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Lonp1 Gene Detail
Summary
  • Symbol
    Lonp1
  • Name
    lon peptidase 1, mitochondrial
  • Synonyms
    1200017E13Rik, LON, Prss15
  • Feature Type
    protein coding gene
  • IDs
    MGI:1921392
    NCBI Gene: 74142
  • Gene Overview
    MyGene.info: LONP1
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr17:56614301-56626903 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      12603 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 29.42 cM, cytoband D
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    LONP1, lon peptidase 1, mitochondrial
  • Vertebrate Orthologs
    10
  • Human Ortholog
    LONP1, lon peptidase 1, mitochondrial
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CODASS, hLON, LON, LonHS, LONP, PIM1, PRSS15
  • Links
    NCBI Gene ID: 9361
    neXtProt AC: NX_P36776
    UniProt: P36776

  • Chr Location
    19p13.3; chr19:5691834-5720452 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    9 phenotypes from 2 alleles in 2 genetic backgrounds
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit embryonic lethality with embryonic growth retardation, small size and decreased mitochondrial DNA content. Mice heterozygous for this allele exhibit reduced chemically-induced tumors.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000041168 Ensembl Gene Model | MGI Sequence Detail 12603 C57BL/6J ±  kb
    transcript ENSMUST00000047226 Ensembl | MGI Sequence Detail 2963 Not Applicable  
    polypeptide ENSMUSP00000041814 Ensembl | MGI Sequence Detail 949 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      181 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 142
      cDNA 142

      Microarray probesets 4
    References
    more
    • Summaries
      All 41
      Developmental Gene Expression 3
      Gene Ontology 8
      Phenotypes 8
    • Earliest
      J:230404 Burks DJ, et al., IRS pleckstrin homology domains bind to acidic motifs in proteins. J Biol Chem. 1998 Nov 20;273(47):31061-7
    • Latest
      J:235644 Wu Y, et al., Mtu1-Mediated Thiouridine Formation of Mitochondrial tRNAs Is Required for Mitochondrial Translation and Is Involved in Reversible Infantile Liver Injury. PLoS Genet. 2016 Sep;12(9):e1006355

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    Funding Information
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    last database update
    05/15/2018
    MGI 6.12
    The Jackson Laboratory