About   Help   FAQ
Rmi1 Gene Detail
Summary
  • Symbol
    Rmi1
  • Name
    RecQ mediated genome instability 1
  • Synonyms
    4932432N11Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1921636
    NCBI Gene: 74386
  • Gene Overview
    MyGene.info: RMI1
Location & Maps
more
  • Sequence Map
    Chr13:58402597-58411149 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      8553 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 13, 31.05 cM, cytoband B2
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    RMI1, RecQ mediated genome instability 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    RMI1, RecQ mediated genome instability 1
    Orthology source: HomoloGene
  • Synonyms
    BLAP75, C9orf76, FAAP75
  • Links
    NCBI Gene ID: 80010
    neXtProt AC: NX_Q9H9A7

  • Chr Location
    9q21.32; chr9:83980720-84004074 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 41601
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: RMI1
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 1 allele in 1 genetic background
    8 phenotypes from multigenic genotypes
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    17
  • Chemically induced (other)
    1
  • Gene trapped
    16
  • Genomic Mutations
    1 involving Rmi1
  • Incidental Mutations
    APF , CvDC
Mice homozygous for a gene trapped allele exhibit decreased weight and increased resistance to diet-induced obesity.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000035367 Ensembl Gene Model | MGI Sequence Detail 8553 C57BL/6J ±  kb
transcript ENSMUST00000042450 Ensembl | MGI Sequence Detail 3522 Not Applicable  
polypeptide ENSMUSP00000041035 Ensembl | MGI Sequence Detail 616 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    39 from dbSNP Build 142
Protein
Information
less
  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000014036 RecQ-mediated genome instability protein 1
  • InterPro Domains
    IPR032199 Recq-mediated genome instability protein 1, C-terminal OB-fold domain
    IPR033472 RecQ mediated genome instability protein, DUF1767
    IPR013894 RecQ mediated genome instability protein, N-terminal
Molecular
Reagents
less
  • All nucleic 47
    cDNA 47

    Microarray probesets 6
Other
Accession IDs
less
MGI:2145511
References
more
  • Summaries
    All 29
    Gene Ontology 4
    Phenotypes 8
  • Earliest
    J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-le-grand). 1999 Jul;45(5):737-50
  • Latest
    J:168271 Suwa A, et al., RMI1 deficiency in mice protects from diet and genetic-induced obesity. FEBS J. 2010 Feb;277(3):677-86

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
06/22/2016
MGI 6.04
The Jackson Laboratory