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Cluh Gene Detail
Summary
  • Symbol
    Cluh
  • Name
    clustered mitochondria (cluA/CLU1) homolog
  • Synonyms
    1300001I01Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1921398
    NCBI Gene: 74148
  • Gene Overview
    MyGene.info: CLUH
  • Alliance
    gene page
Location & Maps
more
  • Sequence Map
    Chr11:74649495-74670847 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      21353 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 45.76 cM, cytoband B4
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    CLUH, clustered mitochondria homolog
  • Vertebrate Orthologs
    10
  • Human Ortholog
    CLUH, clustered mitochondria homolog
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CLU1, KIAA0664
  • Links
    NCBI Gene ID: 23277
    neXtProt AC: NX_O75153
    UniProt: O75153

  • Chr Location
    17p13.3; chr17:2689386-2711633 (-)  GRCh38.p7
  • HomoloGene
    Vertebrate Homology Class 9063
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: CLUH
  • Gene Tree
    Cluh
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    22 phenotypes from 2 alleles in 2 genetic backgrounds
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Constitutive homozygous KO affects liver mitochondrial function and leads to neonatal lethality. Conditional homozygous KO in the adult liver affects cellular respiration under energy stress conditions.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    4
  • GO References
    1
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    71
  • Tissues
    9
  • cDNA Data
    200
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000006183 VEGA Gene Model | MGI Sequence Detail 21353 C57BL/6J ±  kb
    transcript OTTMUST00000013922 VEGA | MGI Sequence Detail 5379 Not Applicable  
    polypeptide OTTMUSP00000006467 VEGA | MGI Sequence Detail 1353 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      66 from dbSNP Build 142
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • InterPro Domains
      IPR033646 CLU central domain
      IPR025697 CLU domain
      IPR027523 Clustered mitochondria protein
      IPR028275 Clustered mitochondria protein, N-terminal
      IPR011990 Tetratricopeptide-like helical domain superfamily
    Molecular
    Reagents
    less
    • All nucleic 200
      cDNA 200

      Microarray probesets 4
    References
    more
    • Summaries
      All 33
      Developmental Gene Expression 2
      Gene Ontology 1
      Phenotypes 12
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:249661 Schatton D, et al., CLUH regulates mitochondrial metabolism by controlling translation and decay of target mRNAs. J Cell Biol. 2017 Mar 06;216(3):675-693
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    05/15/2018
    MGI 6.12     		The Jackson Laboratory