About   Help   FAQ
Muc5b Gene Detail
Summary
  • Symbol
    Muc5b
  • Name
    mucin 5, subtype B, tracheobronchial
  • Synonyms
    2300002I04Rik, MUC5, MUC9
  • Feature Type
    protein coding gene
  • IDs
    MGI:1921430
    NCBI Gene: 74180
  • Gene Overview
    MyGene.info: MUC5B
Location & Maps
more
  • Sequence Map
    Chr7:141839070-141873084 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      34015 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 87.29 cM, cytoband F5
  • Mapping Data
    5 experiments
Homology
more
  • Human Ortholog
    MUC5B, mucin 5B, oligomeric mucus/gel-forming
  • Vertebrate Orthologs
    5
  • Human Ortholog
    MUC5B, mucin 5B, oligomeric mucus/gel-forming
    Orthology source: HomoloGene, HGNC
  • Synonyms
    MG1, MUC5, MUC-5B, MUC9
  • Links
    NCBI Gene ID: 727897
    neXtProt AC: NX_Q9HC84

  • Chr Location
    11p15.5; chr11:1223065-1262176 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human MUC5B associations

Human Disease Mouse Models
       Pulmonary Fibrosis, Idiopathic; IPF   OMIM: 178500
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    18 phenotypes from 2 alleles in 2 genetic backgrounds
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    5
  • Gene trapped
    1
  • Radiation induced
    1
  • Targeted
    2
  • Transgenic
    1
  • Genomic Mutations
    1 involving Muc5b
  • Incidental Mutations
Mice homozygous for a knock-out allele accumulate materials in the upper and lower airways leading to chronic infection and inflammation that does not resolve and results in premature death. Macrophage function is impaired.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000047461 VEGA Gene Model | MGI Sequence Detail 34015 C57BL/6J ±  kb
transcript OTTMUST00000122520 VEGA | MGI Sequence Detail 14964 Not Applicable  
polypeptide OTTMUSP00000067184 VEGA | MGI Sequence Detail 4800 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    151 from dbSNP Build 142
Protein
Information
less
  • UniProt
    5 Sequences
  • InterPro Domains
    IPR006207 Cystine knot, C-terminal
    IPR006208 Glycoprotein hormone subunit beta, cystine knot
    IPR002919 Trypsin Inhibitor-like, cysteine rich domain
    IPR014853 Uncharacterised domain, cysteine-rich
    IPR001846 von Willebrand factor, type D domain
    IPR001007 VWFC domain
    IPR025155 WxxW domain
Molecular
Reagents
less
  • All nucleic 6
    cDNA 5
    Primer pair 1

    Microarray probesets 3
Other
Accession IDs
less
MGI:2142176
References
more
  • Summaries
    All 35
    Developmental Gene Expression 4
    Gene Ontology 3
    Phenotypes 7
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:229148 Marko CK, et al., The ocular surface phenotype of Muc5ac and Muc5b null mice. Invest Ophthalmol Vis Sci. 2014 Jan;55(1):291-300

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
09/20/2016
MGI 6.05
The Jackson Laboratory