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Xrcc3 Gene Detail
Summary
  • Symbol
    Xrcc3
  • Name
    X-ray repair complementing defective repair in Chinese hamster cells 3
  • Synonyms
    4432412E01Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1921585
    NCBI Gene: 74335
  • Gene Overview
    MyGene.info: XRCC3
Location & Maps
more
  • Sequence Map
    Chr12:111803192-111813873 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      10682 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 12, 61.14 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    XRCC3, X-ray repair cross complementing 3
  • Vertebrate Orthologs
    10
  • Human Ortholog
    XRCC3, X-ray repair cross complementing 3
    Orthology source: HomoloGene
  • Synonyms
    CMM6
  • Links
    NCBI Gene ID: 7517
    neXtProt AC: NX_O43542

  • Chr Location
    14q32.3; chr14:103697608-103715486 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    2 with human XRCC3 associations

Human Disease Mouse Models
       Breast Cancer   OMIM: 114480
Melanoma, Cutaneous Malignant, Susceptibility to, 6; CMM6   OMIM: 613972
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    5 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    6
  • Gene trapped
    3
  • Targeted
    3
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000027508 VEGA Gene Model | MGI Sequence Detail 10682 C57BL/6J ±  kb
transcript OTTMUST00000068090 VEGA | MGI Sequence Detail 2422 Not Applicable  
polypeptide OTTMUSP00000034360 VEGA | MGI Sequence Detail 349 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    171 from dbSNP Build 142
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000017506 DNA repair protein XRCC3
  • InterPro Domains
    IPR013632 DNA recombination and repair protein Rad51, C-terminal
    IPR016467 DNA recombination and repair protein, RecA-like
    IPR020588 DNA recombination and repair protein RecA-like, ATP-binding domain
    IPR027417 P-loop containing nucleoside triphosphate hydrolase
Molecular
Reagents
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  • All nucleic 21
    cDNA 21

    Microarray probesets 4
Other
Accession IDs
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MGI:2144770, MGI:2145034
References
more
  • Summaries
    All 30
    Developmental Gene Expression 2
    Gene Ontology 4
    Phenotypes 5
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:228563 Koscielny G, et al., The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Nucleic Acids Res. 2014 Jan;42(Database issue):D802-9

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory