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Rbm19 Gene Detail
Summary
  • Symbol
    Rbm19
  • Name
    RNA binding motif protein 19
  • Synonyms
    1200009A02Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1921361
    NCBI Gene: 74111
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:120254578-120337036 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 5, 60.58 cM, cytoband F
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    22 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1921361
protein coding gene Chr5:120254530-120337046 (+)
129S1/SvImJ MGP_129S1SvImJ_G0030000
protein coding gene Chr5:123429687-123517966 (+)
A/J MGP_AJ_G0029964
protein coding gene Chr5:118338505-118421107 (+)
AKR/J MGP_AKRJ_G0029903
protein coding gene Chr5:122170715-122253638 (+)
BALB/cJ MGP_BALBcJ_G0029975
protein coding gene Chr5:119764327-119847665 (+)
C3H/HeJ MGP_C3HHeJ_G0029695
protein coding gene Chr5:122703574-122789121 (+)
C57BL/6NJ MGP_C57BL6NJ_G0030430
protein coding gene Chr5:128076136-128161819 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027656
protein coding gene Chr5:113069089-113152164 (+)
CAST/EiJ MGP_CASTEiJ_G0029104
protein coding gene Chr5:121794542-121882621 (+)
CBA/J MGP_CBAJ_G0029663
protein coding gene Chr5:133062688-133145162 (+)
DBA/2J MGP_DBA2J_G0029813
protein coding gene Chr5:118440675-118523909 (+)
FVB/NJ MGP_FVBNJ_G0029769
protein coding gene Chr5:117349431-117433206 (+)
LP/J MGP_LPJ_G0029901
protein coding gene Chr5:123905290-123992345 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0029800
protein coding gene Chr5:137066692-137150176 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0030471
protein coding gene Chr5:121735437-121820502 (+)
PWK/PhJ MGP_PWKPhJ_G0028817
protein coding gene Chr5:117186820-117270494 (+)
SPRET/EiJ MGP_SPRETEiJ_G0028656
protein coding gene Chr5:119383421-119478301 (+)
WSB/EiJ MGP_WSBEiJ_G0029179
protein coding gene Chr5:122323275-122408337 (+)



Homology
more
  • Human Ortholog
    RBM19, RNA binding motif protein 19
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RBM19, RNA binding motif protein 19
  • Synonyms
    Mrd1
  • Links
    NCBI Gene ID: 9904
    neXtProt AC: NX_Q9Y4C8
    UniProt: Q9Y4C8

  • Chr Location
    12q24.13-q24.21; chr12:113816738-113966325 (-)  GRCh38

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trap allele exhibit failure to undergo compaction, growth arrest at the morula stage, and apoptosis such that no embryos are observed at E6.5.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 74111 NCBI Gene Model | MGI Sequence Detail 82459 C57BL/6J ±  kb
transcript NM_028762 RefSeq | MGI Sequence Detail 4008 FVB/N  
polypeptide Q8R3C6 UniProt | EBI | MGI Sequence Detail 952 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000031720 probable RNA-binding protein 19
  • PDB
  • InterPro Domains
    IPR012677 Nucleotide-binding alpha-beta plait domain superfamily
    IPR034418 Probable RNA-binding protein 19, RNA recognition motif 1
    IPR034417 Probable RNA-binding protein 19, RNA recognition motif 2
    IPR034419 Probable RNA-binding protein 19, RNA recognition motif 3
    IPR034420 Probable RNA-binding protein 19, RNA recognition motif 4
    IPR034423 Probable RNA-binding protein 19, RNA recognition motif 5
    IPR034421 Probable RNA-binding protein 19, RNA recognition motif 6
    IPR035979 RNA-binding domain superfamily
    IPR000504 RNA recognition motif domain
    IPR003954 RNA recognition motif domain, eukaryote
Molecular
Reagents
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  • All nucleic 59
    cDNA 58
    Primer pair 1

    Microarray probesets 3
Other
Accession IDs
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MGI:2141122
References
more
  • Summaries
    All 40
    Developmental Gene Expression 5
    Gene Ontology 5
    Phenotypes 11
  • Earliest
    J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
  • Latest
    J:293906 van Weerd JH, et al., Trait-associated noncoding variant regions affect TBX3 regulation and cardiac conduction. Elife. 2020 Jul 16;9:e56697

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory