Foxp4
Gene Detail

Symbol

Name
ID

Foxp4
forkhead box P4
MGI:1921373

Synonyms

1200010K03Rik, 2310007G05Rik

Feature Type

protein coding gene

Genetic Map

Chromosome 17
23.99 cM, cytoband C
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr17:47867133-47924645 bp, - strand From VEGA annotation of GRCm38   57513 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate
homology

HomoloGene:12536  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 2 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Foxp4

Human
homologs

Human Homolog		FOXP4, forkhead box P4
NCBI Gene ID		116113
neXtProt AC		NX_Q8IVH2
Human Synonyms		hFKHLA
Human Chr (Location)		6p21.1; chr6:41546426-41602384 (+)  GRCh38

Mutations,
alleles, and
phenotypes

All mutations/alleles(94) : Gene trapped(89) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 

Mice homozygous for disruptions in this gene usually die before E12.5. Foregut closure is delayed leading to the development of two beating hearts and to the failure of the trachea and esophagus to separate.

 

Interactions

Foxp4 interacts with 236 markers (Mir1b, Mir7-1, Mir9-1, ...)

View All

Gene Ontology
(GO)
classifications

All GO classifications: (21 annotations)

Process	embryonic foregut morphogenesis, heart development, ...
Component	nucleus
Function	DNA binding, metal ion binding, ...

External Resources: FuncBase

Expression

Literature Summary: (26 records)

Data Summary: Results (352)    Tissues (149)    Images (63)    Tissue x Stage Matrix (view)

Assay Type	Results
Immunohistochemistry	12
RNA in situ	328
Northern blot	8
RT-PCR	4

cDNA source data(89)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas

Molecular
reagents

All nucleic(92) cDNA(89) Primer pair(3)
Microarray probesets(4)

Other database
links

VEGA Gene Model	OTTMUSG00000018348 (Evidence)
Ensembl Gene Model	ENSMUSG00000023991 (Evidence)
Entrez Gene	74123 (Evidence)
UniGene	240062
DFCI	TC1579125, TC1637002, TC1602350, TC1596170
DoTS	DT.110569684, DT.101384443, DT.101384442, DT.528912, DT.110569704, DT.50315958
NIA Mouse Gene Index	U037892
Consensus CDS Project	CCDS50135.1, CCDS50136.1, CCDS50137.1
International Mouse Knockout Project Status	Foxp4

Sequences

Length	Strain/Species
genomic	OTTMUSG00000018348	VEGA Gene Model | MGI Sequence Detail	57513	C57BL/6J
transcript	OTTMUST00000044307	VEGA | MGI Sequence Detail	3197	Not Applicable
polypeptide	OTTMUSP00000019907	VEGA | MGI Sequence Detail	685	Not Applicable

All sequences(67) RefSeq(10) UniProt(5)

Polymorphisms

SNPs within 2kb(346 from dbSNP Build 137)

Protein-related
information

Resource	ID	Description
InterPro	IPR001766	Transcription factor, fork head
InterPro	IPR018122	Transcription factor, fork head, conserved site
InterPro	IPR011991	Winged helix-turn-helix DNA-binding domain
InterPro	IPR015880	Zinc finger, C2H2-like
Protein Ontology	PR:000007645	forkhead box protein P4

References

(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:205333 Otero JJ, et al., Cerebellar cortical lamination and foliation require cyclin A2. Dev Biol. 2014 Jan 15;385(2):328-39
All references(62)

Other
accession IDs

MGI:1917341