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Smg8 Gene Detail
Summary
  • Symbol
    Smg8
  • Name
    smg-8 homolog, nonsense mediated mRNA decay factor (C. elegans)
  • Synonyms
    1200011M11Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1921383
    NCBI Gene: 74133
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:87077732-87086774 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 51.89 cM, cytoband C
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    25 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1921383
protein coding gene Chr11:87077732-87086777 (-)
129S1/SvImJ MGP_129S1SvImJ_G0018898
protein coding gene Chr11:88653709-88662898 (-)
A/J MGP_AJ_G0018865
protein coding gene Chr11:85247877-85257665 (-)
AKR/J MGP_AKRJ_G0018835
protein coding gene Chr11:87793199-87802556 (-)
BALB/cJ MGP_BALBcJ_G0018838
protein coding gene Chr11:85633189-85642489 (-)
C3H/HeJ MGP_C3HHeJ_G0018652
protein coding gene Chr11:87816681-87825911 (-)
C57BL/6NJ MGP_C57BL6NJ_G0019290
protein coding gene Chr11:91327833-91336871 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016923
protein coding gene Chr11:82275171-82284652 (-)
CAST/EiJ MGP_CASTEiJ_G0018207
protein coding gene Chr11:88526591-88536469 (-)
CBA/J MGP_CBAJ_G0018623
protein coding gene Chr11:95163635-95175981 (-)
DBA/2J MGP_DBA2J_G0018731
protein coding gene Chr11:84808376-84817691 (-)
FVB/NJ MGP_FVBNJ_G0018720
protein coding gene Chr11:84314567-84323463 (-)
LP/J MGP_LPJ_G0018801
protein coding gene Chr11:89145409-89160275 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0018747
protein coding gene Chr11:95256352-95266815 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0019330
protein coding gene Chr11:88037025-88046231 (-)
PWK/PhJ MGP_PWKPhJ_G0017977
protein coding gene Chr11:85620780-85630078 (-)
SPRET/EiJ MGP_SPRETEiJ_G0017769
protein coding gene Chr11:87600246-87609033 (-)
WSB/EiJ MGP_WSBEiJ_G0018258
protein coding gene Chr11:87914339-87923926 (-)



Homology
more
  • Human Ortholog
    SMG8, SMG8 nonsense mediated mRNA decay factor
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SMG8, SMG8 nonsense mediated mRNA decay factor
    Orthology source: HomoloGene, HGNC
  • Synonyms
    C17orf71
  • Links
    NCBI Gene ID: 55181
    neXtProt AC: NX_Q8ND04
    UniProt: Q8ND04

  • Chr Location
    17q22; chr17:59210010-59215250 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 32393
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: SMG8
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotype references
  • All Mutations and Alleles
    4
  • Chemically induced (other)
    1
  • Endonuclease-mediated
    1
  • Gene trapped
    1
  • Targeted
    1
  • Genomic Mutations
    2 involving Smg8
  • Incidental Mutations
    APF
  • Find Mice (IMSR)
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000020495 Ensembl Gene Model | MGI Sequence Detail 9043 C57BL/6J ±  kb
transcript ENSMUST00000020801 Ensembl | MGI Sequence Detail 3218 Not Applicable  
polypeptide ENSMUSP00000020801 Ensembl | MGI Sequence Detail 991 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 50
    cDNA 50

    Microarray probesets 3
References
more
  • Summaries
    All 31
    Gene Ontology 1
    Phenotypes 11
  • Earliest
    J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
  • Latest
    J:174216 Terzian T, et al., Rpl27a mutation in the sooty foot ataxia mouse phenocopies high p53 mouse models. J Pathol. 2011 Aug;224(4):540-52

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
10/08/2019
MGI 6.14
The Jackson Laboratory