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Foxp4 Gene Detail
Summary
  • Symbol
    Foxp4
  • Name
    forkhead box P4
  • Synonyms
    1200010K03Rik, 2310007G05Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1921373
    NCBI Gene: 74123
  • Gene Overview
    MyGene.info: FOXP4
  • Alliance
    gene page
  • Transcription Start Sites
    15 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:47867133-47924643 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 23.99 cM, cytoband C
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    340 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1921373
 protein coding gene Chr17:47867133-47924645 (-)
129S1/SvImJ MGP_129S1SvImJ_G0023859
 protein coding gene Chr17:49117113-49179274 (-)
A/J MGP_AJ_G0023819
 protein coding gene Chr17:47825421-47886848 (-)
AKR/J MGP_AKRJ_G0023788
 protein coding gene Chr17:48247981-48309745 (-)
BALB/cJ MGP_BALBcJ_G0023821
 protein coding gene Chr17:47743795-47802534 (-)
C3H/HeJ MGP_C3HHeJ_G0023584
 protein coding gene Chr17:48986530-49046307 (-)
C57BL/6NJ MGP_C57BL6NJ_G0024265
 protein coding gene Chr17:51147471-51208710 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021714
 protein coding gene Chr17:44582347-44640312 (-)
CAST/EiJ MGP_CASTEiJ_G0023066
 protein coding gene Chr17:49110609-49172842 (-)
CBA/J MGP_CBAJ_G0023561
 protein coding gene Chr17:53017364-53079404 (-)
DBA/2J MGP_DBA2J_G0023689
 protein coding gene Chr17:46581081-46639634 (-)
FVB/NJ MGP_FVBNJ_G0023655
 protein coding gene Chr17:46241868-46299933 (-)
LP/J MGP_LPJ_G0023769
 protein coding gene Chr17:49755670-49823540 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0023683
 protein coding gene Chr17:52459548-52518998 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0024310
 protein coding gene Chr17:48607434-48672640 (-)
PWK/PhJ MGP_PWKPhJ_G0022811
 protein coding gene Chr17:45966118-46026797 (-)
SPRET/EiJ MGP_SPRETEiJ_G0022626
 protein coding gene Chr17:45500971-45565280 (-)
WSB/EiJ MGP_WSBEiJ_G0023131
 protein coding gene Chr17:49188358-49255946 (-)



Homology
more
  • Human Ortholog
    FOXP4, forkhead box P4
  • Vertebrate Orthologs
    11
  • Human Ortholog
    FOXP4, forkhead box P4
    Orthology source: HomoloGene, HGNC
  • Synonyms
    hFKHLA
  • Links
    NCBI Gene ID: 116113
    neXtProt AC: NX_Q8IVH2
    UniProt: Q8IVH2

  • Chr Location
    6p21.1; chr6:41546426-41602384 (+)  GRCh38.p7
  • HomoloGene
    Vertebrate Homology Class 12536
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;2 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: FOXP4
  • Gene Tree
    Foxp4
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    14 phenotypes from 3 alleles in 4 genetic backgrounds
    6 phenotypes from multigenic genotypes
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene usually die before E12.5. Foregut closure is delayed leading to the development of two beating hearts and to the failure of the trachea and esophagus to separate.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    18
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    359
  • Tissues
    153
  • cDNA Data
    90
  • Literature Summary
    32
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 74123 NCBI Gene Model | MGI Sequence Detail 57511 C57BL/6J ±  kb
    transcript NM_001110824 RefSeq | MGI Sequence Detail 4056 C57BL/6  
    polypeptide Q9DBY0 UniProt | EBI | MGI Sequence Detail 795 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • InterPro Domains
      IPR001766 Fork head domain
      IPR030456 Fork head domain conserved site 2
      IPR032354 FOXP, coiled-coil domain
      IPR036390 Winged helix DNA-binding domain superfamily
      IPR036388 Winged helix-like DNA-binding domain superfamily
    Molecular
    Reagents
    less
    • All nucleic 93
      cDNA 90
      Primer pair 3

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1917341
    References
    more
    • Summaries
      All 65
      Developmental Gene Expression 32
      Gene Ontology 5
      Phenotypes 15
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:256739 Dean ED, et al., Interrupted Glucagon Signaling Reveals Hepatic alpha Cell Axis and Role for L-Glutamine in alpha Cell Proliferation. Cell Metab. 2017 Jun 6;25(6):1362-1373.e5
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    01/08/2019
    MGI 6.13     		The Jackson Laboratory