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Dmgdh Gene Detail
Summary
  • Symbol
    Dmgdh
  • Name
    dimethylglycine dehydrogenase precursor
  • Synonyms
    1200014D15Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1921379
    NCBI Gene: 74129
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:93674436-93752823 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 13, 47.88 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    860 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1921379
protein coding gene Chr13:93674433-93752833 (+)
129S1/SvImJ MGP_129S1SvImJ_G0020828
protein coding gene Chr13:95034001-95120440 (+)
A/J MGP_AJ_G0020782
protein coding gene Chr13:91499571-91578617 (+)
AKR/J MGP_AKRJ_G0020756
protein coding gene Chr13:94288436-94374261 (+)
BALB/cJ MGP_BALBcJ_G0020779
protein coding gene Chr13:92138741-92220106 (+)
C3H/HeJ MGP_C3HHeJ_G0020572
protein coding gene Chr13:93984899-94078037 (+)
C57BL/6NJ MGP_C57BL6NJ_G0021215
protein coding gene Chr13:97932423-98026603 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0018782
protein coding gene Chr13:87356761-87435630 (+)
CAST/EiJ MGP_CASTEiJ_G0020091
protein coding gene Chr13:93242871-93323386 (+)
CBA/J MGP_CBAJ_G0020531
protein coding gene Chr13:101820880-101915508 (+)
DBA/2J MGP_DBA2J_G0020656
protein coding gene Chr13:91286647-91368150 (+)
FVB/NJ MGP_FVBNJ_G0020637
protein coding gene Chr13:90078809-90160694 (+)
LP/J MGP_LPJ_G0020731
protein coding gene Chr13:95157650-95245008 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0020665
protein coding gene Chr13:102324984-102412018 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0021255
protein coding gene Chr13:93665362-93756365 (+)
PWK/PhJ MGP_PWKPhJ_G0019843
protein coding gene Chr13:89998200-90083864 (+)
SPRET/EiJ MGP_SPRETEiJ_G0019667
protein coding gene Chr13:89954018-90038366 (+)
WSB/EiJ MGP_WSBEiJ_G0020148
protein coding gene Chr13:94174122-94260955 (+)



Homology
more
  • Human Ortholog
    DMGDH, dimethylglycine dehydrogenase
  • Vertebrate Orthologs
    9
  • Human Ortholog
    DMGDH, dimethylglycine dehydrogenase
    Orthology source: HomoloGene, HGNC
  • Synonyms
    DMGDHD, ME2GLYDH
  • Links
    NCBI Gene ID: 29958
    neXtProt AC: NX_Q9UI17
    UniProt: Q9UI17

  • Chr Location
    5q14.1; chr5:78997564-79069674 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 74129 NCBI Gene Model | MGI Sequence Detail 78388 C57BL/6J ±  kb
    transcript NM_028772 RefSeq | MGI Sequence Detail 2979 C57BL/6  
    polypeptide Q9DBT9 UniProt | EBI | MGI Sequence Detail 869 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000006538 dimethylglycine dehydrogenase, mitochondrial
    • EC
    • InterPro Domains
      IPR006222 Aminomethyltransferase, folate-binding domain
      IPR006076 FAD dependent oxidoreductase
      IPR032503 FAD dependent oxidoreductase, central domain
      IPR036188 FAD/NAD(P)-binding domain superfamily
      IPR013977 Glycine cleavage T-protein, C-terminal barrel domain
      IPR029043 Glycine cleavage T-protein/YgfZ, C-terminal
      IPR027266 GTP-binding protein TrmE/Glycine cleavage system T protein, domain 1
    Molecular
    Reagents
    less
    • All nucleic 27
      cDNA 27

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2145286
    References
    more
    • Summaries
      All 36
      Developmental Gene Expression 4
      Gene Ontology 6
      Phenotypes 7
    • Earliest
      J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
    • Latest
      J:265628 Gaudet P, et al., Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief Bioinform. 2011 Sep;12(5):449-62

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    03/13/2019
    MGI 6.13
    The Jackson Laboratory