Cluh MGI Mouse Gene Detail - MGI:1921398 - clustered mitochondria homolog

Symbol

Cluh
Name

clustered mitochondria homolog
Synonyms

1300001I01Rik

Feature Type

protein coding gene
IDs

MGI:1921398
NCBI Gene: 74148
Alliance

gene page
Transcription Start Sites

8 TSS

Sequence Map

Chr11:74540321-74561673 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 45.76 cM, cytoband B4
Mapping Data

3 experiments

SNPs within 2kb

480 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1921398	protein coding gene	Chr11:74539707-74561680 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0018696	protein coding gene	Chr11:75350337-75371691 (+)
A/J	MGP_AJ_G0018662	protein coding gene	Chr11:72563991-72585339 (+)
AKR/J	MGP_AKRJ_G0018632	protein coding gene	Chr11:74765741-74787095 (+)
BALB/cJ	MGP_BALBcJ_G0018636	protein coding gene	Chr11:72932019-72953373 (+)
C3H/HeJ	MGP_C3HHeJ_G0018449	protein coding gene	Chr11:74764252-74785606 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0019087	protein coding gene	Chr11:77724380-77745732 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016722	protein coding gene	Chr11:69580368-69602035 (+)
CAST/EiJ	MGP_CASTEiJ_G0018003	protein coding gene	Chr11:75129025-75169421 (+)
CBA/J	MGP_CBAJ_G0018419	protein coding gene	Chr11:81136206-81157560 (+)
DBA/2J	MGP_DBA2J_G0018528	protein coding gene	Chr11:72164482-72185836 (+)
FVB/NJ	MGP_FVBNJ_G0018518	protein coding gene	Chr11:71733147-71754817 (+)
LP/J	MGP_LPJ_G0018599	protein coding gene	Chr11:75951992-75973850 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018544	protein coding gene	Chr11:81750166-81771520 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019127	protein coding gene	Chr11:74958544-74979880 (+)
PWK/PhJ	MGP_PWKPhJ_G0017774	protein coding gene	Chr11:72852056-72892056 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0017565	protein coding gene	Chr11:74513431-74558004 (+)
WSB/EiJ	MGP_WSBEiJ_G0018056	protein coding gene	Chr11:74763005-74784340 (+)

Human Ortholog

CLUH, clustered mitochondria homolog

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CLUH, clustered mitochondria homolog
Synonyms

CLU1
Links

HGNC:29094

NCBI Gene ID: 23277

UniProt: O75153
Chr Location

17p13.3; chr17:2689386-2712663 (-) GRCh38

MGI Vertebrate Homology

Cluh stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: CLUH
Gene Tree

Cluh

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Phenotype Summary

36 phenotypes from 3 alleles in 3 genetic backgrounds
19 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

12
Chemically induced (other)

1
Endonuclease-mediated

5
Gene trapped

3
Targeted

3
Genomic Mutations

2 involving Cluh
Incidental Mutations

APF
Find Mice (IMSR)

50 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Constitutive homozygous KO affects liver mitochondrial function and leads to neonatal lethality. Conditional homozygous KO in the adult liver affects cellular respiration under energy stress conditions.

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All GO Annotations

15
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

901
Tissues

29
cDNA Data

201
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase cluh

ZFIN cluha

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All Sequences

82
RefSeq

8
UniProt

5
CCDS

CCDS36223.1

Ensembl

ENSMUSG00000020741 (Evidence)
NCBI Gene

74148

			Length	Strain/Species	Flank
genomic	ENSMUSG00000020741	Ensembl Gene Model \| MGI Sequence Detail	21353	C57BL/6J	± kb
transcript	ENSMUST00000092915	Ensembl \| MGI Sequence Detail	5379	Not Applicable
polypeptide	ENSMUSP00000090593	Ensembl \| MGI Sequence Detail	1353	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000059750 clustered mitochondria protein homolog

(term hierarchy)
InterPro Domains

IPR033646 CLU central domain

IPR025697 CLU domain

IPR027523 CLU domain containing protein

IPR028275 Clustered mitochondria protein, N-terminal

IPR023231 GSKIP domain superfamily

IPR011990 Tetratricopeptide-like helical domain superfamily
GlyGen

Q5SW19 1 site, 1 N-linked glycan (1 site)

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All nucleic 202

cDNA 201

Primer pair 1

Microarray probesets 4

Summaries

All 46

Developmental Gene Expression 3

Gene Ontology 6

Phenotypes 19
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:348858 Zaninello M, et al., CLUH maintains functional mitochondria and translation in motoneuronal axons and prevents peripheral neuropathy. Sci Adv. 2024 May 31;10(22):eadn2050

TSS for Cluh:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr102901	Chr11:74540288-74540346 (+)	-4 bp
Tssr102902	Chr11:74540352-74540376 (+)	43 bp
Tssr3574	Chr11:74540782-74540792 (+)	466 bp
Tssr102903	Chr11:74540799-74540810 (+)	484 bp
Tssr102904	Chr11:74541393-74541405 (+)	1,078 bp
Tssr102905	Chr11:74543969-74544005 (+)	3,666 bp
Tssr102906	Chr11:74552829-74552849 (+)	12,518 bp
Tssr102907	Chr11:74556176-74556191 (+)	15,863 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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