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Lonrf3 Gene Detail
Summary
  • Symbol
    Lonrf3
  • Name
    LON peptidase N-terminal domain and ring finger 3
  • Synonyms
    4932412G04Rik, 5730439E01Rik, A830039N02Rik, Rnf127
  • Feature Type
    protein coding gene
  • IDs
    MGI:1921615
    NCBI Gene: 74365
Location & Maps
more
  • Sequence Map
    ChrX:36328353-36362341 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      33989 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome X, 20.72 cM, cytoband A2
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    LONRF3, LON peptidase N-terminal domain and ring finger 3
  • Vertebrate Orthologs
    9
  • Human Ortholog
    LONRF3, LON peptidase N-terminal domain and ring finger 3
    Orthology source: HGNC, HomoloGene
  • Synonyms
    RNF127
  • Links
    NCBI Gene ID: 79836
    neXtProt AC: NX_Q496Y0

  • Chr Location
    Xq24; chrX:118974614-119018856 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    5 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    2
  • Targeted
    2
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000017249 VEGA Gene Model | MGI Sequence Detail 33989 C57BL/6J ±  kb
transcript OTTMUST00000041737 VEGA | MGI Sequence Detail 2911 Not Applicable  
polypeptide OTTMUSP00000018759 VEGA | MGI Sequence Detail 753 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    80 from dbSNP Build 142
Protein
Information
less
  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000031875 LON peptidase N-terminal domain and RING finger protein 3
  • InterPro Domains
    IPR003111 ATP-dependent protease La (LON), substrate-binding domain
    IPR015947 PUA-like domain
    IPR027370 RING-type zinc-finger, LisH dimerisation motif
    IPR011990 Tetratricopeptide-like helical domain
    IPR019734 Tetratricopeptide repeat
    IPR013026 Tetratricopeptide repeat-containing domain
    IPR013083 Zinc finger, RING/FYVE/PHD-type
    IPR001841 Zinc finger, RING-type
    IPR017907 Zinc finger, RING-type, conserved site
Molecular
Reagents
less
  • All nucleic 34
    cDNA 34

    Microarray probesets 4
Other
Accession IDs
less
MGI:1917784, MGI:2147971
References
more
  • Summaries
    All 34
    Developmental Gene Expression 2
    Gene Ontology 2
    Phenotypes 5
  • Earliest
    J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
  • Latest
    J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory