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Npl
Gene Detail
Symbol

Name
ID
Npl
N-acetylneuraminate pyruvate lyase
MGI:1921341
Synonyms
0610033B02Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 1
65.38 cM, cytoband G2
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr1:153503015-153550045 bp, - strand
From VEGA annotation of GRCm38

  47031 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:12533  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

Protein SuperFamily: dihydrodipicolinate synthase
Gene Tree: Npl

Human
homologs
Human Homolog NPL, N-acetylneuraminate pyruvate lyase (dihydrodipicolinate synthase)
NCBI Gene ID 80896
neXtProt AC  NX_Q9BXD5
Human Synonyms  C112, C1orf13, NAL, NPL1
Human Chr (Location)  1q25; chr1:182789449-182830384 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(45) : Gene trapped(43) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutation of this gene results in increased serum cholesterol levels and immunological abnormalities.
 
Interactions
Npl interacts with 65 markers (Mir23b, Mir24-1, Mir24-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (10 annotations)
Process carbohydrate metabolic process, metabolic process, ...
Component cytoplasm
Function catalytic activity, lyase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (100)    Tissues (99)    Images (2)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 100
cDNA source data(7)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(10) cDNA(9) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000049716 (Evidence)
Ensembl Gene ModelENSMUSG00000042684 (Evidence)
Entrez Gene74091 (Evidence)
DFCITC1578705
DoTSDT.94293715, DT.531403
NIA Mouse Gene IndexU021903
EC4.1.3.3
Consensus CDS ProjectCCDS15374.1
International Mouse Knockout Project StatusNpl
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000049716 VEGA Gene Model | MGI Sequence Detail 47031 C57BL/6J ±  kb
transcript OTTMUST00000126636 VEGA | MGI Sequence Detail 1735 Not Applicable 
polypeptide OTTMUSP00000068454 VEGA | MGI Sequence Detail 320 Not Applicable 

For the selected sequences
All sequences(21) RefSeq(2) UniProt(1)
Polymorphisms
SNPs within 2kb(340 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013785 Aldolase-type TIM barrel
InterPro IPR002220 Dihydrodipicolinate synthetase-like
Protein Ontology PR:000011368 N-acetylneuraminate lyase
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:202156 Xiao S, et al., Progesterone receptor-mediated regulation of N-acetylneuraminate pyruvate lyase (NPL) in mouse uterine luminal epithelium and nonessential role of NPL in uterine function. PLoS One. 2013;8(5):e65607
All references(39)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory