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Ctbs
Gene Detail
Symbol

Name
ID
Ctbs
chitobiase, di-N-acetyl-
MGI:1921495
Synonyms
2210401K11Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 3
71.26 cM, cytoband H3
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr3:146450470-146465849 bp, + strand
From VEGA annotation of GRCm38

  15380 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3231  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Ctbs

Human
homologs
Human Homolog CTBS, chitobiase, di-N-acetyl-
NCBI Gene ID 1486
neXtProt AC  NX_Q01459
Human Synonyms  CTB
Human Chr (Location)  1p22; chr1:84553121-84574480 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit accumulation of oligosaccharides.
 
Interactions
Ctbs interacts with 262 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (29 annotations)
Process carbohydrate metabolic process, chitin catabolic process, ...
Component extracellular region, extracellular space, ...
Function amylase activity, beta-6-sulfate-N-acetylglucosaminidase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (111)    Tissues (8)    Images (21)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 111
cDNA source data(17)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(17) cDNA(17)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000022279 (Evidence)
Ensembl Gene ModelENSMUSG00000028189 (Evidence)
Entrez Gene74245 (Evidence)
UniGene45396
DFCITC1610769, TC1583318
DoTSDT.40172479, DT.94296176
NIA Mouse Gene IndexU003961
EC3.2.1.-
Consensus CDS ProjectCCDS17902.1
International Mouse Knockout Project StatusCtbs
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022279 VEGA Gene Model | MGI Sequence Detail 15380 C57BL/6J ±  kb
transcript OTTMUST00000053066 VEGA | MGI Sequence Detail 2892 Not Applicable 
polypeptide OTTMUSP00000025213 VEGA | MGI Sequence Detail 366 Not Applicable 

For the selected sequences
All sequences(30) RefSeq(4) UniProt(3)
Polymorphisms
SNPs within 2kb(130 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR011583 Chitinase II
InterPro IPR013781 Glycoside hydrolase, catalytic domain
InterPro IPR001579 Glycoside hydrolase, chitinase active site
InterPro IPR001223 Glycoside hydrolase, family 18, catalytic domain
InterPro IPR017853 Glycoside hydrolase, superfamily
Protein Ontology PR:000005996 di-N-acetylchitobiase
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:185162 Persichetti E, et al., Lysosomal di-N-acetylchitobiase-deficient mouse tissues accumulate Man2GlcNAc2 and Man3GlcNAc2. Biochim Biophys Acta. 2012 Jul;1822(7):1137-46
All references(33)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory