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Acbd5 Gene Detail
Summary
  • Symbol
    Acbd5
  • Name
    acyl-Coenzyme A binding domain containing 5
  • Synonyms
    1300014E15Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1921409
    NCBI Gene: 74159
  • Alliance
    gene page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:22958178-23004525 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 15.21 cM, cytoband A3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    77 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1921409
 protein coding gene Chr2:22958178-23005570 (+)
129S1/SvImJ MGP_129S1SvImJ_G0025395
 protein coding gene Chr2:20814527-20859894 (+)
A/J MGP_AJ_G0025373
 protein coding gene Chr2:19972151-20017425 (+)
AKR/J MGP_AKRJ_G0025342
 protein coding gene Chr2:20682233-20728924 (+)
BALB/cJ MGP_BALBcJ_G0025368
 protein coding gene Chr2:20076976-20123222 (+)
C3H/HeJ MGP_C3HHeJ_G0025129
 protein coding gene Chr2:20602565-20645305 (+)
C57BL/6NJ MGP_C57BL6NJ_G0025812
 protein coding gene Chr2:21408495-21451419 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0023226
 protein coding gene Chr2:19052226-19101123 (+)
CAST/EiJ MGP_CASTEiJ_G0024592
 protein coding gene Chr2:20517598-20561596 (+)
CBA/J MGP_CBAJ_G0025107
 protein coding gene Chr2:22228792-22283245 (+)
DBA/2J MGP_DBA2J_G0025240
 protein coding gene Chr2:19859145-19906264 (+)
FVB/NJ MGP_FVBNJ_G0025202
 protein coding gene Chr2:19643662-19688173 (+)
LP/J MGP_LPJ_G0025326
 protein coding gene Chr2:20739753-20785250 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0025233
 protein coding gene Chr2:22292470-22342569 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0025871
 protein coding gene Chr2:20576510-20613961 (+)
PWK/PhJ MGP_PWKPhJ_G0024341
 protein coding gene Chr2:19690227-19737876 (+)
SPRET/EiJ MGP_SPRETEiJ_G0024141
 protein coding gene Chr2:20681580-20732840 (+)
WSB/EiJ MGP_WSBEiJ_G0024662
 protein coding gene Chr2:20711118-20756517 (+)



Homology
more
  • Human Ortholog
    ACBD5, acyl-CoA binding domain containing 5
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ACBD5, acyl-CoA binding domain containing 5
  • Synonyms
    RDLKD
  • Links
    NCBI Gene ID: 91452
    neXtProt AC: NX_Q5T8D3
    UniProt: Q5T8D3

  • Chr Location
    10p12.1; chr10:27182624-27248674 (-)  GRCh38.p7
Human Diseases
more
  • Diseases
    1 with Acbd5 mouse models; 1 with human ACBD5 associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    42 phenotypes from 2 alleles in 2 genetic backgrounds
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit alternations in cellular lipid homeostasis in the cerebellum and liver with increased very long-chain fatty acid levels, progressive cerebellar degeneration, peroxisome abnormalities, ataxia, and develop a peroxisome disorder.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    11
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    753
  • Tissues
    11
  • cDNA Data
    9
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 74159 NCBI Gene Model | MGI Sequence Detail 46348 C57BL/6J ±  kb
    transcript NM_001355637 RefSeq | MGI Sequence Detail 3757 C57BL/6  
    polypeptide Q5XG73 UniProt | EBI | MGI Sequence Detail 508 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      8 Sequences
    • Protein Ontology
      PR:000032706 acyl-CoA-binding domain-containing protein 5
      (term hierarchy)
    • InterPro Domains
      IPR016347 Acyl-CoA-binding domain-containing protein 5
      IPR000582 Acyl-CoA-binding protein, ACBP
      IPR022408 Acyl-CoA-binding protein, ACBP, conserved site
      IPR035984 Acyl-CoA binding protein superfamily
      IPR014352 FERM/acyl-CoA-binding protein superfamily
    Molecular
    Reagents
    less
    • All nucleic 10
      cDNA 9
      Primer pair 1

      Microarray probesets 4
    References
    more
    • Summaries
      All 31
      Developmental Gene Expression 2
      Diseases 1
      Gene Ontology 3
      Phenotypes 8
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:299448 Darwisch W, et al., Cerebellar and hepatic alterations in ACBD5-deficient mice are associated with unexpected, distinct alterations in cellular lipid homeostasis. Commun Biol. 2020 Nov 26;3(1):713
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    06/23/2022
    MGI 6.20     		The Jackson Laboratory