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Foxp4 Gene Detail
Summary
  • Symbol
    Foxp4
  • Name
    forkhead box P4
  • Synonyms
    1200010K03Rik, 2310007G05Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1921373
    NCBI Gene: 74123
  • Alliance
  • Transcription Start Sites
    19 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:48178058-48235401 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 17, 23.99 cM, cytoband C
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    340 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1921373
protein coding gene Chr17:48178058-48235570 (-)
129S1/SvImJ MGP_129S1SvImJ_G0023859
protein coding gene Chr17:49117113-49179274 (-)
A/J MGP_AJ_G0023819
protein coding gene Chr17:47825421-47886848 (-)
AKR/J MGP_AKRJ_G0023788
protein coding gene Chr17:48247981-48309745 (-)
BALB/cJ MGP_BALBcJ_G0023821
protein coding gene Chr17:47743795-47802534 (-)
C3H/HeJ MGP_C3HHeJ_G0023584
protein coding gene Chr17:48986530-49046307 (-)
C57BL/6NJ MGP_C57BL6NJ_G0024265
protein coding gene Chr17:51147471-51208710 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021714
protein coding gene Chr17:44582347-44640312 (-)
CAST/EiJ MGP_CASTEiJ_G0023066
protein coding gene Chr17:49110609-49172842 (-)
CBA/J MGP_CBAJ_G0023561
protein coding gene Chr17:53017364-53079404 (-)
DBA/2J MGP_DBA2J_G0023689
protein coding gene Chr17:46581081-46639634 (-)
FVB/NJ MGP_FVBNJ_G0023655
protein coding gene Chr17:46241868-46299933 (-)
LP/J MGP_LPJ_G0023769
protein coding gene Chr17:49755670-49823540 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0023683
protein coding gene Chr17:52459548-52518998 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0024310
protein coding gene Chr17:48607434-48672640 (-)
PWK/PhJ MGP_PWKPhJ_G0022811
protein coding gene Chr17:45966118-46026797 (-)
SPRET/EiJ MGP_SPRETEiJ_G0022626
protein coding gene Chr17:45500971-45565280 (-)
WSB/EiJ MGP_WSBEiJ_G0023131
protein coding gene Chr17:49188358-49255946 (-)



Homology
more
  • Human Ortholog
    FOXP4, forkhead box P4
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FOXP4, forkhead box P4
  • Synonyms
    hFKHLA
  • Links
    NCBI Gene ID: 116113
    neXtProt AC: NX_Q8IVH2
    UniProt: Q8IVH2

  • Chr Location
    6p21.1; chr6:41546381-41602384 (+)  GRCh38

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    14 phenotypes from 3 alleles in 4 genetic backgrounds
    6 phenotypes from multigenic genotypes
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene usually die before E12.5. Foregut closure is delayed leading to the development of two beating hearts and to the failure of the trachea and esophagus to separate.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 74123 NCBI Gene Model | MGI Sequence Detail 57344 C57BL/6J ±  kb
    transcript NM_001403970 RefSeq | MGI Sequence Detail 3854 C57BL/6  
    polypeptide Q9DBY0 UniProt | EBI | MGI Sequence Detail 795 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 98
      cDNA 92
      Primer pair 4
      Other 2

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1917341
    References
    more
    • Summaries
      All 76
      Developmental Gene Expression 39
      Gene Ontology 6
      Phenotypes 18
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:336866 Puelles L, et al., The Midbrain Preisthmus: A Poorly Known Effect of the Isthmic Organizer. Int J Mol Sci. 2023 Jun 5;24(11)

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    03/12/2024
    MGI 6.23
    The Jackson Laboratory