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Eif4enif1 Gene Detail
Summary
  • Symbol
    Eif4enif1
  • Name
    eukaryotic translation initiation factor 4E nuclear import factor 1
  • Synonyms
    2610509L04Rik, A930019J01Rik, Clast4, D11Ertd166e
  • Feature Type
    protein coding gene
  • IDs
    MGI:1921453
    NCBI Gene: 74203
  • Alliance
    genome feature page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:3152392-3194588 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 2.24 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    805 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1921453
 protein coding gene Chr11:3152344-3194588 (+)
129S1/SvImJ ENSMUSG00200028834
 protein coding gene Chr11:106528-147576 (+)
A/J ENSMUSG00195022469
 protein coding gene Chr11:13893-54927 (+)
AKR/J ENSMUSG00220008232
 protein coding gene Chr11:27070-68038 (+)
BALB/cJ ENSMUSG00180021907
 protein coding gene Chr11:36918-77883 (+)
C3H/HeJ ENSMUSG00175009156
 protein coding gene Chr11:26742-67709 (+)
C57BL/6NJ ENSMUSG00215027136
 protein coding gene Chr11:37052-78015 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0016005
 protein coding gene Chr11:30585-74899 (+)
CAST/EiJ ENSTCUG00005036214
 protein coding gene Chr11:121411-162822 (+)
CBA/J ENSMUSG00210018146
 protein coding gene Chr11:26490-67451 (+)
DBA/2J ENSMUSG00185016162
 protein coding gene Chr11:124094-165061 (+)
FVB/NJ ENSMUSG00205016211
 protein coding gene Chr11:6910-38334 (+)
JF1/MsJ ENSUMUG00000040378
 protein coding gene Chr11:269125-310409 (+)
LP/J ENSMUSG00230031196
 protein coding gene Chr11:1189778-1230817 (+)
NOD/ShiLtJ ENSMUSG00190027650
 protein coding gene Chr11:13817-54846 (+)
NZO/HlLtJ ENSMUSG00225025211
 protein coding gene Chr11:3246752-3287785 (+)
PWK/PhJ ENSLUMG00010019016
 protein coding gene Chr11:14352-55564 (+)
SPRET/EiJ ENSMSPG00010008245
 protein coding gene Chr11:97696-140219 (+)
WSB/EiJ ENSIUOG00005007017
 protein coding gene Chr11:27710-68727 (+)



Homology
more
  • Human Ortholog
    EIF4ENIF1, eukaryotic translation initiation factor 4E nuclear import factor 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    EIF4ENIF1, eukaryotic translation initiation factor 4E nuclear import factor 1
  • Synonyms
    4E-T, Clast4
  • Links
    NCBI Gene ID: 56478
    UniProt: Q9NRA8

  • Chr Location
    22q12.2; chr22:31436963-31497047 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 1 allele in 1 genetic background
    1 phenotype from multigenic genotypes
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    56
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    691
  • Tissues
    26
  • cDNA Data
    136
  • Literature Summary
    8
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000020454 Ensembl Gene Model | MGI Sequence Detail 42197 C57BL/6J ±  kb
    transcript ENSMUST00000179770 Ensembl | MGI Sequence Detail 3676 Not Applicable  
    polypeptide ENSMUSP00000136768 Ensembl | MGI Sequence Detail 983 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      7 Sequences
    • Protein Ontology
      PR:000006997 eukaryotic translation initiation factor 4E transporter
      (term hierarchy)
    • InterPro Domains
      IPR018862 Eukaryotic translation initiation factor 4E binding protein
    • GlyGen
      Q9EST3 12 sites, 2 N-linked glycans (2 sites), 1 O-linked glycan (9 sites)
    Molecular
    Reagents
    less
    • All nucleic 141
      cDNA 136
      Primer pair 5
      Antibodies 5

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1098834, MGI:1925202, MGI:2144007, MGI:2144407
    References
    more
    • Summaries
      All 59
      Developmental Gene Expression 8
      Gene Ontology 11
      Phenotypes 17
    • Earliest
      J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/15/2026
    MGI 6.29     		The Jackson Laboratory