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Syvn1
Gene Detail
 Symbol
Name
ID
Syvn1
synovial apoptosis inhibitor 1, synoviolin
MGI:1921376
Synonyms 1200010C09Rik, Hrd1
Feature Type protein coding gene
Genetic Map
Chromosome 19
4.34 cM, cytoband A
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr19:6046576-6053712 bp, + strand
From VEGA annotation of GRCm38

  7137 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:32700  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 zebrafish

Gene Tree: Syvn1

Human
homologs
Human Homolog SYVN1, synovial apoptosis inhibitor 1, synoviolin
NCBI Gene ID 84447
neXtProt AC  NX_Q86TM6
Human Synonyms  DER3, HRD1
Human Chr (Location)  11q13; chr11:65127279-65134532 (-)  GRCh38
Alleles
and
phenotypes
All alleles(8) : Gene trapped(5) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Haploinsufficiency results in embryonic death due to systemic abnormal apoptosis. Mice are viable when only a single copy is inactivated and they exhibit a resistance to collagen-induced arthritis due to enhanced apoptosis of synovial cells.
 
Gene Ontology
(GO)
classifications
All GO classifications: (30 annotations)
Process ER-associated ubiquitin-dependent protein catabolic process, in utero embryonic development, ...
Component endoplasmic reticulum, integral component of membrane, ...
Function acid-amino acid ligase activity, coenzyme F420-0 gamma-glutamyl ligase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (11)    Tissues (1)    Images (11)
Theiler Stages: 23
Assay TypeResults
RNA in situ 11
cDNA source data(138)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(138) cDNA(138)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000032981 (Evidence)
Ensembl Gene ModelENSMUSG00000024807 (Evidence)
Entrez Gene74126 (Evidence)
UniGene149870
DFCITC1572200, TC1736615, TC1768584
EC6.3.2.-
Consensus CDS ProjectCCDS29487.1
International Mouse Knockout Project StatusSyvn1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000032981 VEGA Gene Model | MGI Sequence Detail 7137 C57BL/6J ±  kb
transcript OTTMUST00000082236 VEGA | MGI Sequence Detail 3159 Not Applicable 
polypeptide OTTMUSP00000044060 VEGA | MGI Sequence Detail 612 Not Applicable 

For the selected sequences
All sequences(58) RefSeq(6) UniProt(4)
Polymorphisms SNPs within 2kb(65 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013083 Zinc finger, RING/FYVE/PHD-type
InterPro IPR001841 Zinc finger, RING-type
Protein Ontology PR:000015917 E3 ubiquitin-protein ligase synoviolin
References (Earliest) J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
(Latest) J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
All references(35)
Other
accession IDs
MGI:2147717, MGI:2147800

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory