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Fblim1
Gene Detail
 Symbol
Name
ID
Fblim1
filamin binding LIM protein 1
MGI:1921452
Synonyms 2410043F08Rik, Fblp1, migfilin, migfilin(s)
Feature Type protein coding gene
Genetic Map
Chromosome 4
74.64 cM, cytoband E1
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr4:141576062-141606096 bp, - strand
From VEGA annotation of GRCm38

  30035 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:56774  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Gene Tree: Fblim1

Human
homologs
Human Homolog FBLIM1, filamin binding LIM protein 1
NCBI Gene ID 54751
neXtProt AC  NX_Q8WUP2
Human Synonyms  CAL, FBLP1, FBLP-1
Human Chr (Location)  1p36.21; chr1:15756340-15786594 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(115) : Gene trapped(112) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for one knock-out allele exhibit severe osteopenia with decreased osteoblasts and increased osteoclasts.
 
Interactions
Fblim1 interacts with 215 markers (Mir15a, Mir15b, Mir16-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (12 annotations)
Process cell adhesion, regulation of cell shape, ...
Component cell junction, cytoplasm, ...
Function filamin binding, metal ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (9 records)
Data Summary: Results (198)    Tissues (81)    Images (16)
Theiler Stages: 2, 3, 4, 5, 11, 13, 15, 17, 19, 21, 23, 27, 28
Assay TypeResults
RNA in situ 154
RT-PCR 44
cDNA source data(92)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(94) cDNA(92) Primer pair(2)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000010344 (Evidence)
Ensembl Gene ModelENSMUSG00000006219 (Evidence)
Entrez Gene74202 (Evidence)
UniGene490327
DFCITC1578466, TC1616097, TC1617388, TC1697667
DoTSDT.101284551, DT.101328406, DT.101397955, DT.530678, DT.97375153, DT.99856582
NIA Mouse Gene IndexU025726
Consensus CDS ProjectCCDS18876.1
International Mouse Knockout Project StatusFblim1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000010344 VEGA Gene Model | MGI Sequence Detail 30035 C57BL/6J ±  kb
transcript OTTMUST00000024098 VEGA | MGI Sequence Detail 3101 Not Applicable 
polypeptide OTTMUSP00000011063 VEGA | MGI Sequence Detail 375 Not Applicable 

For the selected sequences
All sequences(110) RefSeq(12) UniProt(10)
Polymorphisms SNPs within 2kb(301 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001781 Zinc finger, LIM-type
Protein Ontology PR:000007357 filamin-binding LIM protein 1
References (Earliest) J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-le-grand). 1999 Jul;45(5):737-50
(Latest) J:207237 Brahme NN, et al., Kindlin binds migfilin tandem LIM domains and regulates migfilin focal adhesion localization and recruitment dynamics. J Biol Chem. 2013 Dec 6;288(49):35604-16
All references(48)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory