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Rnd3
Gene Detail
Symbol

Name
ID
Rnd3
Rho family GTPase 3
MGI:1921444
Synonyms
2610017M01Rik, Arhe, Rhoe
Feature Type
protein coding gene
Genetic Map
Chromosome 2
29.63 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr2:51130438-51149111 bp, - strand
From VEGA annotation of GRCm38

  18674 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:21074  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: RND3
Protein SuperFamily: small GTPase, Rho type
Gene Tree: Rnd3

Human
homologs
RND3, Rho family GTPase 3
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 390
neXtProt AC: NX_P61587

Human Synonyms: ARHE, memB, Rho8, RhoE

Human Chr (Location): 2q23.3; chr2:150468193-150487695 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(12) : Gene trapped(9) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a mutation in this gene display premature death with postnatal growth retardation and wasting, delayed development, absence of the common peroneal nerve and impaired motor capabilities.
 
Interactions
Rnd3 interacts with 268 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (11 annotations)
Process small GTPase mediated signal transduction
Component extracellular exosome, focal adhesion, ...
Function GTP binding, nucleotide binding, ...
External Resources: FuncBase
Expression
Literature Summary: (9 records)
Data Summary: Results (45)    Tissues (31)    Images (13)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 45
cDNA source data(9)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: GEISHA RND3 ; Xenbase rnd3 ; ZFIN rnd3b    NEW 
Molecular
reagents
All nucleic(9) cDNA(9)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000012429 (Evidence)
Ensembl Gene Model ENSMUSG00000017144 (Evidence)
Entrez Gene 74194 (Evidence)
DFCI TC1624021, TC1575622
DoTS DT.530332, DT.101277384
NIA Mouse Gene Index U022610
PDB 1GWN
Consensus CDS Project CCDS16028.1
International Mouse Phenotyping Consortium Status Rnd3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000012429 VEGA Gene Model | MGI Sequence Detail 18674 C57BL/6J ±  kb
transcript OTTMUST00000029556 VEGA | MGI Sequence Detail 2828 Not Applicable 
polypeptide OTTMUSP00000013299 VEGA | MGI Sequence Detail 244 Not Applicable 

For the selected sequences
All sequences(29) RefSeq(2) UniProt(2)
Polymorphisms
SNPs within 2kb(227 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
InterPro IPR001806 Small GTPase superfamily
InterPro IPR003578 Small GTPase superfamily, Rho type
InterPro IPR005225 Small GTP-binding protein domain
Protein Ontology PR:000014063 rho-related GTP-binding protein RhoE
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:207259 Pacary E, et al., Rnd3 coordinates early steps of cortical neurogenesis through actin-dependent and -independent mechanisms. Nat Commun. 2013;4:1635
All references(46)
Other
accession IDs
MGI:2139033

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory