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Muc5b
Gene Detail
 Symbol
Name
ID
Muc5b
mucin 5, subtype B, tracheobronchial
MGI:1921430
Synonyms 2300002I04Rik, MUC5, MUC9
Feature Type protein coding gene
Genetic Map
Chromosome 7
87.29 cM, cytoband F5
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr7:141839072-141873085 bp, + strand
From NCBI annotation of GRCm38

  34014 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:136756  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 dog; 1 chicken

Gene Tree: Muc5b

Human
homologs
Human Homolog MUC5B, mucin 5B, oligomeric mucus/gel-forming
NCBI Gene ID 727897
neXtProt AC  NX_Q9HC84
Human Synonyms  MG1, MUC5, MUC-5B, MUC9
Human Chr (Location)  11p15.5; chr11:1223065-1262176 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human MUC5B
Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Gene trapped(1) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele accumulate materials in the upper and lower airways leading to chronic infection and inflammation that does not resolve and results in premature death. Macrophage function is impaired.
 
Interactions
Muc5b interacts with 253 markers (Mir15a, Mir23a, Mir27a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (5 annotations)
Process defense response to bacterium, regulation of macrophage activation
Component extracellular region, extracellular space
Function molecular_function
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (4)    Tissues (3)   
Theiler Stages: 28
Assay TypeResults
RT-PCR 4
cDNA source data(5)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(6) cDNA(5) Primer pair(1)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000066108 (Evidence)
Entrez Gene74180 (Evidence)
UniGene200752
DFCITC1587839
DoTSDT.55281021
NIA Mouse Gene IndexU008972
Consensus CDS ProjectCCDS52448.1
International Mouse Knockout Project StatusMuc5b
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 74180 NCBI Gene Model | MGI Sequence Detail 34014 C57BL/6J ±  kb
transcript NM_028801 RefSeq | MGI Sequence Detail 14963 C57BL/6 
polypeptide NP_083077 RefSeq | MGI Sequence Detail 4800 C57BL/6 

For the selected sequences
All sequences(25) RefSeq(4) UniProt(5)
Polymorphisms SNPs within 2kb(158 from dbSNP Build 137)    SNPs within 2kb including multiple locations(162)
Protein-related
information
ResourceIDDescription
InterPro IPR006208 Cystine knot
InterPro IPR006207 Cystine knot, C-terminal
InterPro IPR002919 Trypsin Inhibitor-like, cysteine rich domain
InterPro IPR014853 Uncharacterised domain, cysteine-rich
InterPro IPR001007 von Willebrand factor, type C
InterPro IPR001846 von Willebrand factor, type D domain
InterPro IPR025155 WxxW domain
Protein Ontology PR:000010769 mucin-5B
References (Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:207159 Roy MG, et al., Muc5b is required for airway defence. Nature. 2014 Jan 16;505(7483):412-6
All references(37)
Other
accession IDs
MGI:2142176

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory