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Gga2 Gene Detail
Summary
  • Symbol
    Gga2
  • Name
    golgi associated, gamma adaptin ear containing, ARF binding protein 2
  • Synonyms
    1200007E24Rik, mKIAA1080
  • Feature Type
    protein coding gene
  • IDs
    MGI:1921355
    NCBI Gene: 74105
  • Gene Overview
    MyGene.info: GGA2
Location & Maps
more
  • Sequence Map
    Chr7:121986722-122021222 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      34501 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 65.21 cM, cytoband F3
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    GGA2, golgi associated, gamma adaptin ear containing, ARF binding protein 2
  • Vertebrate Orthologs
    8
  • Human Ortholog
    GGA2, golgi associated, gamma adaptin ear containing, ARF binding protein 2
    Orthology source: HGNC, HomoloGene
  • Synonyms
    VEAR
  • Links
    NCBI Gene ID: 23062
    neXtProt AC: NX_Q9UJY4

  • Chr Location
    16p12; chr16:23463542-23510494 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotypes from 2 alleles in 3 genetic backgrounds
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trapped allele exhibit complete embryonic lethality. Mice homozygous for a different gene trapped allele show decreased birth weight, hypoglycemia and partial neonatal lethality, with all remaining mice dying within the first three weeks of life.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000025491 VEGA Gene Model | MGI Sequence Detail 34501 C57BL/6J ±  kb
transcript OTTMUST00000062741 VEGA | MGI Sequence Detail 4915 Not Applicable  
polypeptide OTTMUSP00000030989 VEGA | MGI Sequence Detail 603 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    169 from dbSNP Build 142
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000007953 ADP-ribosylation factor-binding protein GGA2
  • InterPro Domains
    IPR008152 Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain
    IPR008153 Clathrin adaptor, gamma-adaptin, appendage
    IPR013041 Coatomer/clathrin adaptor appendage, Ig-like subdomain
    IPR008942 ENTH/VHS
    IPR004152 GAT domain
    IPR002014 VHS domain
Molecular
Reagents
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  • All nucleic 117
    cDNA 115
    Primer pair 1
    Other 1

    Microarray probesets 3
References
more
  • Summaries
    All 36
    Developmental Gene Expression 3
    Gene Ontology 5
    Phenotypes 7
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:211200 Doray B, et al., Impact of genetic background on neonatal lethality of Gga2 gene-trap mice. G3 (Bethesda). 2014 May;4(5):885-90

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory