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Usp16 Gene Detail
Summary
  • Symbol
    Usp16
  • Name
    ubiquitin specific peptidase 16
  • Synonyms
    1200004E02Rik, 2810483I07Rik, 6330514E22Rik, UBP-M
  • Feature Type
    protein coding gene
  • IDs
    MGI:1921362
    NCBI Gene: 74112
  • Alliance
    genome feature page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:87251833-87280403 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 49.54 cM, cytoband C3.3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    891 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1921362
 protein coding gene Chr16:87251591-87280405 (+)
129S1/SvImJ ENSMUSG00200036627
 protein coding gene Chr16:84115700-84144504 (+)
A/J ENSMUSG00195025774
 protein coding gene Chr16:83917658-83946664 (+)
AKR/J ENSMUSG00220015418
 protein coding gene Chr16:84118866-84147676 (+)
BALB/cJ ENSMUSG00180014405
 protein coding gene Chr16:83999530-84028343 (+)
C3H/HeJ ENSMUSG00175014260
 protein coding gene Chr16:84325313-84354318 (+)
C57BL/6NJ ENSMUSG00215021404
 protein coding gene Chr16:84131800-84160619 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020899
 protein coding gene Chr16:81959916-81991077 (+)
CAST/EiJ ENSTCUG00005019709
 protein coding gene Chr16:83691724-83720475 (+)
CBA/J ENSMUSG00210036753
 protein coding gene Chr16:84225382-84254191 (+)
DBA/2J ENSMUSG00185032266
 protein coding gene Chr16:84178377-84207193 (+)
FVB/NJ ENSMUSG00205015104
 protein coding gene Chr16:83968815-83997824 (+)
JF1/MsJ ENSUMUG00000026629
 protein coding gene Chr16:84272084-84300658 (+)
LP/J ENSMUSG00230032551
 protein coding gene Chr16:86676768-86705571 (+)
NOD/ShiLtJ ENSMUSG00190023216
 protein coding gene Chr16:84134496-84163501 (+)
NZO/HlLtJ ENSMUSG00225030677
 protein coding gene Chr16:89855903-89884713 (+)
PWK/PhJ ENSLUMG00010012048
 protein coding gene Chr16:83929776-83958776 (+)
SPRET/EiJ ENSMSPG00010029084
 protein coding gene Chr16:85045931-85074714 (+)
WSB/EiJ ENSIUOG00005018488
 protein coding gene Chr16:84125007-84154013 (+)



Homology
more
  • Human Ortholog
    USP16, ubiquitin specific peptidase 16
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    USP16, ubiquitin specific peptidase 16
  • Synonyms
    UBP-M, UBPM
  • Links
    NCBI Gene ID: 10600
    UniProt: Q9Y5T5

  • Chr Location
    21q21.3; chr21:29024629-29054493 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 2 alleles in 2 genetic backgrounds
    25 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a transgenic gene disruption exhibit embryonic lethality at E6.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    76
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    812
  • Tissues
    148
  • cDNA Data
    115
  • Literature Summary
    4
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 74112 NCBI Gene Model | MGI Sequence Detail 28571 C57BL/6J ±  kb
transcript NM_024258 RefSeq | MGI Sequence Detail 2926 C57BL/6  
polypeptide Q99LG0 UniProt | EBI | MGI Sequence Detail 825 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000017152 ubiquitin carboxyl-terminal hydrolase 16
    (term hierarchy)
  • EC
    3.4.19.12
  • InterPro Domains
    IPR038765 Papain-like cysteine peptidase superfamily
    IPR001394 Peptidase C19, ubiquitin carboxyl-terminal hydrolase
    IPR050185 Ubiquitin carboxyl-terminal hydrolase
    IPR030849 Ubiquitin carboxyl-terminal hydrolase 16
    IPR050164 Ubiquitin carboxyl-terminal hydrolases
    IPR018200 Ubiquitin specific protease, conserved site
    IPR028889 Ubiquitin specific protease USP, catalytic domain
    IPR013083 Zinc finger, RING/FYVE/PHD-type
    IPR001607 Zinc finger, UBP-type
  • GlyGen
    Q99LG0 1 site, 1 O-linked glycan (1 site)
Molecular
Reagents
less
  • All nucleic 119
    cDNA 115
    Primer pair 3
    Other 1
    Antibodies 1

    Microarray probesets 4
Other
Accession IDs
less
MGI:1920049, MGI:1923414
References
more
  • Summaries
    All 70
    Developmental Gene Expression 4
    Gene Ontology 11
    Phenotypes 25
  • Earliest
    J:55368 Kubota H, et al., Structures and co-regulated expression of the genes encoding mouse cytosolic chaperonin CCT subunits. Eur J Biochem. 1999 Jun;262(2):492-500
  • Latest
    J:361105 Tateossian H, et al., DYRK1A kinase triplication is the major cause of Otitis Media in Down Syndrome. Elife. 2025;
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory