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Fblim1 Gene Detail
Summary
  • Symbol
    Fblim1
  • Name
    filamin binding LIM protein 1
  • Synonyms
    2410043F08Rik, Fblp1, migfilin, migfilin(s)
  • Feature Type
    protein coding gene
  • IDs
    MGI:1921452
    NCBI Gene: 74202
  • Gene Overview
    MyGene.info: FBLIM1
  • Alliance
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:141576062-141606052 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 74.64 cM, cytoband E1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    300 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1921452
protein coding gene Chr4:141576062-141606096 (-)
129S1/SvImJ MGP_129S1SvImJ_G0029050
protein coding gene Chr4:144655615-144686396 (-)
A/J MGP_AJ_G0029010
protein coding gene Chr4:138350113-138379746 (-)
AKR/J MGP_AKRJ_G0028962
protein coding gene Chr4:142361293-142395281 (-)
BALB/cJ MGP_BALBcJ_G0029034
protein coding gene Chr4:139044322-139074525 (-)
C3H/HeJ MGP_C3HHeJ_G0028748
protein coding gene Chr4:142729154-142763289 (-)
C57BL/6NJ MGP_C57BL6NJ_G0029475
protein coding gene Chr4:149682035-149724225 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026746
protein coding gene Chr4:131259021-131292845 (-)
CAST/EiJ MGP_CASTEiJ_G0028180
protein coding gene Chr4:140997227-141037882 (-)
CBA/J MGP_CBAJ_G0028712
protein coding gene Chr4:154077248-154119260 (-)
DBA/2J MGP_DBA2J_G0028862
protein coding gene Chr4:138747910-138777989 (-)
FVB/NJ MGP_FVBNJ_G0028829
protein coding gene Chr4:137866807-137896789 (-)
LP/J MGP_LPJ_G0028961
protein coding gene Chr4:144674742-144707486 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0028855
protein coding gene Chr4:157844605-157878115 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0029513
protein coding gene Chr4:142883583-142915563 (-)
PWK/PhJ MGP_PWKPhJ_G0027901
protein coding gene Chr4:135636577-135668232 (-)
SPRET/EiJ MGP_SPRETEiJ_G0027725
protein coding gene Chr4:138694270-138727257 (-)
WSB/EiJ MGP_WSBEiJ_G0028258
protein coding gene Chr4:143166343-143196258 (-)



Homology
more
  • Human Ortholog
    FBLIM1, filamin binding LIM protein 1
  • Vertebrate Orthologs
    8
  • Human Ortholog
    FBLIM1, filamin binding LIM protein 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CAL, FBLP1, FBLP-1
  • Links
    NCBI Gene ID: 54751
    neXtProt AC: NX_Q8WUP2
    UniProt: Q8WUP2

  • Chr Location
    1p36.21; chr1:15756171-15786590 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    12 phenotypes from 2 alleles in 2 genetic backgrounds
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for one knock-out allele exhibit severe osteopenia with decreased osteoblasts and increased osteoclasts.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 74202 NCBI Gene Model | MGI Sequence Detail 29991 C57BL/6J ±  kb
    transcript NM_133754 RefSeq | MGI Sequence Detail 3109 C57BL/6  
    polypeptide Q71FD7 UniProt | EBI | MGI Sequence Detail 375 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 95
      cDNA 93
      Primer pair 2

      Microarray probesets 4
    References
    more
    • Summaries
      All 51
      Developmental Gene Expression 9
      Gene Ontology 2
      Phenotypes 17
    • Earliest
      J:1146 Skarnes WC, et al., A gene trap approach in mouse embryonic stem cells: the lacZ reported is activated by splicing, reflects endogenous gene expression, and is mutagenic in mice. Genes Dev. 1992 Jun;6(6):903-18
    • Latest
      J:250639 Haubner BJ, et al., In vivo cardiac role of migfilin during experimental pressure overload. Cardiovasc Res. 2015 Jun 1;106(3):398-407

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    Funding Information
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory