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Foxp4
Gene Detail
Symbol

Name
ID
Foxp4
forkhead box P4
MGI:1921373
Synonyms
1200010K03Rik, 2310007G05Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 17
23.99 cM, cytoband C
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr17:47867133-47924645 bp, - strand
From VEGA annotation of GRCm38

  57513 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:12536  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 2 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: FOXP4
Gene Tree: Foxp4

Human
homologs
FOXP4, forkhead box P4
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 116113
neXtProt AC: NX_Q8IVH2

Human Synonyms: hFKHLA

Human Chr (Location): 6p21.1; chr6:41546426-41602384 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(94) : Gene trapped(89) Targeted(5)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for disruptions in this gene usually die before E12.5. Foregut closure is delayed leading to the development of two beating hearts and to the failure of the trachea and esophagus to separate.
 
Interactions
Foxp4 interacts with 235 markers (Mir1b, Mir7-1, Mir9-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (21 annotations)
Process embryonic foregut morphogenesis, heart development, ...
Component nucleus
Function DNA binding, metal ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (27 records)
Data Summary: Results (352)    Tissues (149)    Images (63)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 12
RNA in situ 328
Northern blot 8
RT-PCR 4
cDNA source data(89)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase foxp4    NEW 
Molecular
reagents
All nucleic(92) cDNA(89) Primer pair(3)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000018348 (Evidence)
Ensembl Gene Model ENSMUSG00000023991 (Evidence)
Entrez Gene 74123 (Evidence)
UniGene 240062
DFCI TC1637002, TC1596170, TC1602350, TC1579125
DoTS DT.110569704, DT.50315958, DT.110569684, DT.528912, DT.101384443, DT.101384442
NIA Mouse Gene Index U037892
Consensus CDS Project CCDS50135.1, CCDS50136.1, CCDS50137.1
International Mouse Phenotyping Consortium Status Foxp4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000018348 VEGA Gene Model | MGI Sequence Detail 57513 C57BL/6J ±  kb
transcript OTTMUST00000044307 VEGA | MGI Sequence Detail 3197 Not Applicable 
polypeptide OTTMUSP00000019907 VEGA | MGI Sequence Detail 685 Not Applicable 

For the selected sequences
All sequences(65) RefSeq(10) UniProt(3)
Polymorphisms
SNPs within 2kb(346 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001766 Transcription factor, fork head
InterPro IPR011991 Winged helix-turn-helix DNA-binding domain
InterPro IPR015880 Zinc finger, C2H2-like
Protein Ontology PR:000007645 forkhead box protein P4
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:218833 Zhao H, et al., Foxp1/2/4 regulate endochondral ossification as a suppresser complex. Dev Biol. 2015 Feb 15;398(2):242-54
All references(61)
Other
accession IDs
MGI:1917341

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/20/2015
MGI 5.22
The Jackson Laboratory