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Nuak2
Gene Detail
Symbol

Name
ID
Nuak2
NUAK family, SNF1-like kinase, 2
MGI:1921387
Synonyms
1200013B22Rik, mKIAA0537, Snark
Feature Type
protein coding gene
Genetic Map
Chromosome 1
57.24 cM, cytoband E4
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr1:132316126-132333488 bp, + strand
From VEGA annotation of GRCm38

  17363 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:12539  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: NUAK2
Gene Tree: Nuak2

Human
homologs
NUAK2, NUAK family, SNF1-like kinase, 2
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 81788
neXtProt AC: NX_Q9H093

Human Synonyms: SNARK

Human Chr (Location): 1q32.1; chr1:205302059-205321791 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(11) : Gene trapped(5) Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Most homozygous null mice are exencephalic and die at E16.5 while survivors show a higher number of azoxymethane (AOM)-induced aberrant crypt foci (ACF) in colon. Heterozygotes show increased susceptibility to AOM-induced ACF formation and colon tumors, mature-onset obesity and metabolic disorders.
 
Interactions
Nuak2 interacts with 166 markers (Mir7-1, Mir15a, Mir15b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (26 annotations)
Process actin cytoskeleton organization, apoptotic process, ...
Component AMP-activated protein kinase complex, cytoplasm
Function ATP binding, kinase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (94)    Tissues (22)    Images (27)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 94
cDNA source data(49)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase nuak2    NEW 
Molecular
reagents
All nucleic(50) cDNA(49) Primer pair(1)
Microarray probesets(2)
Other database
links
VEGA Gene Model OTTMUSG00000021956 (Evidence)
Ensembl Gene Model ENSMUSG00000009772 (Evidence)
Entrez Gene 74137 (Evidence)
UniGene 100666
DFCI TC1579526, TC1594793
DoTS DT.101313082, DT.40174973, DT.99840265
NIA Mouse Gene Index U000801
EC 2.7.11.1
Consensus CDS Project CCDS15283.1, CCDS56642.1
International Mouse Phenotyping Consortium Status Nuak2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021956 VEGA Gene Model | MGI Sequence Detail 17363 C57BL/6J ±  kb
transcript OTTMUST00000052119 VEGA | MGI Sequence Detail 2936 Not Applicable 
polypeptide OTTMUSP00000024650 VEGA | MGI Sequence Detail 639 Not Applicable 

For the selected sequences
All sequences(36) RefSeq(6) UniProt(1)
Polymorphisms
SNPs within 2kb(111 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
InterPro IPR008271 Serine/threonine-protein kinase, active site
Protein Ontology PR:000011474 NUAK family SNF1-like kinase 2
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:200007 Courchet J, et al., Terminal axon branching is regulated by the LKB1-NUAK1 kinase pathway via presynaptic mitochondrial capture. Cell. 2013 Jun 20;153(7):1510-25
All references(38)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory