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Dmgdh Gene Detail
Summary
  • Symbol
    Dmgdh
  • Name
    dimethylglycine dehydrogenase precursor
  • Synonyms
    1200014D15Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1921379
    NCBI Gene: 74129
Location & Maps
more
  • Sequence Map
    Chr13:93674433-93752831 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      78399 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 13, 47.88 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    DMGDH, dimethylglycine dehydrogenase
  • Vertebrate Orthologs
    9
  • Human Ortholog
    DMGDH, dimethylglycine dehydrogenase
    Orthology source: HGNC, HomoloGene
  • Synonyms
    DMGDHD, ME2GLYDH
  • Links
    NCBI Gene ID: 29958
    neXtProt AC: NX_Q9UI17

  • Chr Location
    5q14.1; chr5:78997564-79069674 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human DMGDH associations

Human Disease Mouse Models
       Dimethylglycine Dehydrogenase Deficiency; DMGDHD   OMIM: 605850
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotype references
  • All Mutations and Alleles
    4
  • Chemically induced (other)
    1
  • Gene trapped
    1
  • Targeted
    2
  • Genomic Mutations
    1 involving Dmgdh
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000024424 VEGA Gene Model | MGI Sequence Detail 78399 C57BL/6J ±  kb
transcript OTTMUST00000059874 VEGA | MGI Sequence Detail 2990 Not Applicable  
polypeptide OTTMUSP00000029163 VEGA | MGI Sequence Detail 869 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    860 from dbSNP Build 142
Protein
Information
less
  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000006538 dimethylglycine dehydrogenase, mitochondrial
  • EC
  • InterPro Domains
    IPR006076 FAD dependent oxidoreductase
    IPR032503 FAD dependent oxidoreductase, central domain
    IPR023753 FAD/NAD(P)-binding domain
    IPR013977 Glycine cleavage T-protein, C-terminal barrel domain
    IPR006222 Glycine cleavage T-protein-like, N-terminal
    IPR029043 Glycine cleavage T-protein/YgfZ, C-terminal domain
    IPR027266 GTP-binding protein TrmE/Glycine cleavage system T protein, domain 1
Molecular
Reagents
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  • All nucleic 26
    cDNA 26

    Microarray probesets 3
Other
Accession IDs
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MGI:2145286
References
more
  • Summaries
    All 31
    Developmental Gene Expression 4
    Gene Ontology 6
    Phenotypes 6
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory