Lonrf3 MGI Mouse Gene Detail - MGI:1921615 - LON peptidase N-terminal domain and ring finger 3

Symbol

Lonrf3
Name

LON peptidase N-terminal domain and ring finger 3
Synonyms

4932412G04Rik, 5730439E01Rik, A830039N02Rik, Rnf127

Feature Type

protein coding gene
IDs

MGI:1921615
NCBI Gene: 74365
Alliance

genome feature page
Transcription Start Sites

5 TSS

Sequence Map

ChrX:35592006-35625994 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome X, 20.72 cM, cytoband A2
Mapping Data

3 experiments

SNPs within 2kb

584 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1921615	protein coding gene	ChrX:35592006-35630510 (+)
129S1/SvImJ	ENSMUSG00200015221	protein coding gene	ChrX:19691855-19739864 (+)
A/J	ENSMUSG00195025056	protein coding gene	ChrX:22363940-22411942 (+)
AKR/J	ENSMUSG00220017707	protein coding gene	ChrX:19476190-19524189 (+)
BALB/cJ	ENSMUSG00180021713	protein coding gene	ChrX:19922278-19970276 (+)
C3H/HeJ	ENSMUSG00175022509	protein coding gene	ChrX:23064479-23112474 (+)
C57BL/6NJ	ENSMUSG00215014275	protein coding gene	ChrX:20116273-20164267 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0032986	protein coding gene	ChrX:29467185-29503124 (+)
CAST/EiJ	ENSTCUG00005032809	protein coding gene	ChrX:21997756-22045766 (+)
CBA/J	ENSMUSG00210031987	protein coding gene	ChrX:20358235-20406235 (+)
DBA/2J	ENSMUSG00185023833	protein coding gene	ChrX:30941283-30989279 (+)
FVB/NJ	ENSMUSG00205022518	protein coding gene	ChrX:19040596-19088610 (+)
JF1/MsJ	ENSUMUG00000022792	protein coding gene	ChrX:50069314-50118027 (+)
LP/J	ENSMUSG00230012979	protein coding gene	ChrX:37433593-37481587 (+)
NOD/ShiLtJ	ENSMUSG00190025083	protein coding gene	ChrX:19630887-19678880 (+)
NZO/HlLtJ	ENSMUSG00225038490	protein coding gene	ChrX:42639973-42687964 (+)
PWK/PhJ	ENSLUMG00010015750	protein coding gene	ChrX:19777563-19826329 (+)
SPRET/EiJ	ENSMSPG00010015178	protein coding gene	ChrX:21004379-21045822 (+)
WSB/EiJ	ENSIUOG00005036019	protein coding gene	ChrX:20550796-20598812 (+)

Human Ortholog

LONRF3, LON peptidase N-terminal domain and ring finger 3

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

LONRF3, LON peptidase N-terminal domain and ring finger 3
Synonyms

RNF127
Links

HGNC:21152

NCBI Gene ID: 79836

UniProt: Q496Y0
Chr Location

Xq24; chrX:118974614-119022925 (+) GRCh38

MGI Vertebrate Homology

Lonrf3 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: LONRF3
Gene Tree

Lonrf3

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Phenotype Summary

3 phenotypes from 1 allele in 1 genetic background
9 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Endonuclease-mediated

5
Targeted

2
Incidental Mutations

CvDC
Find Mice (IMSR)

9 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

2
GO References

2

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

632
Tissues

17
cDNA Data

33
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase lonrf3

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All Sequences

48
RefSeq

4
UniProt

2
CCDS

CCDS30059.1

Ensembl

ENSMUSG00000016239 (Evidence)
NCBI Gene

74365

			Length	Strain/Species	Flank
genomic	ENSMUSG00000016239	Ensembl Gene Model \| MGI Sequence Detail	33989	C57BL/6J	± kb
transcript	ENSMUST00000016383	Ensembl \| MGI Sequence Detail	2911	Not Applicable
polypeptide	ENSMUSP00000016383	Ensembl \| MGI Sequence Detail	753	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000031875 LON peptidase N-terminal domain and RING finger protein 3

(term hierarchy)
InterPro Domains

IPR003111 Lon protease, N-terminal domain

IPR046336 Lon protease, N-terminal domain superfamily

IPR015947 PUA-like superfamily

IPR011990 Tetratricopeptide-like helical domain superfamily

IPR019734 Tetratricopeptide repeat

IPR018957 Zinc finger, C3HC4 RING-type

IPR013083 Zinc finger, RING/FYVE/PHD-type

IPR001841 Zinc finger, RING-type

IPR017907 Zinc finger, RING-type, conserved site

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All nucleic 35

cDNA 35

Microarray probesets 4

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MGI:1917784, MGI:2147971

Summaries

All 40

Developmental Gene Expression 2

Gene Ontology 2

Phenotypes 9
Earliest

J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Lonrf3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr160739	ChrX:35592052-35592071 (+)	56 bp
Tssr160740	ChrX:35592073-35592094 (+)	78 bp
Tssr160741	ChrX:35600354-35600367 (+)	8,355 bp
Tssr160742	ChrX:35609857-35609863 (+)	17,854 bp
Tssr160743	ChrX:35614612-35614614 (+)	22,607 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/08/2026 MGI 6.24