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Syvn1 Gene Detail
Summary
  • Symbol
    Syvn1
  • Name
    synovial apoptosis inhibitor 1, synoviolin
  • Synonyms
    1200010C09Rik, Hrd1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1921376
    NCBI Gene: 74126
  • Gene Overview
    MyGene.info: SYVN1
  • Alliance
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:6046576-6053712 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 19, 4.34 cM, cytoband A
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    69 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1921376
protein coding gene Chr19:6046576-6053718 (.)
129S1/SvImJ MGP_129S1SvImJ_G0024737
protein coding gene Chr19:3074162-3081298 (+)
A/J MGP_AJ_G0024703
protein coding gene Chr19:2903272-2910420 (+)
AKR/J MGP_AKRJ_G0024676
protein coding gene Chr19:2993723-3000871 (+)
BALB/cJ MGP_BALBcJ_G0024703
protein coding gene Chr19:2898516-2905664 (+)
C3H/HeJ MGP_C3HHeJ_G0024471
protein coding gene Chr19:3012318-3019466 (+)
C57BL/6NJ MGP_C57BL6NJ_G0025150
protein coding gene Chr19:3133110-3140246 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022583
protein coding gene Chr19:2832902-2840013 (+)
CAST/EiJ MGP_CASTEiJ_G0023943
protein coding gene Chr19:3019903-3027062 (+)
CBA/J MGP_CBAJ_G0024443
protein coding gene Chr19:3283227-3290374 (+)
DBA/2J MGP_DBA2J_G0024570
protein coding gene Chr19:2890401-2897548 (+)
FVB/NJ MGP_FVBNJ_G0024536
protein coding gene Chr19:2902215-2909366 (+)
LP/J MGP_LPJ_G0024656
protein coding gene Chr19:3054013-3061149 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0024566
protein coding gene Chr19:3103341-3110489 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0025198
protein coding gene Chr19:3022528-3029664 (+)
PWK/PhJ MGP_PWKPhJ_G0023689
protein coding gene Chr19:2922405-2929543 (+)
SPRET/EiJ MGP_SPRETEiJ_G0023494
protein coding gene Chr19:2981665-2988810 (+)
WSB/EiJ MGP_WSBEiJ_G0024005
protein coding gene Chr19:3028309-3035463 (+)



Homology
more
  • Human Ortholog
    SYVN1, synoviolin 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    SYVN1, synoviolin 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    DER3, HRD1
  • Links
    NCBI Gene ID: 84447
    neXtProt AC: NX_Q86TM6
    UniProt: Q86TM6

  • Chr Location
    11q13.1; chr11:65127279-65135178 (-)  GRCh38.p7

Human Diseases
less
  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 2 alleles in 2 genetic backgrounds
    2 phenotypes from multigenic genotypes
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Haploinsufficiency results in embryonic death due to systemic abnormal apoptosis. Mice are viable when only a single copy is inactivated and they exhibit a resistance to collagen-induced arthritis due to enhanced apoptosis of synovial cells.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000024807 Ensembl Gene Model | MGI Sequence Detail 7137 C57BL/6J ±  kb
    transcript ENSMUST00000134667 Ensembl | MGI Sequence Detail 3159 Not Applicable  
    polypeptide ENSMUSP00000114960 Ensembl | MGI Sequence Detail 612 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 139
      cDNA 139

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2147717, MGI:2147800
    References
    more
    • Summaries
      All 45
      Developmental Gene Expression 1
      Diseases 1
      Gene Ontology 11
      Phenotypes 12
    • Earliest
      J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
    • Latest
      J:240827 Xu Y, et al., The ER membrane-anchored ubiquitin ligase Hrd1 is a positive regulator of T-cell immunity. Nat Commun. 2016 Jul 15;7:12073

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory