Mtmr3
Gene Detail

Symbol Name ID

Mtmr3 myotubularin related protein 3 MGI:1921552

Synonyms

1700092A20Rik, FYVE-DSP1, mKIAA0371, ZFYVE10

Feature Type

protein coding gene

Genetic Map

Chromosome 11

2.94 cM, cytoband A1
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr11:4480875-4594863 bp, - strand From VEGA annotation of GRCm38   113989 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Mammalian homology

human; rat; cattle; chimpanzee; dog, domestic    (Mammalian Orthology)
Comparative Map (Mouse/Human Mtmr3 ± 2 cM)

Gene Tree: Mtmr3

Human ortholog

MTMR3 myotubularin related protein 3 NCBI Gene ID 8897
Human Synonyms: FYVE-DSP1, ZFYVE10
Human Chr22:30279158-30426857 bp, + strand Reference GRCh37.p2 Primary Assembly

Alleles and phenotypes

All alleles(21) : Targeted(2) Gene trapped(19)
 

Homozygous mutation of this gene results in increased serum alkaline phosphatase level and, in males, impaired glucose tolerance.

 

Gene Ontology (GO) classifications

All GO classifications: (14 annotations)

Process	dephosphorylation, peptidyl-tyrosine dephosphorylation, ...
Component	cytoplasm, membrane
Function	hydrolase activity, metal ion binding, ...

External Resources: FuncBase

Expression

Literature Summary: (3 records)
Data Summary: Results (169)    Tissues (100)    Images (36)
Theiler Stages: 22, 23, 26, 28

Assay Type	Results
RNA in situ	156
RT-PCR	13

cDNA source data(160)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(161) cDNA(160) Primer pair(1)
Microarray probesets(7)

Other database links

VEGA Gene Model	OTTMUSG00000005070 (Evidence)
Ensembl Gene Model	ENSMUSG00000034354 (Evidence)
Entrez Gene	74302 (Evidence)
UniGene	425669
DFCI	TC1577237, TC1607109, TC1616390, TC1631670
DoTS	DT.110505405, DT.491749, DT.91386146, DT.97384092
NIA Mouse Gene Index	U032447
EC	3.1.3.48
Consensus CDS Project	CCDS48744.1
International Mouse Knockout Project Status	Mtmr3

Sequences

Length	Strain/Species
genomic	OTTMUSG00000005070	VEGA Gene Model | MGI Sequence Detail	113989	C57BL/6J
transcript	OTTMUST00000011299	VEGA | MGI Sequence Detail	5466	Not Applicable
polypeptide	OTTMUSP00000005266	VEGA | MGI Sequence Detail	1195	Not Applicable

All sequences(64) RefSeq(2) UniProt(7)

Polymorphisms

SNPs(275 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR017906	Myotubularin phosphatase domain
InterPro	IPR010569	Myotubularin-related
InterPro	IPR016130	Protein-tyrosine phosphatase, active site
InterPro	IPR011011	Zinc finger, FYVE/PHD-type
InterPro	IPR017455	Zinc finger, FYVE-related
InterPro	IPR000306	Zinc finger, FYVE-type
InterPro	IPR013083	Zinc finger, RING/FYVE/PHD-type
Protein Ontology	PR:000010737	myotubularin-related protein 3

References

(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
All references(41)

Other accession IDs

MGI:2144089, MGI:2144577