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Myo18b Gene Detail
Summary
  • Symbol
    Myo18b
  • Name
    myosin XVIIIb
  • Synonyms
    4932408L24Rik, 4933411E19Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1921626
    NCBI Gene: 74376
  • Gene Overview
    MyGene.info: MYO18B
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr5:112688876-112896362 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      207487 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 54.80 cM, cytoband F
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    MYO18B, myosin XVIIIB
  • Vertebrate Orthologs
    9
  • Human Ortholog
    MYO18B, myosin XVIIIB
    Orthology source: HomoloGene, HGNC
  • Synonyms
    KFS4
  • Links
    NCBI Gene ID: 84700
    neXtProt AC: NX_Q8IUG5
    UniProt: Q8IUG5

  • Chr Location
    22q12.1; chr22:25742133-26063847 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotypes from 1 allele in 1 genetic background
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null mutation display embryonic lethality during organogenesis with internal hemorrhage, pericaridal effusion, enlargement of the right atrium, and cardiac myofibril abnormalities.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000043204 VEGA Gene Model | MGI Sequence Detail 207487 C57BL/6J ±  kb
    transcript OTTMUST00000113309 VEGA | MGI Sequence Detail 8280 Not Applicable  
    polypeptide OTTMUSP00000063393 VEGA | MGI Sequence Detail 2605 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      1759 from dbSNP Build 142
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • InterPro Domains
      IPR036064 Class XVIII myosin, motor domain
      IPR000048 IQ motif, EF-hand binding site
      IPR036961 Kinesin motor domain superfamily
      IPR001609 Myosin head, motor domain
      IPR027401 Myosin IQ motif-containing domain superfamily
      IPR002928 Myosin tail
      IPR027417 P-loop containing nucleoside triphosphate hydrolase
      IPR028561 Unconventional myosin-XVIIIb
    Molecular
    Reagents
    less
    • All nucleic 9
      Genomic 1
      cDNA 7
      Primer pair 1

      Microarray probesets 18
    Other
    Accession IDs
    less
    MGI:2685294
    References
    more
    • Summaries
      All 24
      Developmental Gene Expression 2
      Gene Ontology 2
      Phenotypes 6
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    05/15/2018
    MGI 6.12
    The Jackson Laboratory