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Spag17 Gene Detail
Summary
  • Symbol
    Spag17
  • Name
    sperm associated antigen 17
  • Synonyms
    4931427F14Rik, PF6
  • Feature Type
    protein coding gene
  • IDs
    MGI:1921612
    NCBI Gene: 74362
Location & Maps
more
  • Sequence Map
    Chr3:99885406-100143322 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      257917 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 43.25 cM, cytoband F3
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    SPAG17, sperm associated antigen 17
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SPAG17, sperm associated antigen 17
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CT143, PF6
  • Links
    NCBI Gene ID: 200162
    neXtProt AC: NX_Q6Q759

  • Chr Location
    1p12; chr1:117953665-118185225 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    21 phenotypes from 2 alleles in 1 genetic background
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    7
  • Chemically induced (other)
    1
  • Radiation induced
    1
  • Targeted
    5
  • Genomic Mutations
    2 involving Spag17
  • Incidental Mutations
Homozygous null mice exhibit immotile respiratory cilia with axoneme structural defects, impaired mucociliary clearance, respiratory distress, pulmonary edema, disrupted alveolar epithelium, enlarged brain ventricles consistent with evolving hydrocephalus, failure to suckle, and neonatal lethality.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000006935 VEGA Gene Model | MGI Sequence Detail 257917 C57BL/6J ±  kb
transcript OTTMUST00000096035 VEGA | MGI Sequence Detail 7862 Not Applicable  
polypeptide OTTMUSP00000053618 VEGA | MGI Sequence Detail 2320 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    1898 from dbSNP Build 142
Protein
Information
less
  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000015456 sperm-associated antigen 17
  • InterPro Domains
    IPR026173 Sperm-associated antigen 17
Molecular
Reagents
less
  • All nucleic 5
    cDNA 5

    Microarray probesets 4
References
more
  • Summaries
    All 25
    Gene Ontology 4
    Phenotypes 8
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:229435 Teves ME, et al., Spag17 deficiency results in skeletal malformations and bone abnormalities. PLoS One. 2015;10(5):e0125936

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/12/2016
MGI 6.04
The Jackson Laboratory