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Inava Gene Detail
Summary
  • Symbol
    Inava
  • Name
    innate immunity activator
  • Synonyms
    1700034M08Rik, 5730559C18Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1921579
    NCBI Gene: 67313
  • Alliance
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:136141269-136162002 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 1, 59.61 cM, cytoband F
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    183 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1921579
protein coding gene Chr1:136141259-136162045 (-)
129S1/SvImJ MGP_129S1SvImJ_G0016538
protein coding gene Chr1:140029064-140049828 (-)
A/J MGP_AJ_G0016521
protein coding gene Chr1:134721532-134742253 (-)
AKR/J MGP_AKRJ_G0016486
protein coding gene Chr1:138726446-138747177 (-)
BALB/cJ MGP_BALBcJ_G0016481
protein coding gene Chr1:135050856-135072156 (-)
C3H/HeJ MGP_C3HHeJ_G0016307
protein coding gene Chr1:138822118-138842757 (-)
C57BL/6NJ MGP_C57BL6NJ_G0016942
protein coding gene Chr1:145048769-145069487 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014653
protein coding gene Chr1:127829169-127849845 (-)
CAST/EiJ MGP_CASTEiJ_G0015887
protein coding gene Chr1:137922657-137943372 (-)
CBA/J MGP_CBAJ_G0016280
protein coding gene Chr1:150071653-150092364 (-)
DBA/2J MGP_DBA2J_G0016386
protein coding gene Chr1:133715009-133735827 (-)
FVB/NJ MGP_FVBNJ_G0016385
protein coding gene Chr1:132363415-132384501 (-)
LP/J MGP_LPJ_G0016457
protein coding gene Chr1:141248806-141269563 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0016410
protein coding gene Chr1:155714632-155735384 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0016978
protein coding gene Chr1:138491267-138511850 (-)
PWK/PhJ MGP_PWKPhJ_G0015673
protein coding gene Chr1:132764463-132785488 (-)
SPRET/EiJ MGP_SPRETEiJ_G0015460
protein coding gene Chr1:137483553-137504122 (-)
WSB/EiJ MGP_WSBEiJ_G0015950
protein coding gene Chr1:138535288-138556053 (-)



Homology
more
  • Human Ortholog
    INAVA, innate immunity activator
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    INAVA, innate immunity activator
  • Synonyms
    C1orf106
  • Links
    NCBI Gene ID: 55765
    neXtProt AC: NX_Q3KP66
    UniProt: Q3KP66

  • Chr Location
    1q32.1; chr1:200891048-200915742 (+)  GRCh38

Human Diseases
more
  • Diseases
    1 with human INAVA associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 1 allele in 1 genetic background
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele have defects in the intestinal epithelial cell barrier and exhibit increased susceptibility to DSS-induced colitis and Citrobacter rodentium infection.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000041605 Ensembl Gene Model | MGI Sequence Detail 20734 C57BL/6J ±  kb
    transcript ENSMUST00000120339 Ensembl | MGI Sequence Detail 2988 Not Applicable  
    polypeptide ENSMUSP00000113785 Ensembl | MGI Sequence Detail 663 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 34
      Genomic 1
      cDNA 33

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1914563
    References
    more
    • Summaries
      All 36
      Developmental Gene Expression 1
      Gene Ontology 4
      Phenotypes 12
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:274872 Ingham NJ, et al., Mouse screen reveals multiple new genes underlying mouse and human hearing loss. PLoS Biol. 2019 Apr;17(4):e3000194

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    03/19/2024
    MGI 6.23
    The Jackson Laboratory