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Actr3 Gene Detail
Summary
  • Symbol
    Actr3
  • Name
    ARP3 actin-related protein 3
  • Synonyms
    1200003A09Rik, Arp3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1921367
    NCBI Gene: 74117
  • Gene Overview
    MyGene.info: ACTR3
  • Alliance
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:125392905-125435727 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 54.70 cM, cytoband E3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    242 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1921367
protein coding gene Chr1:125392905-125435727 (-)
129S1/SvImJ MGP_129S1SvImJ_G0016414
protein coding gene Chr1:128479717-128524372 (-)
A/J MGP_AJ_G0016397
protein coding gene Chr1:123752322-123798413 (-)
AKR/J MGP_AKRJ_G0016362
protein coding gene Chr1:127382336-127426792 (-)
BALB/cJ MGP_BALBcJ_G0016357
protein coding gene Chr1:124101470-124146506 (-)
C3H/HeJ MGP_C3HHeJ_G0016183
protein coding gene Chr1:127572576-127622120 (-)
C57BL/6NJ MGP_C57BL6NJ_G0016818
protein coding gene Chr1:133335417-133380337 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014531
protein coding gene Chr1:117160317-117203054 (-)
CAST/EiJ MGP_CASTEiJ_G0015764
protein coding gene Chr1:126468588-126515324 (-)
CBA/J MGP_CBAJ_G0016156
protein coding gene Chr1:137859418-137906246 (-)
DBA/2J MGP_DBA2J_G0016262
protein coding gene Chr1:122760563-122803708 (-)
FVB/NJ MGP_FVBNJ_G0016261
protein coding gene Chr1:121496597-121540493 (-)
LP/J MGP_LPJ_G0016333
protein coding gene Chr1:129821771-129864705 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0016286
protein coding gene Chr1:143785644-143833860 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0016854
protein coding gene Chr1:127148855-127193697 (-)
PWK/PhJ MGP_PWKPhJ_G0015550
protein coding gene Chr1:121729212-121774073 (-)
SPRET/EiJ MGP_SPRETEiJ_G0015338
protein coding gene Chr1:126086416-126130379 (-)
WSB/EiJ MGP_WSBEiJ_G0015826
protein coding gene Chr1:127087590-127132396 (-)



Homology
more
  • Human Ortholog
    ACTR3, ARP3 actin related protein 3 homolog
  • Vertebrate Orthologs
    9
  • Human Ortholog
    ACTR3, ARP3 actin related protein 3 homolog
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ARP3
  • Links
    NCBI Gene ID: 10096
    neXtProt AC: NX_P61158
    UniProt: P61158

  • Chr Location
    2q14.1; chr2:113889934-113961554 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele die prior to E4.5 and exhibit abnormal embryogenesis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 74117 NCBI Gene Model | MGI Sequence Detail 42823 C57BL/6J ±  kb
    transcript NM_023735 RefSeq | MGI Sequence Detail 2746 C57BL/6  
    polypeptide Q99JY9 UniProt | EBI | MGI Sequence Detail 418 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 323
      cDNA 323

      Microarray probesets 6
    References
    more
    • Summaries
      All 60
      Developmental Gene Expression 4
      Gene Ontology 13
      Phenotypes 9
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:237336 Gokhale A, et al., The Proteome of BLOC-1 Genetic Defects Identifies the Arp2/3 Actin Polymerization Complex to Function Downstream of the Schizophrenia Susceptibility Factor Dysbindin at the Synapse. J Neurosci. 2016 Dec 07;36(49):12393-12411

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory