Acoxl MGI Mouse Gene Detail - MGI:1921371 - acyl-Coenzyme A oxidase-like

Symbol

Acoxl
Name

acyl-Coenzyme A oxidase-like
Synonyms

1200014P05Rik

Feature Type

protein coding gene
IDs

MGI:1921371
NCBI Gene: 74121
Alliance

gene page
Transcription Start Sites

8 TSS

Sequence Map

Chr2:127680796-127965793 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 62.10 cM
Mapping Data

2 experiments

SNPs within 2kb

2378 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1921371	protein coding gene	Chr2:127680717-127968172 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0026470	protein coding gene	Chr2:131127670-131441410 (+)
A/J	MGP_AJ_G0026434	protein coding gene	Chr2:125822151-126123210 (+)
AKR/J	MGP_AKRJ_G0026409	protein coding gene	Chr2:129422977-129715047 (+)
BALB/cJ	MGP_BALBcJ_G0026446	protein coding gene	Chr2:126088747-126381298 (+)
C3H/HeJ	MGP_C3HHeJ_G0026189	protein coding gene	Chr2:129919590-130225622 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0026891	protein coding gene	Chr2:135251009-135556968 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0024268	protein coding gene	Chr2:120658473-120952017 (+)
CAST/EiJ	MGP_CASTEiJ_G0025650	protein coding gene	Chr2:130130675-130438598 (+)
CBA/J	MGP_CBAJ_G0026169	protein coding gene	Chr2:140260546-140579818 (+)
DBA/2J	MGP_DBA2J_G0026303	protein coding gene	Chr2:125221542-125519500 (+)
FVB/NJ	MGP_FVBNJ_G0026267	protein coding gene	Chr2:123880207-124164524 (+)
LP/J	MGP_LPJ_G0026408	protein coding gene	Chr2:131377237-131680058 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0026287	protein coding gene	Chr2:144262223-144564072 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0026946	protein coding gene	Chr2:129433128-129733731 (+)
PWK/PhJ	MGP_PWKPhJ_G0025386	protein coding gene	Chr2:124788967-125082367 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0025188	protein coding gene	Chr2:128529460-128835232 (+)
WSB/EiJ	MGP_WSBEiJ_G0025724	protein coding gene	Chr2:130341277-130644383 (+)

Human Ortholog

ACOXL, acyl-CoA oxidase like

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ACOXL, acyl-CoA oxidase like
Synonyms

ACOX4
Links

HGNC:25621

NCBI Gene ID: 55289

neXtProt AC: NX_Q9NUZ1

UniProt: Q9NUZ1
Chr Location

2q13; chr2:110732539-111118548 (+) GRCh38

MGI Vertebrate Homology

Acoxl stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: ACOXL
Protein SuperFamily

Acyl-CoA_oxidase
Gene Tree

Acoxl

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Phenotype Summary

18 phenotypes from 1 allele in 1 genetic background
9 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

9
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

3
Radiation induced

1
Targeted

2
Genomic Mutations

2 involving Acoxl
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

40 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

7
GO References

2

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

6

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase acoxl

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All Sequences

39
RefSeq

6
UniProt

1
CCDS

CCDS16711.1

Ensembl

ENSMUSG00000027380 (Evidence)
NCBI Gene

74121

			Length	Strain/Species	Flank
genomic	ENSMUSG00000027380	Ensembl Gene Model \| MGI Sequence Detail	284998	C57BL/6J	± kb
transcript	ENSMUST00000028859	Ensembl \| MGI Sequence Detail	2842	Not Applicable
polypeptide	ENSMUSP00000028859	Ensembl \| MGI Sequence Detail	632	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000003645 acyl-coenzyme A oxidase-like protein

(term hierarchy)
EC

1.3.3.-
InterPro Domains

IPR036250 Acyl-CoA dehydrogenase-like, C-terminal

IPR009075 Acyl-CoA dehydrogenase/oxidase, C-terminal

IPR009100 Acyl-CoA dehydrogenase/oxidase, N-terminal and middle domain superfamily

IPR012258 Acyl-CoA oxidase

IPR002655 Acyl-CoA oxidase, C-terminal

IPR006091 Acyl-CoA oxidase/dehydrogenase, middle domain

IPR046373 Acyl-CoA oxidase/dehydrogenase, middle domain superfamily

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All nucleic 6

cDNA 6

Microarray probesets 4

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MGI:2139241

Summaries

All 28

Gene Ontology 2

Phenotypes 9
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14

TSS for Acoxl:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr20035	Chr2:127680704-127680719 (+)	-84 bp
Tssr20036	Chr2:127680734-127680756 (+)	-51 bp
Tssr20037	Chr2:127857103-127857107 (+)	176,309 bp
Tssr20038	Chr2:127897091-127897104 (+)	216,302 bp
Tssr20039	Chr2:127897111-127897122 (+)	216,321 bp
Tssr20040	Chr2:127905020-127905029 (+)	224,229 bp
Tssr20041	Chr2:127905041-127905059 (+)	224,254 bp
Tssr638	Chr2:127956296-127956299 (+)	275,502 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23