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Iqcf1 Gene Detail
Summary
  • Symbol
    Iqcf1
  • Name
    IQ motif containing F1
  • Synonyms
    1700055J15Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1921517
    NCBI Gene: 74267
Location & Maps
more
  • Sequence Map
    Chr9:106499967-106502249 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      2283 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 57.65 cM, cytoband F1
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    IQCF1, IQ motif containing F1
  • Vertebrate Orthologs
    6
  • Human Ortholog
    IQCF1, IQ motif containing F1
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 132141
    neXtProt AC: NX_Q8N6M8

  • Chr Location
    3p21.2; chr3:51894876-51903370 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    2 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    3
  • Endonuclease-mediated
    1
  • Targeted
    2
Mice homozygous for a knock-out allele exhibit reduced male fertility associated with decreased sperm motility and impaired induced acrosome reaction.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000049449 VEGA Gene Model | MGI Sequence Detail 2283 C57BL/6J ±  kb
transcript OTTMUST00000126063 VEGA | MGI Sequence Detail 608 Not Applicable  
polypeptide OTTMUSP00000068219 VEGA | MGI Sequence Detail 182 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    62 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 25
    cDNA 25

    Microarray probesets 2
References
more
  • Summaries
    All 20
    Gene Ontology 3
    Phenotypes 2
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:228595 Fang P, et al., A novel acrosomal protein, IQCF1, involved in sperm capacitation and the acrosome reaction. Andrology. 2015 Mar;3(2):332-44

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory