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Dtx2 Gene Detail
Summary
  • Symbol
    Dtx2
  • Name
    deltex 2, E3 ubiquitin ligase
  • Synonyms
    2610524D08Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1921448
    NCBI Gene: 74198
  • Gene Overview
    MyGene.info: DTX2
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:135994800-136032872 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 75.64 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    203 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1921448
protein coding gene Chr5:135994800-136032881 (.)
129S1/SvImJ MGP_129S1SvImJ_G0030196
protein coding gene Chr5:140604895-140642808 (+)
A/J MGP_AJ_G0030164
protein coding gene Chr5:134556063-134594181 (+)
AKR/J MGP_AKRJ_G0030097
protein coding gene Chr5:138907030-138948826 (+)
BALB/cJ MGP_BALBcJ_G0030174
protein coding gene Chr5:135912908-135951537 (+)
C3H/HeJ MGP_C3HHeJ_G0029890
protein coding gene Chr5:139514771-139555981 (+)
C57BL/6NJ MGP_C57BL6NJ_G0030627
protein coding gene Chr5:145831850-145875191 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027848
protein coding gene Chr5:128844711-128882341 (+)
CAST/EiJ MGP_CASTEiJ_G0029300
protein coding gene Chr5:138914035-138954101 (+)
CBA/J MGP_CBAJ_G0029860
protein coding gene Chr5:151517797-151562824 (+)
DBA/2J MGP_DBA2J_G0030011
protein coding gene Chr5:134459152-134497508 (+)
FVB/NJ MGP_FVBNJ_G0029966
protein coding gene Chr5:133608435-133647373 (+)
LP/J MGP_LPJ_G0030100
protein coding gene Chr5:141030238-141071221 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0029998
protein coding gene Chr5:154511299-154553233 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0030667
protein coding gene Chr5:138706510-138746163 (+)
PWK/PhJ MGP_PWKPhJ_G0029013
protein coding gene Chr5:133516552-133555546 (+)
SPRET/EiJ MGP_SPRETEiJ_G0028849
protein coding gene Chr5:136259982-136298388 (+)
WSB/EiJ MGP_WSBEiJ_G0029373
protein coding gene Chr5:139440360-139480499 (+)



Homology
more
  • Human Ortholog
    DTX2, deltex E3 ubiquitin ligase 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    DTX2, deltex E3 ubiquitin ligase 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    RNF58
  • Links
    NCBI Gene ID: 113878
    neXtProt AC: NX_Q86UW9
    UniProt: Q86UW9

  • Chr Location
    7q11.23; chr7:76461655-76505995 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 56904
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: DTX2
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    1 phenotype from multigenic genotypes
    7 phenotype references
Mice homozygous for a knock-out allele are viable and overtly normal with no detectable abnormalities in T or B cell development.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000004947 Ensembl Gene Model | MGI Sequence Detail 38073 C57BL/6J ±  kb
transcript ENSMUST00000111142 Ensembl | MGI Sequence Detail 2650 Not Applicable  
polypeptide ENSMUSP00000106772 Ensembl | MGI Sequence Detail 619 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 78
    cDNA 76
    Primer pair 2

    Microarray probesets 4
Other
Accession IDs
less
MGI:2140736, MGI:2141064
References
more
  • Summaries
    All 36
    Developmental Gene Expression 4
    Gene Ontology 5
    Phenotypes 7
  • Earliest
    J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
  • Latest
    J:242144 Luo D, et al., Deltex2 represses MyoD expression and inhibits myogenic differentiation by acting as a negative regulator of Jmjd1c. Proc Natl Acad Sci U S A. 2017 Apr 11;114(15):E3071-E3080

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory