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Syvn1
Gene Detail
 Symbol
Name
ID
Syvn1
synovial apoptosis inhibitor 1, synoviolin
MGI:1921376
Synonyms 1200010C09Rik, Hrd1
Feature Type protein coding gene
Genetic Map
Chromosome 19
4.34 cM, cytoband A
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr19:6046576-6053712 bp, + strand
From VEGA annotation of GRCm38

  7137 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:32700  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

Gene Tree: Syvn1

Human
homologs
Human Homolog SYVN1, synovial apoptosis inhibitor 1, synoviolin
NCBI Gene ID 84447
neXtProt AC  NX_Q86TM6
Human Synonyms  DER3, HRD1
Human Chr (Location)  11q13; chr11:65127279-65134532 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(9) : Gene trapped(5) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Haploinsufficiency results in embryonic death due to systemic abnormal apoptosis. Mice are viable when only a single copy is inactivated and they exhibit a resistance to collagen-induced arthritis due to enhanced apoptosis of synovial cells.
 
Interactions
Syvn1 interacts with 275 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (29 annotations)
Process ER-associated ubiquitin-dependent protein catabolic process, in utero embryonic development, ...
Component endoplasmic reticulum, integral component of membrane, ...
Function acid-amino acid ligase activity, coenzyme F420-0 gamma-glutamyl ligase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (11)    Tissues (1)    Images (11)
Theiler Stages: 23
Assay TypeResults
RNA in situ 11
cDNA source data(138)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(138) cDNA(138)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000032981 (Evidence)
Ensembl Gene ModelENSMUSG00000024807 (Evidence)
Entrez Gene74126 (Evidence)
UniGene149870
DFCITC1572200, TC1736615, TC1768584
EC6.3.2.-
Consensus CDS ProjectCCDS29487.1
International Mouse Knockout Project StatusSyvn1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000032981 VEGA Gene Model | MGI Sequence Detail 7137 C57BL/6J ±  kb
transcript OTTMUST00000082235 VEGA | MGI Sequence Detail 3464 Not Applicable 
polypeptide OTTMUSP00000044059 VEGA | MGI Sequence Detail 612 Not Applicable 

For the selected sequences
All sequences(58) RefSeq(6) UniProt(4)
Polymorphisms SNPs within 2kb(65 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013083 Zinc finger, RING/FYVE/PHD-type
InterPro IPR001841 Zinc finger, RING-type
Protein Ontology PR:000015917 E3 ubiquitin-protein ligase synoviolin
References (Earliest) J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
(Latest) J:209597 Wu T, et al., Hrd1 suppresses Nrf2-mediated cellular protection during liver cirrhosis. Genes Dev. 2014 Apr 1;28(7):708-22
All references(36)
Other
accession IDs
MGI:2147717, MGI:2147800

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/16/2014
MGI 5.19
The Jackson Laboratory