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Matcap1 Gene Detail
Summary
  • Symbol
    Matcap1
  • Name
    microtubule associated tyrosine carboxypeptidase 1
  • Synonyms
    4931428F04Rik, MATCAP
  • Feature Type
    protein coding gene
  • IDs
    MGI:1921606
    NCBI Gene: 74356
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:106007041-106016160 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 53.04 cM, cytoband D1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    276 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1921606
 protein coding gene Chr8:106007041-106016496 (-)
129S1/SvImJ MGP_129S1SvImJ_G0034035
 protein coding gene Chr8:107545727-107554747 (-)
A/J MGP_AJ_G0034016
 protein coding gene Chr8:103258369-103267201 (-)
AKR/J MGP_AKRJ_G0033942
 protein coding gene Chr8:106242378-106251155 (-)
BALB/cJ MGP_BALBcJ_G0034009
 protein coding gene Chr8:103433527-103443782 (-)
C3H/HeJ MGP_C3HHeJ_G0033721
 protein coding gene Chr8:106988238-106998485 (-)
C57BL/6NJ MGP_C57BL6NJ_G0034529
 protein coding gene Chr8:111494928-111503973 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031471
 protein coding gene Chr8:96407833-96416669 (-)
CAST/EiJ MGP_CASTEiJ_G0033047
 protein coding gene Chr8:106487182-106497598 (-)
CBA/J MGP_CBAJ_G0033694
 protein coding gene Chr8:115092301-115101239 (-)
DBA/2J MGP_DBA2J_G0033849
 protein coding gene Chr8:102603301-102612275 (-)
FVB/NJ MGP_FVBNJ_G0033795
 protein coding gene Chr8:101526584-101536269 (-)
LP/J MGP_LPJ_G0033940
 protein coding gene Chr8:107756852-107765667 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0033838
 protein coding gene Chr8:118305124-118316729 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0034547
 protein coding gene Chr8:106216364-106226155 (-)
PWK/PhJ MGP_PWKPhJ_G0032748
 protein coding gene Chr8:101988131-101998761 (-)
SPRET/EiJ MGP_SPRETEiJ_G0032589
 protein coding gene Chr8:104893487-104902924 (-)
WSB/EiJ MGP_WSBEiJ_G0033163
 protein coding gene Chr8:106869465-106879560 (-)



Homology
more
  • Human Ortholog
    MATCAP1, microtubule associated tyrosine carboxypeptidase 1
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MATCAP1, microtubule associated tyrosine carboxypeptidase 1
  • Synonyms
    KIAA0895L, TMCP1
  • Links
    NCBI Gene ID: 653319
    UniProt: Q68EN5

  • Chr Location
    16q22.1; chr16:67175599-67184040 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    5 phenotypes from multigenic genotypes
    5 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit reduced brain size.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    19
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    716
  • Tissues
    9
  • cDNA Data
    8
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 74356 NCBI Gene Model | MGI Sequence Detail 9120 C57BL/6J ±  kb
    transcript NM_028888 RefSeq | MGI Sequence Detail 3571 C57BL/6  
    polypeptide Q810A5 UniProt | EBI | MGI Sequence Detail 467 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 9
      cDNA 8
      Primer pair 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:2142530, MGI:7388463
    References
    more
    • Summaries
      All 32
      Developmental Gene Expression 1
      Gene Ontology 6
      Phenotypes 5
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:325393 Landskron L, et al., Posttranslational modification of microtubules by the MATCAP detyrosinase. Science. 2022 May 20;376(6595):eabn6020
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    03/18/2025
    MGI 6.24     		The Jackson Laboratory