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Acsl3
Gene Detail
Symbol

Name
ID
Acsl3
acyl-CoA synthetase long-chain family member 3
MGI:1921455
Synonyms
2610510B12Rik, C85929, Facl3
Feature Type
protein coding gene
Genetic Map
Chromosome 1
40.84 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr1:78657825-78707743 bp, + strand
From VEGA annotation of GRCm38

  49919 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3278  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

HCOP human homology predictions: ACSL3
Gene Tree: Acsl3

Human
homologs
ACSL3, acyl-CoA synthetase long-chain family member 3
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 2181
neXtProt AC: NX_O95573

Human Synonyms: ACS3, FACL3, PRO2194

Human Chr (Location): 2q34-q35; chr2:222860984-222943401 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(11) : Gene trapped(9) Targeted(2)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygous mice exhibit decreased blood percentages of CD4 T cells and B cells, and a decreased IgG1 response to ovalbumin. Male mutant mice exhibit growth retardation, reduced size and reduced total tissue and lean body mass.
 
Interactions
Acsl3 interacts with 224 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (29 annotations)
Process fatty acid biosynthetic process, fatty acid metabolic process, ...
Component endoplasmic reticulum, Golgi apparatus, ...
Function ATP binding, catalytic activity, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (107)    Tissues (98)    Images (13)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 95
RT-PCR 12
cDNA source data(10)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase acsl4 ; ZFIN acsl3a, acsl3b    NEW 
Molecular
reagents
All nucleic(11) cDNA(10) Primer pair(1)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000033118 (Evidence)
Ensembl Gene Model ENSMUSG00000032883 (Evidence)
Entrez Gene 74205 (Evidence)
DFCI TC1575095, TC1606937, TC1759157
EC 6.2.1.3
Consensus CDS Project CCDS15087.1, CCDS48295.1
International Mouse Phenotyping Consortium Status Acsl3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000033118 VEGA Gene Model | MGI Sequence Detail 49919 C57BL/6J ±  kb
transcript OTTMUST00000082784 VEGA | MGI Sequence Detail 3950 Not Applicable 
polypeptide OTTMUSP00000044415 VEGA | MGI Sequence Detail 720 Not Applicable 

For the selected sequences
All sequences(54) RefSeq(6) UniProt(3)
Polymorphisms
SNPs within 2kb(265 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR020845 AMP-binding, conserved site
InterPro IPR000873 AMP-dependent synthetase/ligase
Protein Ontology PR:000003660 long-chain-fatty-acid--CoA ligase 3
References
(Earliest) J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
(Latest) J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
All references(36)
Other
accession IDs
MGI:2138711

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory