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Xrcc3 Gene Detail
Summary
  • Symbol
    Xrcc3
  • Name
    X-ray repair complementing defective repair in Chinese hamster cells 3
  • Synonyms
    4432412E01Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1921585
    NCBI Gene: 74335
  • Gene Overview
    MyGene.info: XRCC3
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:111803192-111813873 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 12, 61.14 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    171 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1921585
protein coding gene Chr12:111803192-111813879 (-)
129S1/SvImJ MGP_129S1SvImJ_G0020142
protein coding gene Chr12:114222009-114234191 (-)
A/J MGP_AJ_G0020098
protein coding gene Chr12:109831566-109842097 (-)
AKR/J MGP_AKRJ_G0020073
protein coding gene Chr12:112979840-112990371 (-)
BALB/cJ MGP_BALBcJ_G0020083
protein coding gene Chr12:110250850-110261575 (-)
C3H/HeJ MGP_C3HHeJ_G0019885
protein coding gene Chr12:113479248-113489779 (-)
C57BL/6NJ MGP_C57BL6NJ_G0020528
protein coding gene Chr12:117770038-117782433 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018141
protein coding gene Chr12:106264368-106274860 (-)
CAST/EiJ MGP_CASTEiJ_G0019426
protein coding gene Chr12:108331055-108341699 (-)
CBA/J MGP_CBAJ_G0019852
protein coding gene Chr12:122266341-122279911 (-)
DBA/2J MGP_DBA2J_G0019969
protein coding gene Chr12:109306952-109317483 (-)
FVB/NJ MGP_FVBNJ_G0019954
protein coding gene Chr12:108115527-108126055 (-)
LP/J MGP_LPJ_G0020044
protein coding gene Chr12:114050770-114062649 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0019992
protein coding gene Chr12:125372565-125384435 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0020557
protein coding gene Chr12:112501185-112512742 (-)
PWK/PhJ MGP_PWKPhJ_G0019187
protein coding gene Chr12:103953976-103965443 (-)
SPRET/EiJ MGP_SPRETEiJ_G0018990
protein coding gene Chr12:106664669-106675229 (-)
WSB/EiJ MGP_WSBEiJ_G0019485
protein coding gene Chr12:113408408-113418979 (-)



Homology
more
  • Human Ortholog
    XRCC3, X-ray repair cross complementing 3
  • Vertebrate Orthologs
    10
  • Human Ortholog
    XRCC3, X-ray repair cross complementing 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CMM6
  • Links
    NCBI Gene ID: 7517
    neXtProt AC: NX_O43542
    UniProt: O43542

  • Chr Location
    14q32.33; chr14:103697611-103715486 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    2 with human XRCC3 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000021287 Ensembl Gene Model | MGI Sequence Detail 10682 C57BL/6J ±  kb
transcript ENSMUST00000021715 Ensembl | MGI Sequence Detail 2422 Not Applicable  
polypeptide ENSMUSP00000021715 Ensembl | MGI Sequence Detail 349 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000017506 DNA repair protein XRCC3
  • InterPro Domains
    IPR013632 DNA recombination and repair protein Rad51-like, C-terminal
    IPR016467 DNA recombination and repair protein, RecA-like
    IPR020588 DNA recombination and repair protein RecA-like, ATP-binding domain
    IPR027417 P-loop containing nucleoside triphosphate hydrolase
    IPR033925 Rad51/DMC1/RadA
Molecular
Reagents
less
  • All nucleic 22
    cDNA 22

    Microarray probesets 4
Other
Accession IDs
less
MGI:2144770, MGI:2145034
References
more
  • Summaries
    All 32
    Developmental Gene Expression 2
    Gene Ontology 5
    Phenotypes 6
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:236599 Dickinson ME, et al., High-throughput discovery of novel developmental phenotypes. Nature. 2016 Sep 14;537(7621):508-514

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory