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Katnb1
Gene Detail
Symbol

Name
ID
Katnb1
katanin p80 (WD40-containing) subunit B 1
MGI:1921437
Synonyms
2410003J24Rik, KAT
Feature Type
protein coding gene
Genetic Map
Chromosome 8
47.12 cM, cytoband C5
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr8:95081201-95099874 bp, + strand
From Ensembl annotation of GRCm38

  18674 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4302  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: KATNB1
Gene Tree: Katnb1

Human
homologs
KATNB1, katanin p80 (WD repeat containing) subunit B 1
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 10300
neXtProt AC: NX_Q9BVA0

Human Synonyms: KAT, LIS6

Human Chr (Location): 16q21; chr16:57735720-57757250 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human KATNB1

Mutations,
alleles, and
phenotypes
All mutations/alleles(11) : Chemically induced (ENU)(1) Gene trapped(6) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
An ENU-induced mutation in this gene results in male sterility with defects in male meiosis, and reduced sperm counts, abnormal sperm head shape and severely reduced sperm motility.
 
Interactions
Katnb1 interacts with 174 markers (Mir10a, Mir10b, Mir15a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (29 annotations)
Process cell cycle, cell division, ...
Component axon, centrosome, ...
Function dynein binding, microtubule binding, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (55)    Tissues (6)    Images (22)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 55
cDNA source data(14)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase katnb1 ; ZFIN katnb1    NEW 
Molecular
reagents
All nucleic(14) cDNA(14)
Microarray probesets(4)
Other database
links
Ensembl Gene Model ENSMUSG00000031787 (Evidence)
Entrez Gene 74187 (Evidence)
DFCI TC1610746, TC1574398, TC1617574
Consensus CDS Project CCDS22555.1
International Mouse Phenotyping Consortium Status Katnb1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000031787 Ensembl Gene Model | MGI Sequence Detail 18674 C57BL/6J ±  kb
transcript ENSMUST00000034239 Ensembl | MGI Sequence Detail 3425 Not Applicable 
polypeptide ENSMUSP00000034239 Ensembl | MGI Sequence Detail 658 Not Applicable 

For the selected sequences
All sequences(38) RefSeq(11) UniProt(1)
Polymorphisms
SNPs within 2kb(172 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR020472 G-protein beta WD-40 repeat
InterPro IPR026962 Katanin p80 subunit B1
InterPro IPR001680 WD40 repeat
InterPro IPR019775 WD40 repeat, conserved site
InterPro IPR017986 WD40-repeat-containing domain
InterPro IPR015943 WD40/YVTN repeat-like-containing domain
Protein Ontology PR:000009245 katanin p80 WD40-containing subunit B1
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:220901 Hu WF, et al., Katanin p80 regulates human cortical development by limiting centriole and cilia number. Neuron. 2014 Dec 17;84(6):1240-57
All references(38)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory