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Crot Gene Detail
Summary
  • Symbol
    Crot
  • Name
    carnitine O-octanoyltransferase
  • Synonyms
    1200003H03Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1921364
    NCBI Gene: 74114
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:9016033-9047324 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 3.50 cM, cytoband A1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    196 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1921364
 protein coding gene Chr5:9016033-9047926 (-)
129S1/SvImJ MGP_129S1SvImJ_G0029289
 protein coding gene Chr5:5957956-5989943 (-)
A/J MGP_AJ_G0029252
 protein coding gene Chr5:5806736-5838547 (-)
AKR/J MGP_AKRJ_G0029201
 protein coding gene Chr5:5897289-5930184 (-)
BALB/cJ MGP_BALBcJ_G0029269
 protein coding gene Chr5:5986274-6017619 (-)
C3H/HeJ MGP_C3HHeJ_G0028989
 protein coding gene Chr5:6127974-6159139 (-)
C57BL/6NJ MGP_C57BL6NJ_G0029719
 protein coding gene Chr5:6515581-6547859 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026962
 protein coding gene Chr5:5539734-5569223 (-)
CAST/EiJ MGP_CASTEiJ_G0028402
 protein coding gene Chr5:5952658-5987470 (-)
CBA/J MGP_CBAJ_G0028950
 protein coding gene Chr5:6642800-6683310 (-)
DBA/2J MGP_DBA2J_G0029104
 protein coding gene Chr5:5915864-5947226 (-)
FVB/NJ MGP_FVBNJ_G0029066
 protein coding gene Chr5:5671156-5702992 (-)
LP/J MGP_LPJ_G0029193
 protein coding gene Chr5:6104906-6138418 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0029094
 protein coding gene Chr5:6630577-6666120 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0029750
 protein coding gene Chr5:5902478-5935807 (-)
PWK/PhJ MGP_PWKPhJ_G0028124
 protein coding gene Chr5:5699721-5731697 (-)
SPRET/EiJ MGP_SPRETEiJ_G0027957
 protein coding gene Chr5:6082427-6118104 (-)
WSB/EiJ MGP_WSBEiJ_G0028482
 protein coding gene Chr5:5923785-5956321 (-)



Homology
more
  • Human Ortholog
    CROT, carnitine O-octanoyltransferase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CROT, carnitine O-octanoyltransferase
  • Synonyms
    COT
  • Links
    NCBI Gene ID: 54677
    neXtProt AC: NX_Q9UKG9
    UniProt: Q9UKG9

  • Chr Location
    7q21.12; chr7:87345664-87399794 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 2 alleles in 2 genetic backgrounds
    3 phenotypes from multigenic genotypes
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit normal gross anatomy. Mice homozygous for a null allele and Ldlr null allele exhibit reduced arterial calcification without alteration in bone density.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    22
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    826
  • Tissues
    112
  • cDNA Data
    104
  • Literature Summary
    3
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000003623 Ensembl Gene Model | MGI Sequence Detail 31292 C57BL/6J ±  kb
transcript ENSMUST00000003720 Ensembl | MGI Sequence Detail 2996 Not Applicable  
polypeptide ENSMUSP00000003720 Ensembl | MGI Sequence Detail 612 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 106
    cDNA 104
    Primer pair 1
    Other 1

    Microarray probesets 3
References
more
  • Summaries
    All 38
    Developmental Gene Expression 3
    Gene Ontology 8
    Phenotypes 6
  • Earliest
    J:72469 Farrell SO, et al., Properties of purified carnitine acyltransferases of mouse liver peroxisomes. J Biol Chem. 1984 Nov 10;259(21):13089-95
  • Latest
    J:331161 Okui T, et al., CROT (Carnitine O-Octanoyltransferase) Is a Novel Contributing Factor in Vascular Calcification via Promoting Fatty Acid Metabolism and Mitochondrial Dysfunction. Arterioscler Thromb Vasc Biol. 2021 Feb;41(2):755-768
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory