTC25
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:100545632-100572566 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 63.47 cM, cytoband D
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    134 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1921657
protein coding gene Chr11:100545607-100572568 (.)
129S1/SvImJ MGP_129S1SvImJ_G0019159
protein coding gene Chr11:103306729-103333507 (+)
A/J MGP_AJ_G0019127
protein coding gene Chr11:98995646-99023400 (+)
AKR/J MGP_AKRJ_G0019096
protein coding gene Chr11:102055212-102083969 (+)
BALB/cJ MGP_BALBcJ_G0019101
protein coding gene Chr11:99475234-99505690 (+)
C3H/HeJ MGP_C3HHeJ_G0018910
protein coding gene Chr11:102241467-102270359 (+)
C57BL/6NJ MGP_C57BL6NJ_G0019550
protein coding gene Chr11:106520026-106551139 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017176
protein coding gene Chr11:96415172-96442608 (+)
CAST/EiJ MGP_CASTEiJ_G0018464
protein coding gene Chr11:103220137-103247021 (+)
CBA/J MGP_CBAJ_G0018879
protein coding gene Chr11:110949419-110982776 (+)
DBA/2J MGP_DBA2J_G0018991
protein coding gene Chr11:98534048-98560198 (+)
FVB/NJ MGP_FVBNJ_G0018981
protein coding gene Chr11:98068355-98095811 (+)
LP/J MGP_LPJ_G0019060
protein coding gene Chr11:103861220-103897429 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019012
protein coding gene Chr11:110553539-110585703 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0019588
protein coding gene Chr11:102388888-102491772 (+)
PWK/PhJ MGP_PWKPhJ_G0018227
protein coding gene Chr11:99573280-99600173 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018019
protein coding gene Chr11:102123884-102152949 (+)
WSB/EiJ MGP_WSBEiJ_G0018513
protein coding gene Chr11:102373260-102401433 (+)



Homology
more
  • Human Ortholog
    TTC25, tetratricopeptide repeat domain 25
  • Vertebrate Orthologs
    11
  • Human Ortholog
    TTC25, tetratricopeptide repeat domain 25
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 83538
    neXtProt AC: NX_Q96NG3
    UniProt: Q96NG3

  • Chr Location
    17q21.2; chr17:41930605-41966517 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 12860
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;2 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: TTC25
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with Ttc25 mouse models; 1 with human TTC25 associations

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 1 allele in 1 genetic background
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele display partial preweaning lethality, impaired ciliary motility, and a variety of left-right body symmetry defects.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 74407 NCBI Gene Model | MGI Sequence Detail 26935 C57BL/6J ±  kb
    transcript NM_028918 RefSeq | MGI Sequence Detail 2842 C57BL/6  
    polypeptide Q9D4B2 UniProt | EBI | MGI Sequence Detail 624 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 23
      cDNA 22
      Other 1

      Microarray probesets 4
    References
    more
    • Summaries
      All 39
      Developmental Gene Expression 1
      Diseases 1
      Gene Ontology 4
      Phenotypes 12
    • Earliest
      J:50799 Liu P, et al., Embryonic lethality and tumorigenesis caused by segmental aneuploidy on mouse chromosome 11. Genetics. 1998 Nov;150(3):1155-68
    • Latest
      J:244361 Wallmeier J, et al., TTC25 Deficiency Results in Defects of the Outer Dynein Arm Docking Machinery and Primary Ciliary Dyskinesia with Left-Right Body Asymmetry Randomization. Am J Hum Genet. 2016 Aug 04;99(2):460-9

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    Funding Information
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory