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Katnb1
Gene Detail
 Symbol
Name
ID
Katnb1
katanin p80 (WD40-containing) subunit B 1
MGI:1921437
Synonyms 2410003J24Rik, KAT
Feature Type protein coding gene
Genetic Map
Chromosome 8
47.12 cM, cytoband C5
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr8:95081201-95099874 bp, + strand
From NCBI annotation of GRCm38

  18674 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4302  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Katnb1

Human
homologs
Human Homolog KATNB1, katanin p80 (WD repeat containing) subunit B 1
NCBI Gene ID 10300
neXtProt AC  NX_Q9BVA0
Human Synonyms  KAT
Human Chr (Location)  16q21; chr16:57735715-57757250 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Chemically induced (ENU)(1) Gene trapped(6) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
An ENU-induced mutation in this gene results in male sterility with defects in male meiosis, and reduced sperm counts, abnormal sperm head shape and severely reduced sperm motility.
 
Interactions
Katnb1 interacts with 174 markers (Mir10a, Mir10b, Mir15a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (28 annotations)
Process ATP catabolic process, cell cycle, ...
Component axon, centrosome, ...
Function dynein binding, microtubule binding, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (55)    Tissues (6)    Images (22)
Theiler Stages: 23
Assay TypeResults
RNA in situ 55
cDNA source data(14)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(14) cDNA(14)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000031787 (Evidence)
Entrez Gene74187 (Evidence)
DFCITC1574398, TC1610746, TC1617574
Consensus CDS ProjectCCDS22555.1
International Mouse Knockout Project StatusKatnb1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 74187 NCBI Gene Model | MGI Sequence Detail 18674 C57BL/6J ±  kb
transcript NM_028805 RefSeq | MGI Sequence Detail 3425 C57BL/6 
polypeptide Q8BG40 UniProt | EBI | MGI Sequence Detail 658 Not Applicable 

For the selected sequences
All sequences(38) RefSeq(11) UniProt(1)
Polymorphisms SNPs within 2kb(172 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR020472 G-protein beta WD-40 repeat
InterPro IPR026962 Katanin p80 subunit B1
InterPro IPR001680 WD40 repeat
InterPro IPR019775 WD40 repeat, conserved site
InterPro IPR017986 WD40-repeat-containing domain
InterPro IPR015943 WD40/YVTN repeat-like-containing domain
Protein Ontology PR:000009245 katanin p80 WD40-containing subunit B1
Graphical View of Protein Domain Structure
References (Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:193991 Yang W, et al., Regulation of adipogenesis by cytoskeleton remodelling is facilitated by acetyltransferase MEC-17-dependent acetylation of alpha-tubulin. Biochem J. 2013 Feb 1;449(3):605-12
All references(38)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/23/2014
MGI 5.19
The Jackson Laboratory