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Gtsf1 Gene Detail
Summary
  • Symbol
    Gtsf1
  • Name
    gametocyte specific factor 1
  • Synonyms
    1700006H03Rik, Cue110
  • Feature Type
    protein coding gene
  • IDs
    MGI:1921424
    NCBI Gene: 74174
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr15:103402405-103430470 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      28066 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 15, 58.93 cM, cytoband F3
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    GTSF1, gametocyte specific factor 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    GTSF1, gametocyte specific factor 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    FAM112B
  • Links
    NCBI Gene ID: 121355
    neXtProt AC: NX_Q8WW33
    UniProt: Q8WW33

  • Chr Location
    12q13.13; chr12:54455952-54473602 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotypes from 1 allele in 1 genetic background
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit male infertility due to arrested male meiosis and apoptosis of male germ cells.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000034009 VEGA Gene Model | MGI Sequence Detail 28066 C57BL/6J ±  kb
    transcript OTTMUST00000085861 VEGA | MGI Sequence Detail 698 Not Applicable  
    polypeptide OTTMUSP00000046432 VEGA | MGI Sequence Detail 194 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      63 from dbSNP Build 142
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • InterPro Domains
      IPR007917 Gametocyte-specific factor 1, vertebrate
      IPR022776 TRM13/UPF0224 family, U11-48K-like CHHC zinc finger domain
      IPR036236 Zinc finger C2H2 superfamily
    Molecular
    Reagents
    less
    • All nucleic 41
      cDNA 37
      Primer pair 3
      Other 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 28
      Developmental Gene Expression 4
      Gene Ontology 3
      Phenotypes 6
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:261014 Yoshimura T, et al., Mouse GTSF1 is an essential factor for secondary piRNA biogenesis. EMBO Rep. 2018 Apr;19(4)

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    06/12/2018
    MGI 6.12
    The Jackson Laboratory