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Parn Gene Detail
Summary
  • Symbol
    Parn
  • Name
    poly(A)-specific ribonuclease (deadenylation nuclease)
  • Synonyms
    1200003I18Rik, DAN
  • Feature Type
    protein coding gene
  • IDs
    MGI:1921358
    NCBI Gene: 74108
  • Gene Overview
    MyGene.info: PARN
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:13537960-13668170 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 16, 9.32 cM, cytoband B1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    756 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1921358
protein coding gene Chr16:13537960-13668199 (-)
129S1/SvImJ MGP_129S1SvImJ_G0022531
protein coding gene Chr16:10506222-10648407 (-)
A/J MGP_AJ_G0022493
protein coding gene Chr16:9934530-10066555 (-)
AKR/J MGP_AKRJ_G0022469
protein coding gene Chr16:10366550-10503579 (-)
BALB/cJ MGP_BALBcJ_G0022497
protein coding gene Chr16:10095044-10230956 (-)
C3H/HeJ MGP_C3HHeJ_G0022264
protein coding gene Chr16:10455846-10596746 (-)
C57BL/6NJ MGP_C57BL6NJ_G0022946
protein coding gene Chr16:10669458-10815639 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020466
protein coding gene Chr16:10030872-10160897 (-)
CAST/EiJ MGP_CASTEiJ_G0021791
protein coding gene Chr16:10460241-10602421 (-)
CBA/J MGP_CBAJ_G0022233
protein coding gene Chr16:11150569-11303890 (-)
DBA/2J MGP_DBA2J_G0022364
protein coding gene Chr16:9934948-10064543 (-)
FVB/NJ MGP_FVBNJ_G0022340
protein coding gene Chr16:9914969-10048291 (-)
LP/J MGP_LPJ_G0022432
protein coding gene Chr16:10429864-10564107 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0022362
protein coding gene Chr16:10798106-10960070 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0022959
protein coding gene Chr16:10343454-10480888 (-)
PWK/PhJ MGP_PWKPhJ_G0021533
protein coding gene Chr16:10189636-10322416 (-)
SPRET/EiJ MGP_SPRETEiJ_G0021361
protein coding gene Chr16:10328124-10463209 (-)
WSB/EiJ MGP_WSBEiJ_G0021839
protein coding gene Chr16:10353777-10491636 (-)



Homology
more
  • Human Ortholog
    PARN, poly(A)-specific ribonuclease
  • Vertebrate Orthologs
    10
  • Human Ortholog
    PARN, poly(A)-specific ribonuclease
    Orthology source: HomoloGene, HGNC
  • Synonyms
    DAN, DKCB6, PFBMFT4
  • Links
    NCBI Gene ID: 5073
    neXtProt AC: NX_O95453
    UniProt: O95453

  • Chr Location
    16p13.12; chr16:14435700-14630277 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 31098
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: PARN
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with human PARN associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000022685 Ensembl Gene Model | MGI Sequence Detail 130211 C57BL/6J ±  kb
transcript ENSMUST00000058884 Ensembl | MGI Sequence Detail 2906 Not Applicable  
polypeptide ENSMUSP00000055969 Ensembl | MGI Sequence Detail 624 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 115
    cDNA 115

    Microarray probesets 3
References
more
  • Summaries
    All 36
    Developmental Gene Expression 2
    Gene Ontology 6
    Phenotypes 6
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:188119 Lee JE, et al., The PARN Deadenylase Targets a Discrete Set of mRNAs for Decay and Regulates Cell Motility in Mouse Myoblasts. PLoS Genet. 2012 Aug;8(8):e1002901

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory