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Kcmf1 Gene Detail
Summary
  • Symbol
    Kcmf1
  • Name
    potassium channel modulatory factor 1
  • Synonyms
    1700094M07Rik, clone DEBT-91, Pmcf
  • Feature Type
    protein coding gene
  • IDs
    MGI:1921537
    NCBI Gene: 74287
  • Alliance
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:72841114-72899979 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 32.30 cM, cytoband C3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    259 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1921537
protein coding gene Chr6:72841114-72899979 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030884
protein coding gene Chr6:73438391-73501357 (-)
A/J MGP_AJ_G0030854
protein coding gene Chr6:70576186-70635163 (-)
AKR/J MGP_AKRJ_G0030783
protein coding gene Chr6:72670797-72728801 (-)
BALB/cJ MGP_BALBcJ_G0030865
protein coding gene Chr6:70601794-70659241 (-)
C3H/HeJ MGP_C3HHeJ_G0030847
protein coding gene Chr6:111527502-111590017 (+)
C57BL/6NJ MGP_C57BL6NJ_G0031323
protein coding gene Chr6:75350400-75418384 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028512
protein coding gene Chr6:69712668-69769826 (-)
CAST/EiJ MGP_CASTEiJ_G0029973
protein coding gene Chr6:72529462-72591333 (-)
CBA/J MGP_CBAJ_G0030552
protein coding gene Chr6:78434249-78504506 (-)
DBA/2J MGP_DBA2J_G0030704
protein coding gene Chr6:69962373-70019083 (-)
FVB/NJ MGP_FVBNJ_G0030657
protein coding gene Chr6:69357606-69415175 (-)
LP/J MGP_LPJ_G0030783
protein coding gene Chr6:73340377-73406224 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030692
protein coding gene Chr6:81795568-81861965 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031349
protein coding gene Chr6:72487688-72550031 (-)
PWK/PhJ MGP_PWKPhJ_G0029689
protein coding gene Chr6:68888208-68948924 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029517
protein coding gene Chr6:71229074-71291626 (-)
WSB/EiJ MGP_WSBEiJ_G0030055
protein coding gene Chr6:72859055-72922120 (-)



Homology
more
  • Human Ortholog
    KCMF1, potassium channel modulatory factor 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    KCMF1, potassium channel modulatory factor 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    DEBT91, FIGC, PCMF, ZZZ1
  • Links
    NCBI Gene ID: 56888
    neXtProt AC: NX_Q9P0J7
    UniProt: Q9P0J7

  • Chr Location
    2p11.2; chr2:84971108-85059472 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    4 phenotypes from multigenic genotypes
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trapped allele exhibit some perinatal and postnatal lethality but mice that survive to adulthood exhibit normal lethality.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 74287 NCBI Gene Model | MGI Sequence Detail 58866 C57BL/6J ±  kb
transcript NM_019715 RefSeq | MGI Sequence Detail 3251 C57BL/6  
polypeptide Q80UY2 UniProt | EBI | MGI Sequence Detail 381 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 109
    cDNA 107
    Primer pair 2

    Microarray probesets 5
References
more
  • Summaries
    All 43
    Developmental Gene Expression 4
    Gene Ontology 4
    Phenotypes 14
  • Earliest
    J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-Le-Grand). 1999 Jul;45(5):737-50
  • Latest
    J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory