About   Help   FAQ
Ctbs
Gene Detail
Symbol

Name
ID
Ctbs
chitobiase, di-N-acetyl-
MGI:1921495
Synonyms
2210401K11Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 3
71.26 cM, cytoband H3
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr3:146450470-146465849 bp, + strand
From VEGA annotation of GRCm38

  15380 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3231  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: CTBS
Gene Tree: Ctbs

Human
homologs
CTBS, chitobiase, di-N-acetyl-
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 1486
neXtProt AC: NX_Q01459

Human Synonyms: CTB

Human Chr (Location): 1p22; chr1:84553121-84574480 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a knock-out allele exhibit accumulation of oligosaccharides.
 
Interactions
Ctbs interacts with 262 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (29 annotations)
Process carbohydrate metabolic process, chitin catabolic process, ...
Component extracellular exosome, extracellular region, ...
Function amylase activity, beta-6-sulfate-N-acetylglucosaminidase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (111)    Tissues (8)    Images (21)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 111
cDNA source data(17)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase ctbs    NEW 
Molecular
reagents
All nucleic(17) cDNA(17)
Microarray probesets(6)
Other database
links
VEGA Gene Model OTTMUSG00000022279 (Evidence)
Ensembl Gene Model ENSMUSG00000028189 (Evidence)
Entrez Gene 74245 (Evidence)
UniGene 45396
DFCI TC1583318, TC1610769
DoTS DT.94296176, DT.40172479
NIA Mouse Gene Index U003961
EC 3.2.1.-
Consensus CDS Project CCDS17902.1
International Mouse Phenotyping Consortium Status Ctbs
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022279 VEGA Gene Model | MGI Sequence Detail 15380 C57BL/6J ±  kb
transcript OTTMUST00000053066 VEGA | MGI Sequence Detail 2892 Not Applicable 
polypeptide OTTMUSP00000025213 VEGA | MGI Sequence Detail 366 Not Applicable 

For the selected sequences
All sequences(29) RefSeq(4) UniProt(2)
Polymorphisms
SNPs within 2kb(130 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR011583 Chitinase II
InterPro IPR013781 Glycoside hydrolase, catalytic domain
InterPro IPR001579 Glycoside hydrolase, chitinase active site
InterPro IPR001223 Glycoside hydrolase, family 18, catalytic domain
InterPro IPR017853 Glycoside hydrolase, superfamily
Protein Ontology PR:000005996 di-N-acetylchitobiase
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:185162 Persichetti E, et al., Lysosomal di-N-acetylchitobiase-deficient mouse tissues accumulate Man2GlcNAc2 and Man3GlcNAc2. Biochim Biophys Acta. 2012 Jul;1822(7):1137-46
All references(32)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
07/28/2015
MGI 5.22
The Jackson Laboratory