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Ranbp10
Gene Detail
Symbol

Name
ID
Ranbp10
RAN binding protein 10
MGI:1921584
Synonyms
4432417N03Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 8
53.04 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr8:105768308-105827350 bp, - strand
From Ensembl annotation of GRCm38

  59043 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:49639  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

HCOP human homology predictions: RANBP10
Gene Tree: Ranbp10

Human
homologs
RANBP10, RAN binding protein 10
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 57610
neXtProt AC: NX_Q6VN20

Human Chr (Location): 16q22.1; chr16:67723070-67806652 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Gene trapped(5) Targeted(3)
 
Mice homozygous for a gene trap allele exhibit slight defects in erythrocyte number and volume, decreased platelet aggregattion and increased bleeding time associated with impaired platelet dense granule release.
 
Interactions
Ranbp10 interacts with 367 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (8 annotations)
Process microtubule cytoskeleton organization, positive regulation of GTPase activity
Component cytoplasm, cytoplasmic microtubule, ...
Function beta-tubulin binding, Ran GTPase binding, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (34)    Tissues (10)    Images (24)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 24
RT-PCR 10
cDNA source data(106)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(107) cDNA(106) Primer pair(1)
Microarray probesets(4)
Other database
links
Ensembl Gene Model ENSMUSG00000037415 (Evidence)
Entrez Gene 74334 (Evidence)
UniGene 4206
DFCI TC1583092, TC1637254
DoTS DT.101223437, DT.531485, DT.94177553
Consensus CDS Project CCDS22613.1
International Mouse Phenotyping Consortium Status Ranbp10
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000037415 Ensembl Gene Model | MGI Sequence Detail 59043 C57BL/6J ±  kb
transcript ENSMUST00000041400 Ensembl | MGI Sequence Detail 5308 Not Applicable 
polypeptide ENSMUSP00000040045 Ensembl | MGI Sequence Detail 648 Not Applicable 

For the selected sequences
All sequences(35) RefSeq(14) UniProt(2)
Polymorphisms
SNPs within 2kb(195 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001870 B30.2/SPRY domain
InterPro IPR013320 Concanavalin A-like lectin/glucanase domain
InterPro IPR013144 CRA domain
InterPro IPR024964 CTLH/CRA C-terminal to LisH motif domain
InterPro IPR006595 CTLH, C-terminal LisH motif
InterPro IPR006594 LIS1 homology motif
InterPro IPR003877 SPRY domain
Protein Ontology PR:000013710 ran-binding protein 10
References
(Earliest) J:62506 Hemberger M, et al., cDNA subtraction cloning reveals novel genes whose temporal and spatial expression indicates association with trophoblast invasion. Dev Biol. 2000 Jun 1;222(1):158-69
(Latest) J:192924 Meyer I, et al., Altered microtubule equilibrium and impaired thrombus stability in mice lacking RanBP10. Blood. 2012 Oct 25;120(17):3594-602
All references(31)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory