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Hsf2bp Gene Detail
Summary
  • Symbol
    Hsf2bp
  • Name
    heat shock transcription factor 2 binding protein
  • Synonyms
    4932437G14Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1921627
    NCBI Gene: 74377
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:32163743-32253869 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 17.25 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    411 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1921627
protein coding gene Chr17:32163743-32255323 (-)
129S1/SvImJ MGP_129S1SvImJ_G0023496
protein coding gene Chr17:31755608-31849174 (-)
A/J MGP_AJ_G0023453
protein coding gene Chr17:30707981-30800696 (-)
AKR/J MGP_AKRJ_G0023419
protein coding gene Chr17:30981411-31068326 (-)
BALB/cJ MGP_BALBcJ_G0023458
protein coding gene Chr17:30782090-30890764 (-)
C3H/HeJ MGP_C3HHeJ_G0023220
protein coding gene Chr17:31354172-31444809 (-)
C57BL/6NJ MGP_C57BL6NJ_G0023901
protein coding gene Chr17:32858952-32946469 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021375
protein coding gene Chr17:27825334-27906750 (-)
CAST/EiJ MGP_CASTEiJ_G0022721
protein coding gene Chr17:31431999-31508119 (-)
CBA/J MGP_CBAJ_G0023195
protein coding gene Chr17:34257536-34359425 (-)
DBA/2J MGP_DBA2J_G0023325
protein coding gene Chr17:30093488-30179414 (-)
FVB/NJ MGP_FVBNJ_G0023295
protein coding gene Chr17:29912610-30001659 (-)
LP/J MGP_LPJ_G0023403
protein coding gene Chr17:31965447-32058525 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0023313
protein coding gene Chr17:33344614-33433977 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0023943
protein coding gene Chr17:31345675-31430449 (-)
PWK/PhJ MGP_PWKPhJ_G0022470
protein coding gene Chr17:28970473-29060884 (-)
SPRET/EiJ MGP_SPRETEiJ_G0022289
protein coding gene Chr17:29329355-29426813 (-)
WSB/EiJ MGP_WSBEiJ_G0022783
protein coding gene Chr17:31317278-31404775 (-)



Homology
more
  • Human Ortholog
    HSF2BP, heat shock transcription factor 2 binding protein
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HSF2BP, heat shock transcription factor 2 binding protein
  • Synonyms
    MEILB2, POF19
  • Links
    NCBI Gene ID: 11077
    neXtProt AC: NX_O75031
    UniProt: O75031

  • Chr Location
    21q22.3; chr21:43453987-43659499 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Hsf2bp mouse models; 1 with human HSF2BP associations

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    30 phenotypes from 5 alleles in 5 genetic backgrounds
    28 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous knockout affects double-stranded DNA break repair, resulting in abnormal meiosis, which in turn leads to male sterility. KO mice are born at lower than expected Mendelian ratio.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 74377 NCBI Gene Model | MGI Sequence Detail 90127 C57BL/6J ±  kb
    transcript NM_028902 RefSeq | MGI Sequence Detail 2867 C57BL/6  
    polypeptide Q9D4G2 UniProt | EBI | MGI Sequence Detail 338 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 18
      Genomic 1
      cDNA 14
      Primer pair 2
      Other 1

      Microarray probesets 6
    References
    more
    • Summaries
      All 57
      Developmental Gene Expression 8
      Diseases 3
      Gene Ontology 9
      Phenotypes 28
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:325094 Guan Y, et al., SCF ubiquitin E3 ligase regulates DNA double-strand breaks in early meiotic recombination. Nucleic Acids Res. 2022 May 20;50(9):5129-5144

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    last database update
    06/28/2022
    MGI 6.20
    The Jackson Laboratory