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Usp16 Gene Detail
Summary
  • Symbol
    Usp16
  • Name
    ubiquitin specific peptidase 16
  • Synonyms
    1200004E02Rik, 2810483I07Rik, 6330514E22Rik, UBP-M
  • Feature Type
    protein coding gene
  • IDs
    MGI:1921362
    NCBI Gene: 74112
  • Gene Overview
    MyGene.info: USP16
Location & Maps
more
  • Sequence Map
    Chr16:87454703-87483517 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      28815 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    USP16, ubiquitin specific peptidase 16
  • Vertebrate Orthologs
    10
  • Human Ortholog
    USP16, ubiquitin specific peptidase 16
    Orthology source: HomoloGene
  • Synonyms
    UBPM, UBP-M
  • Links
    NCBI Gene ID: 10600
    neXtProt AC: NX_Q9Y5T5

  • Chr Location
    21q22.11; chr21:29024617-29054488 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 38183
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: USP16
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 2 alleles in 2 genetic backgrounds
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    11
  • Gene trapped
    3
  • Targeted
    7
  • Transgenic
    1
  • Genomic Mutations
    2 involving Usp16
  • Incidental Mutations
Mice homozygous for a transgenic gene disruption exhibit embryonic lethality at E6.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000026485 VEGA Gene Model | MGI Sequence Detail 28815 C57BL/6J ±  kb
transcript OTTMUST00000065480 VEGA | MGI Sequence Detail 3205 Not Applicable  
polypeptide OTTMUSP00000032641 VEGA | MGI Sequence Detail 825 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    141 from dbSNP Build 142
Protein
Information
less
  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000017152 ubiquitin carboxyl-terminal hydrolase 16
  • EC
  • InterPro Domains
    IPR001394 Peptidase C19, ubiquitin carboxyl-terminal hydrolase
    IPR030849 Ubiquitin carboxyl-terminal hydrolase 16
    IPR018200 Ubiquitin specific protease, conserved site
    IPR028889 Ubiquitin specific protease domain
    IPR013083 Zinc finger, RING/FYVE/PHD-type
    IPR001607 Zinc finger, UBP-type
Molecular
Reagents
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  • All nucleic 116
    cDNA 114
    Primer pair 2

    Microarray probesets 4
Other
Accession IDs
less
MGI:1920049, MGI:1923414
References
more
  • Summaries
    All 40
    Developmental Gene Expression 3
    Gene Ontology 6
    Phenotypes 12
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:225221 Yang W, et al., The histone H2A deubiquitinase Usp16 regulates embryonic stem cell gene expression and lineage commitment. Nat Commun. 2014;5:3818

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory