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P2ry13 Gene Detail
Summary
  • Symbol
    P2ry13
  • Name
    purinergic receptor P2Y, G-protein coupled 13
  • Synonyms
    2010001L06Rik, Gpr86, P2Y13, SP174
  • Feature Type
    protein coding gene
  • IDs
    MGI:1921441
    NCBI Gene: 74191
  • Gene Overview
    MyGene.info: P2RY13
Location & Maps
more
  • Sequence Map
    Chr3:59207892-59210882 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      2991 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 29.01 cM, cytoband D
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    P2RY13, purinergic receptor P2Y13
  • Vertebrate Orthologs
    9
  • Human Ortholog
    P2RY13, purinergic receptor P2Y13
    Orthology source: HomoloGene, HGNC
  • Synonyms
    FKSG77, GPCR1, GPR86, GPR94, P2Y13, SP174
  • Links
    NCBI Gene ID: 53829
    neXtProt AC: NX_Q9BPV8

  • Chr Location
    3q24; chr3:151326308-151329549 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    13 phenotypes from 2 alleles in 2 genetic backgrounds
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    5
  • Radiation induced
    1
  • Targeted
    4
  • Genomic Mutations
    1 involving P2ry13
  • Incidental Mutations
Mice homozygous for a knock-out allele exhibit impaired bile flow, biliary cholesterol secretion, and bile acid secretion, decreased liver cholesterol level, and reduced macrophage-to-feces reverse cholesterol transport.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000052358 VEGA Gene Model | MGI Sequence Detail 2991 C57BL/6J ±  kb
transcript OTTMUST00000131400 VEGA | MGI Sequence Detail 2528 Not Applicable  
polypeptide OTTMUSP00000070267 VEGA | MGI Sequence Detail 337 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    39 from dbSNP Build 142
Protein
Information
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  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000001570 P2Y purinoceptor 13
  • InterPro Domains
    IPR017452 GPCR, rhodopsin-like, 7TM
    IPR000276 G protein-coupled receptor, rhodopsin-like
    IPR008109 P2Y13 purinoceptor
Molecular
Reagents
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  • All nucleic 17
    cDNA 17

    Microarray probesets 2
References
more
  • Summaries
    All 37
    Developmental Gene Expression 1
    Gene Ontology 6
    Phenotypes 8
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:212046 Wang N, et al., The P2Y13 receptor regulates phosphate metabolism and FGF-23 secretion with effects on skeletal development. FASEB J. 2014 May;28(5):2249-59

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/13/2016
MGI 6.05
The Jackson Laboratory