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Nuak2
Gene Detail
 Symbol
Name
ID
Nuak2
NUAK family, SNF1-like kinase, 2
MGI:1921387
Synonyms 1200013B22Rik, mKIAA0537, Snark
Feature Type protein coding gene
Genetic Map
Chromosome 1
57.24 cM, cytoband E4
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr1:132316126-132333488 bp, + strand
From VEGA annotation of GRCm38

  17363 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:12539  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Nuak2

Human
homologs
Human Homolog NUAK2, NUAK family, SNF1-like kinase, 2
NCBI Gene ID 81788
neXtProt AC  NX_Q9H093
Human Synonyms  SNARK
Human Chr (Location)  1q32.1; chr1:205302059-205321755 (-)  GRCh38
Alleles
and
phenotypes
All alleles(11) : Gene trapped(5) Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Most homozygous null mice are exencephalic and die at E16.5 while survivors show a higher number of azoxymethane (AOM)-induced aberrant crypt foci (ACF) in colon. Heterozygotes show increased susceptibility to AOM-induced ACF formation and colon tumors, mature-onset obesity and metabolic disorders.
 
Gene Ontology
(GO)
classifications
All GO classifications: (20 annotations)
Process actin cytoskeleton organization, apoptotic process, ...
Function ATP binding, kinase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (94)    Tissues (22)    Images (27)
Theiler Stages: 11, 13, 15, 23
Assay TypeResults
RNA in situ 94
cDNA source data(49)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(50) cDNA(49) Primer pair(1)
Microarray probesets(2)
Other database
links
VEGA Gene ModelOTTMUSG00000021956 (Evidence)
Ensembl Gene ModelENSMUSG00000009772 (Evidence)
Entrez Gene74137 (Evidence)
UniGene100666
DFCITC1579526, TC1594793
DoTSDT.101313082, DT.40174973, DT.99840265
NIA Mouse Gene IndexU000801
EC2.7.11.1
Consensus CDS ProjectCCDS15283.1, CCDS56642.1
International Mouse Knockout Project StatusNuak2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021956 VEGA Gene Model | MGI Sequence Detail 17363 C57BL/6J ±  kb
transcript OTTMUST00000052119 VEGA | MGI Sequence Detail 2936 Not Applicable 
polypeptide OTTMUSP00000024650 VEGA | MGI Sequence Detail 639 Not Applicable 

For the selected sequences
All sequences(35) RefSeq(6) UniProt(1)
Polymorphisms SNPs within 2kb(111 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR002290 Serine/threonine- / dual specificity protein kinase, catalytic domain
InterPro IPR008271 Serine/threonine-protein kinase, active site
Protein Ontology PR:000011474 NUAK family SNF1-like kinase 2
References (Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:185597 Ohmura T, et al., Neural tube defects by NUAK1 and NUAK2 double mutation. Dev Dyn. 2012 Aug;241(8):1350-64
All references(38)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory