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Foxp4
Gene Detail
Symbol

Name
ID
Foxp4
forkhead box P4
MGI:1921373
Synonyms
1200010K03Rik, 2310007G05Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 17
23.99 cM, cytoband C
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr17:47867133-47924645 bp, - strand
From VEGA annotation of GRCm38

  57513 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:12536  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 2 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Foxp4

Human
homologs
Human Homolog FOXP4, forkhead box P4
NCBI Gene ID 116113
neXtProt AC  NX_Q8IVH2
Human Synonyms  hFKHLA
Human Chr (Location)  6p21.1; chr6:41546426-41602384 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(94) : Gene trapped(89) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for disruptions in this gene usually die before E12.5. Foregut closure is delayed leading to the development of two beating hearts and to the failure of the trachea and esophagus to separate.
 
Interactions
Foxp4 interacts with 236 markers (Mir1b, Mir7-1, Mir9-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (21 annotations)
Process embryonic foregut morphogenesis, heart development, ...
Component nucleus
Function DNA binding, metal ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (26 records)
Data Summary: Results (352)    Tissues (149)    Images (63)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 12
RNA in situ 328
Northern blot 8
RT-PCR 4
cDNA source data(89)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(92) cDNA(89) Primer pair(3)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000018348 (Evidence)
Ensembl Gene ModelENSMUSG00000023991 (Evidence)
Entrez Gene74123 (Evidence)
UniGene240062
DFCITC1596170, TC1579125, TC1602350, TC1637002
DoTSDT.101384442, DT.528912, DT.101384443, DT.50315958, DT.110569684, DT.110569704
NIA Mouse Gene IndexU037892
Consensus CDS ProjectCCDS50135.1, CCDS50136.1, CCDS50137.1
International Mouse Knockout Project StatusFoxp4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000018348 VEGA Gene Model | MGI Sequence Detail 57513 C57BL/6J ±  kb
transcript OTTMUST00000044307 VEGA | MGI Sequence Detail 3197 Not Applicable 
polypeptide OTTMUSP00000019907 VEGA | MGI Sequence Detail 685 Not Applicable 

For the selected sequences
All sequences(67) RefSeq(10) UniProt(5)
Polymorphisms
SNPs within 2kb(346 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001766 Transcription factor, fork head
InterPro IPR018122 Transcription factor, fork head, conserved site
InterPro IPR011991 Winged helix-turn-helix DNA-binding domain
InterPro IPR015880 Zinc finger, C2H2-like
Protein Ontology PR:000007645 forkhead box protein P4
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:205333 Otero JJ, et al., Cerebellar cortical lamination and foliation require cyclin A2. Dev Biol. 2014 Jan 15;385(2):328-39
All references(62)
Other
accession IDs
MGI:1917341

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/16/2014
MGI 5.20
The Jackson Laboratory