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Foxp4 Gene Detail
Summary
  • Symbol
    Foxp4
  • Name
    forkhead box P4
  • Synonyms
    1200010K03Rik, 2310007G05Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1921373
    NCBI Gene: 74123
  • Gene Overview
    MyGene.info: FOXP4
Location & Maps
more
  • Sequence Map
    Chr17:47867133-47924645 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      57513 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 23.99 cM, cytoband C
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    FOXP4, forkhead box P4
  • Vertebrate Orthologs
    11
  • Human Ortholog
    FOXP4, forkhead box P4
    Orthology source: HomoloGene, HGNC
  • Synonyms
    hFKHLA
  • Links
    NCBI Gene ID: 116113
    neXtProt AC: NX_Q8IVH2

  • Chr Location
    6p21.1; chr6:41546426-41602384 (+)  GRCh38.p2
  • HomoloGene
    Vertebrate Homology Class 12536
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;2 chicken;1 zebrafish;1 frog, western clawed
  • HCOP
    human homology predictions: FOXP4
  • Gene Tree
    Foxp4
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    14 phenotypes from 3 alleles in 4 genetic backgrounds
    6 phenotypes from multigenic genotypes
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene usually die before E12.5. Foregut closure is delayed leading to the development of two beating hearts and to the failure of the trachea and esophagus to separate.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    20
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    352
  • Tissues
    149
  • cDNA Data
    89
  • Literature Summary
    28
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000018348 VEGA Gene Model | MGI Sequence Detail 57513 C57BL/6J ±  kb
transcript OTTMUST00000044307 VEGA | MGI Sequence Detail 3197 Not Applicable  
polypeptide OTTMUSP00000019907 VEGA | MGI Sequence Detail 685 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    340 from dbSNP Build 142
Protein
Information
less
  • UniProt
    5 Sequences
  • InterPro Domains
    IPR001766 Fork head domain
    IPR030456 Fork head domain conserved site 2
    IPR032354 FOXP, coiled-coil domain
    IPR011991 Winged helix-turn-helix DNA-binding domain
Molecular
Reagents
less
  • All nucleic 92
    cDNA 89
    Primer pair 3

    Microarray probesets 4
Other
Accession IDs
less
MGI:1917341
References
more
  • Summaries
    All 59
    Developmental Gene Expression 28
    Gene Ontology 6
    Phenotypes 12
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:225920 Spaeth JM, et al., The FOXP1, FOXP2 and FOXP4 transcription factors are required for islet alpha cell proliferation and function in mice. Diabetologia. 2015 Aug;58(8):1836-44
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/13/2016
MGI 6.05 		The Jackson Laboratory