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Rnd3 Gene Detail
Summary
  • Symbol
    Rnd3
  • Name
    Rho family GTPase 3
  • Synonyms
    2610017M01Rik, Arhe, Rhoe
  • Feature Type
    protein coding gene
  • IDs
    MGI:1921444
    NCBI Gene: 74194
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:51020451-51039123 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 2, 29.63 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    220 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1921444
protein coding gene Chr2:51020450-51039123 (-)
129S1/SvImJ MGP_129S1SvImJ_G0025727
protein coding gene Chr2:50383849-50402606 (-)
A/J MGP_AJ_G0025703
protein coding gene Chr2:48452716-48471495 (-)
AKR/J MGP_AKRJ_G0025673
protein coding gene Chr2:49849845-49868536 (-)
BALB/cJ MGP_BALBcJ_G0025698
protein coding gene Chr2:48555015-48574151 (-)
C3H/HeJ MGP_C3HHeJ_G0025459
protein coding gene Chr2:49823388-49842100 (-)
C57BL/6NJ MGP_C57BL6NJ_G0026144
protein coding gene Chr2:51887127-51905871 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0023550
protein coding gene Chr2:46463852-46480508 (-)
CAST/EiJ MGP_CASTEiJ_G0024924
protein coding gene Chr2:49913245-49931889 (-)
CBA/J MGP_CBAJ_G0025439
protein coding gene Chr2:53809607-53828327 (-)
DBA/2J MGP_DBA2J_G0025570
protein coding gene Chr2:48106888-48124916 (-)
FVB/NJ MGP_FVBNJ_G0025532
protein coding gene Chr2:47801795-47818683 (-)
LP/J MGP_LPJ_G0025658
protein coding gene Chr2:50300816-50321325 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0025563
protein coding gene Chr2:54917643-54939608 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0026202
protein coding gene Chr2:49745086-49765220 (-)
PWK/PhJ MGP_PWKPhJ_G0024665
protein coding gene Chr2:47973683-47992692 (-)
SPRET/EiJ MGP_SPRETEiJ_G0024471
protein coding gene Chr2:49921230-49937875 (-)
WSB/EiJ MGP_WSBEiJ_G0024991
protein coding gene Chr2:50018185-50036875 (-)



Homology
more
  • Human Ortholog
    RND3, Rho family GTPase 3
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RND3, Rho family GTPase 3
  • Synonyms
    ARHE, memB, Rho8, RhoE
  • Links
    NCBI Gene ID: 390
    neXtProt AC: NX_P61587
    UniProt: P61587

  • Chr Location
    2q23.3; chr2:150468193-150539011 (-)  GRCh38

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    41 phenotypes from 3 alleles in 3 genetic backgrounds
    5 images
    22 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a mutation in this gene display premature death with postnatal growth retardation and wasting, delayed development, absence of the common peroneal nerve and impaired motor capabilities.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 74194 NCBI Gene Model | MGI Sequence Detail 18673 C57BL/6J ±  kb
    transcript NM_028810 RefSeq | MGI Sequence Detail 2827 C57BL/6  
    polypeptide P61588 UniProt | EBI | MGI Sequence Detail 244 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 11
      cDNA 11

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:2139033
    References
    more
    • Summaries
      All 65
      Developmental Gene Expression 15
      Gene Ontology 5
      Phenotypes 22
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:341979 Zhang Y, et al., Fibroblast-specific activation of Rnd3 protects against cardiac remodeling in diabetic cardiomyopathy via suppression of Notch and TGF-beta signaling. Theranostics. 2022;12(17):7250-7266

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    03/12/2024
    MGI 6.23
    The Jackson Laboratory