Chic2 MGI Mouse Gene Detail - MGI:1921527 - cysteine-rich hydrophobic domain 2

Symbol

Chic2
Name

cysteine-rich hydrophobic domain 2
Synonyms

1700081B18Rik, 4930502K01Rik, BTL

Feature Type

protein coding gene
IDs

MGI:1921527
NCBI Gene: 74277
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr5:75165665-75205302 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 5, 39.54 cM, cytoband D
Mapping Data

2 experiments

SNPs within 2kb

714 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1921527	protein coding gene	Chr5:75158649-75205435 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0029635	protein coding gene	Chr5:75107890-75155501 (-)
A/J	MGP_AJ_G0029603	protein coding gene	Chr5:72253236-72300584 (-)
AKR/J	MGP_AKRJ_G0029551	protein coding gene	Chr5:74607990-74654974 (-)
BALB/cJ	MGP_BALBcJ_G0029612	protein coding gene	Chr5:72963229-73009876 (-)
C3H/HeJ	MGP_C3HHeJ_G0029335	protein coding gene	Chr5:74989635-75040653 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0030066	protein coding gene	Chr5:78135861-78183691 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0027306	protein coding gene	Chr5:67927049-67975407 (-)
CAST/EiJ	MGP_CASTEiJ_G0028743	protein coding gene	Chr5:74104814-74155492 (-)
CBA/J	MGP_CBAJ_G0029304	protein coding gene	Chr5:80717641-80771622 (-)
DBA/2J	MGP_DBA2J_G0029449	protein coding gene	Chr5:72332788-72381427 (-)
FVB/NJ	MGP_FVBNJ_G0029410	protein coding gene	Chr5:71484581-71533515 (-)
LP/J	MGP_LPJ_G0029535	protein coding gene	Chr5:75532373-75582570 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0029437	protein coding gene	Chr5:83934075-83985494 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0030099	protein coding gene	Chr5:74142575-74189656 (-)
PWK/PhJ	MGP_PWKPhJ_G0028466	protein coding gene	Chr5:71327905-71372620 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0028301	protein coding gene	Chr5:73498523-73550033 (-)
WSB/EiJ	MGP_WSBEiJ_G0028823	protein coding gene	Chr5:74432359-74482142 (-)

Human Ortholog

CHIC2, cysteine rich hydrophobic domain 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CHIC2, cysteine rich hydrophobic domain 2
Synonyms

BTL
Links

HGNC:1935

NCBI Gene ID: 26511

UniProt: Q9UKJ5
Chr Location

4q12; chr4:53994803-54091879 (-) GRCh38

MGI Vertebrate Homology

Chic2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: CHIC2
Gene Tree

Chic2

Diseases

1 with human CHIC2 associations

				Human Disease	Mouse Models
				acute myeloid leukemia IDs acute myeloid leukemia DOID:9119 DOID:9118 DOID:9171 ICD10CM:C92.0 ICD9CM:205.0 KEGG:05221 MESH:D015470 NCI:C3171 OMIM:601626 UMLS_CUI:C0023467

Click on a disease name to see all genes associated with that disease.

References

1 with disease annotations

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Phenotype Summary

8 phenotypes from 1 allele in 1 genetic background
385 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

25
Chemically induced (other)

2
Endonuclease-mediated

2
Gene trapped

13
Radiation induced

1
Spontaneous

3
Targeted

4
Genomic Mutations

6 involving Chic2
Incidental Mutations

APF
Find Mice (IMSR)

15 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

13
GO References

6

Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

763
Tissues

41
cDNA Data

78
Literature Summary

1

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase chic2

ZFIN chic2

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All Sequences

38
RefSeq

2
UniProt

1
CCDS

CCDS19349.1

Ensembl

ENSMUSG00000029229 (Evidence)
NCBI Gene

74277

			Length	Strain/Species	Flank
genomic	74277	NCBI Gene Model \| MGI Sequence Detail	39638	C57BL/6J	± kb
transcript	NM_028850	RefSeq \| MGI Sequence Detail	2550	C57BL/6
polypeptide	Q9D9G3	UniProt \| EBI \| MGI Sequence Detail	165	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000031951 cysteine-rich hydrophobic domain-containing protein 2

(term hierarchy)
InterPro Domains

IPR039735 Cysteine-rich hydrophobic domain-containing protein 1/2

IPR019383 Golgin subfamily A member 7/ERF4

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All nucleic 78

cDNA 78

Microarray probesets 5

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MGI:1922202

Summaries

All 412

Developmental Gene Expression 1

Diseases 1

Gene Ontology 6

Phenotypes 385
Earliest

J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
Latest

J:373384 Mamuladze T, et al., Mast cells regulate the brain-dura interface and CSF dynamics. Cell. 2025 Oct 2;188(20):5487-5498.e16

TSS for Chic2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr51401	Chr5:75205358-75205369 (-)	-62 bp
Tssr51400	Chr5:75205334-75205356 (-)	-43 bp
Tssr51399	Chr5:75205223-75205323 (-)	29 bp
Tssr51398	Chr5:75205124-75205161 (-)	159 bp
Tssr51397	Chr5:75205074-75205085 (-)	222 bp
Tssr51396	Chr5:75203918-75203924 (-)	1,381 bp
Tssr51395	Chr5:75203844-75203862 (-)	1,449 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/30/2025 MGI 6.24