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Pi16 Gene Detail
Summary
  • Symbol
    Pi16
  • Name
    peptidase inhibitor 16
  • Synonyms
    1200009H11Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1921366
    NCBI Gene: 74116
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:29318796-29328903 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 15.22 cM, cytoband B1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    81 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1921366
protein coding gene Chr17:29318796-29329413 (.)
129S1/SvImJ MGP_129S1SvImJ_G0023462
protein coding gene Chr17:28842903-28854437 (+)
A/J MGP_AJ_G0023420
protein coding gene Chr17:27854232-27864487 (+)
AKR/J MGP_AKRJ_G0023385
protein coding gene Chr17:28083398-28095888 (+)
BALB/cJ MGP_BALBcJ_G0023425
protein coding gene Chr17:28115460-28127781 (+)
C3H/HeJ MGP_C3HHeJ_G0023186
protein coding gene Chr17:28472807-28483632 (+)
C57BL/6NJ MGP_C57BL6NJ_G0023867
protein coding gene Chr17:29988007-29998883 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021342
protein coding gene Chr17:25178210-25187959 (+)
CAST/EiJ MGP_CASTEiJ_G0022687
protein coding gene Chr17:28447575-28458581 (+)
CBA/J MGP_CBAJ_G0023161
protein coding gene Chr17:31099049-31109319 (+)
DBA/2J MGP_DBA2J_G0023291
protein coding gene Chr17:27376918-27387181 (+)
FVB/NJ MGP_FVBNJ_G0023261
protein coding gene Chr17:27217916-27227650 (+)
LP/J MGP_LPJ_G0023369
protein coding gene Chr17:29093203-29105373 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0023279
protein coding gene Chr17:30442276-30455330 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0023909
protein coding gene Chr17:28550296-28563534 (+)
PWK/PhJ MGP_PWKPhJ_G0022437
protein coding gene Chr17:26220830-26230779 (+)
SPRET/EiJ MGP_SPRETEiJ_G0022255
protein coding gene Chr17:26528006-26538914 (+)
WSB/EiJ MGP_WSBEiJ_G0022749
protein coding gene Chr17:28503288-28516312 (+)



Homology
more
  • Human Ortholog
    PI16, peptidase inhibitor 16
  • Vertebrate Orthologs
    7
  • Human Ortholog
    PI16, peptidase inhibitor 16
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CD364, CRISP9, MSMBBP, PSPBP
  • Links
    NCBI Gene ID: 221476
    neXtProt AC: NX_Q6UXB8
    UniProt: Q6UXB8

  • Chr Location
    6p21.2; chr6:36948263-36964837 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    9 phenotypes from 2 alleles in 2 genetic backgrounds
    5 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous mutant mice exhibited numerous immunological abnormalities during tissue-specific FACS analyses including an increased percentage of CD25+ cells in lymph node and B cell compartment differences in bone marrow spleen and lymph node.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 74116 NCBI Gene Model | MGI Sequence Detail 10108 C57BL/6J ±  kb
    transcript NM_023734 RefSeq | MGI Sequence Detail 2245 C57BL/6  
    polypeptide Q9ET66 UniProt | EBI | MGI Sequence Detail 498 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • InterPro Domains
      IPR018244 Allergen V5/Tpx-1-related, conserved site
      IPR014044 CAP domain
      IPR035940 CAP superfamily
      IPR001283 Cysteine-rich secretory protein, allergen V5/Tpx-1-related
      IPR034124 Peptidase inhibitor 16-like, SCP domain
    Molecular
    Reagents
    less
    • All nucleic 19
      Genomic 2
      cDNA 17

      Microarray probesets 4
    References
    more
    • Summaries
      All 28
      Developmental Gene Expression 1
      Gene Ontology 5
      Phenotypes 5
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:244259 Regn M, et al., Peptidase inhibitor 16 is a membrane-tethered regulator of chemerin processing in the myocardium. J Mol Cell Cardiol. 2016 Oct;99:57-64

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
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    last database update
    11/13/2018
    MGI 6.13
    The Jackson Laboratory