Epcip MGI Mouse Gene Detail - MGI:1921637 - exosomal polycystin 1 interacting protein

Symbol

Epcip
Name

exosomal polycystin 1 interacting protein
Synonyms

4932438H23Rik

Feature Type

protein coding gene
IDs

MGI:1921637
NCBI Gene: 74387
Alliance

gene page
Transcription Start Sites

12 TSS

Sequence Map

Chr16:90841534-90866040 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 16, 52.35 cM
Mapping Data

2 experiments

SNPs within 2kb

945 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1921637	protein coding gene	Chr16:90841534-90892010 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0023034	protein coding gene	Chr16:92035506-92078930 (-)
A/J	MGP_AJ_G0023002	protein coding gene	Chr16:87743985-87785141 (-)
AKR/J	MGP_AKRJ_G0022972	protein coding gene	Chr16:90383291-90425405 (-)
BALB/cJ	MGP_BALBcJ_G0023004	protein coding gene	Chr16:88264278-88304548 (-)
C3H/HeJ	MGP_C3HHeJ_G0022765	protein coding gene	Chr16:90950067-90991420 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0023451	protein coding gene	Chr16:95018522-95060326 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020953	protein coding gene	Chr16:85449657-85491898 (-)
CAST/EiJ	MGP_CASTEiJ_G0022284	protein coding gene	Chr16:91502473-91546128 (-)
CBA/J	MGP_CBAJ_G0022734	protein coding gene	Chr16:99075007-99123138 (-)
DBA/2J	MGP_DBA2J_G0022868	protein coding gene	Chr16:87643379-87685419 (-)
FVB/NJ	MGP_FVBNJ_G0022842	protein coding gene	Chr16:86773326-86813309 (-)
LP/J	MGP_LPJ_G0022938	protein coding gene	Chr16:91731053-91794861 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0022863	protein coding gene	Chr16:103639752-103695354 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0023469	protein coding gene	Chr16:90895288-90939118 (-)
PWK/PhJ	MGP_PWKPhJ_G0022029	protein coding gene	Chr16:87816513-87859629 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0021859	protein coding gene	Chr16:90459499-90503217 (-)
WSB/EiJ	MGP_WSBEiJ_G0022336	protein coding gene	Chr16:91141313-91185201 (-)

Human Ortholog

EPCIP, exosomal polycystin 1 interacting protein

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

EPCIP, exosomal polycystin 1 interacting protein
Synonyms

B37, C21orf120, C21orf62, CU062, PRED81
Links

HGNC:1305

NCBI Gene ID: 56245

UniProt: Q9NYP8
Chr Location

21q22.11; chr21:32790673-32813743 (-) GRCh38

MGI Vertebrate Homology

Epcip stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: EPCIP
Gene Tree

Epcip

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References

4 with disease annotations

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
77 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

12
Gene trapped

1
Spontaneous

1
Targeted

9
Genomic Mutations

8 involving Epcip
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

20 strains or lines available

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All GO Annotations

16
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

938
Tissues

159
cDNA Data

5
Literature Summary

4

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

45
RefSeq

12
UniProt

2
CCDS

CCDS28322.1

Ensembl

ENSMUSG00000039851 (Evidence)
NCBI Gene

74387

			Length	Strain/Species	Flank
genomic	74387	NCBI Gene Model \| MGI Sequence Detail	24507	C57BL/6J	± kb
transcript	NM_028905	RefSeq \| MGI Sequence Detail	1106	C57BL/6
polypeptide	Q9D4G1	UniProt \| EBI \| MGI Sequence Detail	230	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000060121 exosomal polycystin-1-interacting protein

(term hierarchy)
InterPro Domains

IPR029250 Exosomal polycystin-1-interacting protein
GlyGen

Q9D4G1 4 sites

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All nucleic 9

cDNA 6

Primer pair 2

Other 1

Microarray probesets 3

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MGI:2146457, MGI:7562016

Summaries

All 105

Developmental Gene Expression 4

Diseases 4

Gene Ontology 6

Phenotypes 77
Earliest

J:42265 Huang TT, et al., Superoxide-mediated cytotoxicity in superoxide dismutase-deficient fetal fibroblasts. Arch Biochem Biophys. 1997 Aug 15;344(2):424-32
Latest

J:361105 Tateossian H, et al., DYRK1A kinase triplication is the major cause of Otitis Media in Down Syndrome. Elife. 2025;

TSS for Epcip:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr142075	Chr16:90866054-90866080 (-)	-27 bp
Tssr142074	Chr16:90866030-90866047 (-)	1 bp
Tssr142073	Chr16:90866014-90866027 (-)	19 bp
Tssr142072	Chr16:90865983-90865994 (-)	51 bp
Tssr142071	Chr16:90860735-90860756 (-)	5,294 bp
Tssr142070	Chr16:90860705-90860732 (-)	5,321 bp
Tssr142069	Chr16:90858474-90858489 (-)	7,558 bp
Tssr142068	Chr16:90858448-90858467 (-)	7,582 bp
Tssr142067	Chr16:90853390-90853401 (-)	12,644 bp
Tssr142066	Chr16:90853329-90853348 (-)	12,701 bp
Tssr4953	Chr16:90853313-90853320 (-)	12,723 bp
Tssr142065	Chr16:90853298-90853309 (-)	12,736 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 03/18/2025 MGI 6.24