About   Help   FAQ
Lrguk Gene Detail
Summary
  • Symbol
    Lrguk
  • Name
    leucine-rich repeats and guanylate kinase domain containing
  • Synonyms
    4921528H16Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1921604
    NCBI Gene: 74354
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:34029448-34134034 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 14.75 cM, cytoband B1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    526 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1921604
protein coding gene Chr6:34029245-34134034 (+)
129S1/SvImJ MGP_129S1SvImJ_G0030554
protein coding gene Chr6:32084520-32197154 (+)
A/J MGP_AJ_G0030527
protein coding gene Chr6:30720522-30827403 (+)
AKR/J MGP_AKRJ_G0030454
protein coding gene Chr6:31743769-31853493 (+)
BALB/cJ MGP_BALBcJ_G0030537
protein coding gene Chr6:30902168-31007492 (+)
C3H/HeJ MGP_C3HHeJ_G0030250
protein coding gene Chr6:31716676-31825006 (+)
C57BL/6NJ MGP_C57BL6NJ_G0030991
protein coding gene Chr6:32899431-33008513 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028202
protein coding gene Chr6:28812319-28916664 (+)
CAST/EiJ MGP_CASTEiJ_G0029652
protein coding gene Chr6:31513358-31626051 (+)
CBA/J MGP_CBAJ_G0030228
protein coding gene Chr6:34162644-34284792 (+)
DBA/2J MGP_DBA2J_G0030372
protein coding gene Chr6:30597795-30702784 (+)
FVB/NJ MGP_FVBNJ_G0030326
protein coding gene Chr6:30379388-30482994 (+)
LP/J MGP_LPJ_G0030459
protein coding gene Chr6:32212783-32321091 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0030362
protein coding gene Chr6:36532334-36643732 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0031021
protein coding gene Chr6:31636906-31744488 (+)
PWK/PhJ MGP_PWKPhJ_G0029366
protein coding gene Chr6:30197246-30305398 (+)
SPRET/EiJ MGP_SPRETEiJ_G0029202
protein coding gene Chr6:31266117-31381943 (+)
WSB/EiJ MGP_WSBEiJ_G0029728
protein coding gene Chr6:31550325-31659530 (+)



Homology
more
  • Human Ortholog
    LRGUK, leucine rich repeats and guanylate kinase domain containing
  • Vertebrate Orthologs
    10
  • Human Ortholog
    LRGUK, leucine rich repeats and guanylate kinase domain containing
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CFAP246
  • Links
    NCBI Gene ID: 136332
    neXtProt AC: NX_Q96M69
    UniProt: Q96M69

  • Chr Location
    7q33; chr7:134127352-134264181 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 34923
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: LRGUK
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    17 phenotypes from 1 allele in 1 genetic background
    4 images
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for an ENU-induced hypomorphic allele exhibit male infertility associated with oligoasthenoteratospermia and defects in acrosome attachment, manchette structure and function, sperm head shaping, and sperm tail axoneme extension.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000056215 Ensembl Gene Model | MGI Sequence Detail 104587 C57BL/6J ±  kb
    transcript ENSMUST00000228187 Ensembl | MGI Sequence Detail 10475 Not Applicable  
    polypeptide ENSMUSP00000153993 Ensembl | MGI Sequence Detail 1340 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • Protein Ontology
      PR:000029121 leucine-rich repeat and guanylate kinase domain-containing protein
    • InterPro Domains
      IPR008144 Guanylate kinase-like domain
      IPR008145 Guanylate kinase/L-type calcium channel beta subunit
      IPR001611 Leucine-rich repeat
      IPR032675 Leucine-rich repeat domain superfamily
      IPR027417 P-loop containing nucleoside triphosphate hydrolase
    Molecular
    Reagents
    less
    • All nucleic 5
      cDNA 5

      Microarray probesets 2
    References
    more
    • Summaries
      All 25
      Developmental Gene Expression 1
      Gene Ontology 3
      Phenotypes 6
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:222840 Liu Y, et al., LRGUK-1 is required for basal body and manchette function during spermatogenesis and male fertility. PLoS Genet. 2015 Mar;11(3):e1005090

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer & Copyright Notice
    Send questions and comments to User Support.
    last database update
    12/03/2019
    MGI 6.14
    The Jackson Laboratory