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Prss46
Gene Detail
Symbol

Name
ID
Prss46
protease, serine 46
MGI:1921556
Synonyms
1700112C13Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 9
60.79 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr9:110844506-110856522 bp, + strand
From VEGA annotation of GRCm38

  12017 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:77706  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog

HCOP human homology predictions: PRSS46
Protein SuperFamily: trypsin
Gene Tree: Prss46

Human
homologs
PRSS46, protease, serine, 46
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 100287362
neXtProt AC: NX_E5RG02

Human Synonyms: TESSP6

Human Chr (Location): chr3:46719583-46736431 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(21) : Gene trapped(18) Spontaneous(1) Targeted(2)
Genomic Mutations involving Prss46 (1)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Prss46 interacts with 50 markers (Mir19b-1, Mir19b-2, Mir22, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (7 annotations)
Process proteolysis
Component integral component of membrane, membrane
Function hydrolase activity, peptidase activity, ...
External Resources: FuncBase
Expression
cDNA source data(4)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(4) cDNA(4)
Microarray probesets(2)
Other database
links
VEGA Gene Model OTTMUSG00000031766 (Evidence)
Ensembl Gene Model ENSMUSG00000049719 (Evidence)
Entrez Gene 74306 (Evidence)
UniGene 87419
DFCI TC1587607
DoTS DT.101162778, DT.60102287
NIA Mouse Gene Index U011074
EC 3.4.21.-
Consensus CDS Project CCDS23576.2
International Mouse Phenotyping Consortium Status Prss46
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000031766 VEGA Gene Model | MGI Sequence Detail 12017 C57BL/6J ±  kb
transcript OTTMUST00000078699 VEGA | MGI Sequence Detail 1257 Not Applicable 
polypeptide OTTMUSP00000041886 VEGA | MGI Sequence Detail 314 Not Applicable 

For the selected sequences
All sequences(21) RefSeq(2) UniProt(2)
Polymorphisms
SNPs within 2kb(61 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001314 Peptidase S1A, chymotrypsin-type
InterPro IPR009003 Peptidase S1, PA clan
InterPro IPR018114 Peptidase S1, trypsin family, active site
InterPro IPR001254 Serine proteases, trypsin domain
Protein Ontology PR:000035339 serine protease 46
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(28)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory