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Elp3 Gene Detail
Summary
  • Symbol
    Elp3
  • Name
    elongator acetyltransferase complex subunit 3
  • Synonyms
    2610507P14Rik, KAT9
  • Feature Type
    protein coding gene
  • IDs
    MGI:1921445
    NCBI Gene: 74195
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:65767898-65830524 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 14, 34.33 cM, cytoband D1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    556 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1921445
protein coding gene Chr14:65767895-65830561 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021481
protein coding gene Chr14:60142288-60206773 (-)
A/J MGP_AJ_G0021440
protein coding gene Chr14:58749688-58812580 (-)
AKR/J MGP_AKRJ_G0021416
protein coding gene Chr14:60788384-60851414 (-)
BALB/cJ MGP_BALBcJ_G0021446
protein coding gene Chr14:58684812-58748091 (-)
C3H/HeJ MGP_C3HHeJ_G0021223
protein coding gene Chr14:60430062-60492659 (-)
C57BL/6NJ MGP_C57BL6NJ_G0021885
protein coding gene Chr14:62918407-62982646 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019425
protein coding gene Chr14:56680736-56743334 (-)
CAST/EiJ MGP_CASTEiJ_G0020740
protein coding gene Chr14:56914168-56979289 (-)
CBA/J MGP_CBAJ_G0021190
protein coding gene Chr14:64821016-64885744 (-)
DBA/2J MGP_DBA2J_G0021313
protein coding gene Chr14:58397294-58460391 (-)
FVB/NJ MGP_FVBNJ_G0021292
protein coding gene Chr14:57798216-57860617 (-)
LP/J MGP_LPJ_G0021388
protein coding gene Chr14:61177840-61241561 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021321
protein coding gene Chr14:63922622-63986794 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0021908
protein coding gene Chr14:59967686-60032581 (-)
PWK/PhJ MGP_PWKPhJ_G0020484
protein coding gene Chr14:55107960-55171676 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020317
protein coding gene Chr14:55939748-56003162 (-)
WSB/EiJ MGP_WSBEiJ_G0020793
protein coding gene Chr14:60274177-60341392 (-)



Homology
more
  • Human Ortholog
    ELP3, elongator acetyltransferase complex subunit 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ELP3, elongator acetyltransferase complex subunit 3
  • Synonyms
    KAT9
  • Links
    NCBI Gene ID: 55140
    neXtProt AC: NX_Q9H9T3
    UniProt: Q9H9T3

  • Chr Location
    8p21.1; chr8:28089673-28191156 (+)  GRCh38

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 2 alleles in 3 genetic backgrounds
    9 phenotypes from multigenic genotypes
    21 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Embryos homozygous for a null gene trap mutation show severe growth retardation and die prior to E12.5.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000022031 Ensembl Gene Model | MGI Sequence Detail 62627 C57BL/6J ±  kb
    transcript ENSMUST00000022609 Ensembl | MGI Sequence Detail 2851 Not Applicable  
    polypeptide ENSMUSP00000022609 Ensembl | MGI Sequence Detail 566 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 11
      cDNA 10
      Primer pair 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 55
      Developmental Gene Expression 8
      Gene Ontology 6
      Phenotypes 21
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:340593 Pereira M, et al., Amyloid pathology reduces ELP3 expression and tRNA modifications leading to impaired proteostasis. Biochim Biophys Acta Mol Basis Dis. 2023 Aug 26;1870(1):166857

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    03/12/2024
    MGI 6.23
    The Jackson Laboratory