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Mtmr3
Gene Detail
Symbol

Name
ID
Mtmr3
myotubularin related protein 3
MGI:1921552
Synonyms
1700092A20Rik, FYVE-DSP1, mKIAA0371, ZFYVE10
Feature Type
protein coding gene
Genetic Map
Chromosome 11
2.94 cM, cytoband A1
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr11:4480875-4594863 bp, - strand
From VEGA annotation of GRCm38

  113989 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:23662  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: MTMR3
Gene Tree: Mtmr3

Human
homologs
MTMR3, myotubularin related protein 3
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 8897
neXtProt AC: NX_Q13615

Human Synonyms: FYVE-DSP1, ZFYVE10

Human Chr (Location): 22q12.2; chr22:29883165-30030868 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(22) : Gene trapped(19) Targeted(3)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygous mutation of this gene results in increased serum alkaline phosphatase level and, in males, impaired glucose tolerance.
 
Interactions
Mtmr3 interacts with 317 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (18 annotations)
Process dephosphorylation, lipid metabolic process, ...
Component cytoplasm, extrinsic component of membrane, ...
Function hydrolase activity, metal ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (169)    Tissues (101)    Images (36)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 156
RT-PCR 13
cDNA source data(160)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase mtmr3    NEW 
Molecular
reagents
All nucleic(161) cDNA(160) Primer pair(1)
Microarray probesets(7)
Other database
links
VEGA Gene Model OTTMUSG00000005070 (Evidence)
Ensembl Gene Model ENSMUSG00000034354 (Evidence)
Entrez Gene 74302 (Evidence)
UniGene 425669
DFCI TC1631670, TC1616390, TC1607109, TC1577237
DoTS DT.110505405, DT.97384092, DT.91386146, DT.491749
NIA Mouse Gene Index U032447
EC 3.1.3.95, 3.1.3.64, 3.1.3.48
Consensus CDS Project CCDS48744.1
International Mouse Phenotyping Consortium Status Mtmr3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005070 VEGA Gene Model | MGI Sequence Detail 113989 C57BL/6J ±  kb
transcript OTTMUST00000011299 VEGA | MGI Sequence Detail 5466 Not Applicable 
polypeptide OTTMUSP00000005266 VEGA | MGI Sequence Detail 1195 Not Applicable 

For the selected sequences
All sequences(76) RefSeq(10) UniProt(9)
Polymorphisms
SNPs within 2kb(319 from dbSNP Build 137)    SNPs within 2kb including multiple locations(321)
Protein-related
information
ResourceIDDescription
InterPro IPR010569 Myotubularin-related
InterPro IPR016130 Protein-tyrosine phosphatase, active site
InterPro IPR011011 Zinc finger, FYVE/PHD-type
InterPro IPR017455 Zinc finger, FYVE-related
InterPro IPR000306 Zinc finger, FYVE-type
InterPro IPR013083 Zinc finger, RING/FYVE/PHD-type
Protein Ontology PR:000010737 myotubularin-related protein 3
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
All references(41)
Other
accession IDs
MGI:2144089, MGI:2144577

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory