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Nuak2 Gene Detail
Summary
  • Symbol
    Nuak2
  • Name
    NUAK family, SNF1-like kinase, 2
  • Synonyms
    1200013B22Rik, mKIAA0537, Snark
  • Feature Type
    protein coding gene
  • IDs
    MGI:1921387
    NCBI Gene: 74137
  • Gene Overview
    MyGene.info: NUAK2
Location & Maps
more
  • Sequence Map
    Chr1:132316126-132333488 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      17363 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 57.24 cM, cytoband E4
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    NUAK2, NUAK family kinase 2
  • Vertebrate Orthologs
    9
  • Human Ortholog
    NUAK2, NUAK family kinase 2
    Orthology source: HGNC, HomoloGene
  • Synonyms
    SNARK
  • Links
    NCBI Gene ID: 81788
    neXtProt AC: NX_Q9H093

  • Chr Location
    1q32.1; chr1:205302059-205321791 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    8 phenotypes from 2 alleles in 2 genetic backgrounds
    10 phenotypes from multigenic genotypes
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    14
  • Chemically induced (other)
    2
  • Gene trapped
    5
  • Radiation induced
    1
  • Targeted
    6
  • Genomic Mutations
    3 involving Nuak2
  • Incidental Mutations
Most homozygous null mice are exencephalic and die at E16.5 while survivors show a higher number of azoxymethane (AOM)-induced aberrant crypt foci (ACF) in colon. Heterozygotes show increased susceptibility to AOM-induced ACF formation and colon tumors, mature-onset obesity and metabolic disorders.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021956 VEGA Gene Model | MGI Sequence Detail 17363 C57BL/6J ±  kb
transcript OTTMUST00000052119 VEGA | MGI Sequence Detail 2936 Not Applicable  
polypeptide OTTMUSP00000024650 VEGA | MGI Sequence Detail 639 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    111 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 50
    cDNA 49
    Primer pair 1

    Microarray probesets 2
References
more
  • Summaries
    All 36
    Developmental Gene Expression 4
    Gene Ontology 5
    Phenotypes 14
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:231180 Lessard SJ, et al., The AMPK-related kinase SNARK regulates muscle mass and myocyte survival. J Clin Invest. 2015 Dec 21;

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory