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Isca2 Gene Detail
Summary
  • Symbol
    Isca2
  • Name
    iron-sulfur cluster assembly 2
  • Synonyms
    0710001C05Rik, 5730594E03Rik, Hbld1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1921566
    NCBI Gene: 74316
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:84773251-84775088 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 12, 39.38 cM, cytoband D3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    14 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1921566
protein coding gene Chr12:84773229-84775089 (+)
129S1/SvImJ MGP_129S1SvImJ_G0019945
protein coding gene Chr12:85512228-85514047 (+)
A/J MGP_AJ_G0019902
protein coding gene Chr12:82271380-82273199 (+)
AKR/J MGP_AKRJ_G0019878
protein coding gene Chr12:84494895-84496714 (+)
BALB/cJ MGP_BALBcJ_G0019882
protein coding gene Chr12:82601964-82603783 (+)
C3H/HeJ MGP_C3HHeJ_G0019688
protein coding gene Chr12:84966976-84968795 (+)
C57BL/6NJ MGP_C57BL6NJ_G0020333
protein coding gene Chr12:87978279-87980098 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017951
protein coding gene Chr12:79159471-79161306 (+)
CAST/EiJ MGP_CASTEiJ_G0019237
protein coding gene Chr12:79934762-79936592 (+)
CBA/J MGP_CBAJ_G0019659
protein coding gene Chr12:91365669-91367488 (+)
DBA/2J MGP_DBA2J_G0019774
protein coding gene Chr12:81788008-81789827 (+)
FVB/NJ MGP_FVBNJ_G0019760
protein coding gene Chr12:80749422-80751241 (+)
LP/J MGP_LPJ_G0019846
protein coding gene Chr12:85387227-85389046 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019799
protein coding gene Chr12:94253355-94255174 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0020367
protein coding gene Chr12:84101496-84103315 (+)
PWK/PhJ MGP_PWKPhJ_G0019001
protein coding gene Chr12:76278182-76280014 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018796
protein coding gene Chr12:78572377-78574216 (+)
WSB/EiJ MGP_WSBEiJ_G0019289
protein coding gene Chr12:84813331-84815150 (+)



Homology
more
  • Human Ortholog
    ISCA2, iron-sulfur cluster assembly 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ISCA2, iron-sulfur cluster assembly 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    c14_5557, HBLD1, ISA2, MMDS4
  • Links
    NCBI Gene ID: 122961
    neXtProt AC: NX_Q86U28
    UniProt: Q86U28

  • Chr Location
    14q24.3; chr14:74493720-74495568 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 14260
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: ISCA2
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with human ISCA2 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotype references
  • All Mutations and Alleles
    7
  • Chemically induced (other)
    1
  • Gene trapped
    4
  • Targeted
    2
  • Genomic Mutations
    1 involving Isca2
  • Find Mice (IMSR)
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000021241 Ensembl Gene Model | MGI Sequence Detail 1838 C57BL/6J ±  kb
transcript ENSMUST00000021667 Ensembl | MGI Sequence Detail 883 Not Applicable  
polypeptide ENSMUSP00000021667 Ensembl | MGI Sequence Detail 154 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 45
    Genomic 1
    cDNA 44

    Microarray probesets 3
Other
Accession IDs
less
MGI:1924380
References
more
  • Summaries
    All 30
    Gene Ontology 4
    Phenotypes 6
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:250557 Beilschmidt LK, et al., ISCA1 is essential for mitochondrial Fe4S4 biogenesis in vivo. Nat Commun. 2017 May 11;8:15124

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
10/08/2019
MGI 6.14
The Jackson Laboratory