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Syvn1 Gene Detail
Summary
  • Symbol
    Syvn1
  • Name
    synovial apoptosis inhibitor 1, synoviolin
  • Synonyms
    1200010C09Rik, Hrd1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1921376
    NCBI Gene: 74126
  • Gene Overview
    MyGene.info: SYVN1
  • Alliance
Location & Maps
more
  • Genetic Map
    Chromosome 19, 4.34 cM, cytoband A
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    SYVN1, synoviolin 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    SYVN1, synoviolin 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    DER3, HRD1
  • Links
    NCBI Gene ID: 84447
    neXtProt AC: NX_Q86TM6
    UniProt: Q86TM6

  • Chr Location
    11q13.1; chr11:65127279-65135178 (-)  GRCh38.p7

Human Diseases
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  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotypes from 2 alleles in 2 genetic backgrounds
    2 phenotypes from multigenic genotypes
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Haploinsufficiency results in embryonic death due to systemic abnormal apoptosis. Mice are viable when only a single copy is inactivated and they exhibit a resistance to collagen-induced arthritis due to enhanced apoptosis of synovial cells.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000032981 VEGA Gene Model | MGI Sequence Detail 7137 C57BL/6J ±  kb
    transcript OTTMUST00000082236 VEGA | MGI Sequence Detail 3159 Not Applicable  
    polypeptide OTTMUSP00000044060 VEGA | MGI Sequence Detail 612 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      69 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 138
      cDNA 138

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2147717, MGI:2147800
    References
    more
    • Summaries
      All 45
      Developmental Gene Expression 1
      Diseases 1
      Gene Ontology 11
      Phenotypes 12
    • Earliest
      J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
    • Latest
      J:240827 Xu Y, et al., The ER membrane-anchored ubiquitin ligase Hrd1 is a positive regulator of T-cell immunity. Nat Commun. 2016 Jul 15;7:12073

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    05/15/2018
    MGI 6.12
    The Jackson Laboratory