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Muc5b
Gene Detail
Symbol

Name
ID
Muc5b
mucin 5, subtype B, tracheobronchial
MGI:1921430
Synonyms
2300002I04Rik, MUC5, MUC9
Feature Type
protein coding gene
Genetic Map
Chromosome 7
87.29 cM, cytoband F5
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr7:141839070-141873084 bp, + strand
From VEGA annotation of GRCm38

  34015 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:136756  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 dog; 1 chicken

Gene Tree: Muc5b

Human
homologs
Human Homolog MUC5B, mucin 5B, oligomeric mucus/gel-forming
NCBI Gene ID 727897
neXtProt AC  NX_Q9HC84
Human Synonyms  MG1, MUC5, MUC-5B, MUC9
Human Chr (Location)  11p15.5; chr11:1223065-1262176 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human MUC5B
Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Gene trapped(1) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele accumulate materials in the upper and lower airways leading to chronic infection and inflammation that does not resolve and results in premature death. Macrophage function is impaired.
 
Interactions
Muc5b interacts with 253 markers (Mir15a, Mir23a, Mir27a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (5 annotations)
Process defense response to bacterium, regulation of macrophage activation
Component extracellular space, extracellular vesicular exosome
Function molecular_function
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (4)    Tissues (4)    Tissue x Stage Matrix (view)
Assay TypeResults
RT-PCR 4
cDNA source data(5)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(6) cDNA(5) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000047461 (Evidence)
Ensembl Gene ModelENSMUSG00000066108 (Evidence)
Entrez Gene74180 (Evidence)
UniGene200752
DFCITC1587839
DoTSDT.55281021
NIA Mouse Gene IndexU008972
Consensus CDS ProjectCCDS52448.1
International Mouse Knockout Project StatusMuc5b
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000047461 VEGA Gene Model | MGI Sequence Detail 34015 C57BL/6J ±  kb
transcript OTTMUST00000122520 VEGA | MGI Sequence Detail 14964 Not Applicable 
polypeptide OTTMUSP00000067184 VEGA | MGI Sequence Detail 4800 Not Applicable 

For the selected sequences
All sequences(33) RefSeq(4) UniProt(10)
Polymorphisms
SNPs within 2kb(158 from dbSNP Build 137)    SNPs within 2kb including multiple locations(162)
Protein-related
information
ResourceIDDescription
InterPro IPR006208 Cystine knot
InterPro IPR006207 Cystine knot, C-terminal
InterPro IPR002919 Trypsin Inhibitor-like, cysteine rich domain
InterPro IPR014853 Uncharacterised domain, cysteine-rich
InterPro IPR001007 von Willebrand factor, type C
InterPro IPR001846 von Willebrand factor, type D domain
InterPro IPR025155 WxxW domain
Protein Ontology PR:000010769 mucin-5B
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:207159 Roy MG, et al., Muc5b is required for airway defence. Nature. 2014 Jan 16;505(7483):412-6
All references(37)
Other
accession IDs
MGI:2142176

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory