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Npl
Gene Detail
 Symbol
Name
ID
Npl
N-acetylneuraminate pyruvate lyase
MGI:1921341
Synonyms 0610033B02Rik
Feature Type protein coding gene
Genetic Map
Chromosome 1
65.38 cM, cytoband G2
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr1:153503016-153549714 bp, - strand
From NCBI annotation of GRCm38

  46699 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:12533  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Protein SuperFamily: dihydrodipicolinate synthase
Gene Tree: Npl

Human
homologs
Human Homolog NPL, N-acetylneuraminate pyruvate lyase (dihydrodipicolinate synthase)
NCBI Gene ID 80896
neXtProt AC  NX_Q9BXD5
Human Synonyms  C112, C1orf13, NAL, NPL1
Human Chr (Location)  1q25; chr1:182789449-182830384 (+)  GRCh38
Alleles
and
phenotypes
All alleles(45) : Gene trapped(43) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutation of this gene results in increased serum cholesterol levels and immunological abnormalities.
 
Gene Ontology
(GO)
classifications
All GO classifications: (10 annotations)
Process carbohydrate metabolic process, metabolic process, ...
Component cytoplasm
Function catalytic activity, lyase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (100)    Tissues (99)    Images (2)
Theiler Stages: 20, 21, 22, 24, 26, 28
Assay TypeResults
RNA in situ 100
cDNA source data(7)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(10) cDNA(9) Primer pair(1)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000042684 (Evidence)
Entrez Gene74091 (Evidence)
DFCITC1578705
DoTSDT.531403, DT.94293715
NIA Mouse Gene IndexU021903
EC4.1.3.3
Consensus CDS ProjectCCDS15374.1
International Mouse Knockout Project StatusNpl
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 74091 NCBI Gene Model | MGI Sequence Detail 46699 C57BL/6J ±  kb
transcript NM_028749 RefSeq | MGI Sequence Detail 1403 C57BL/6 
polypeptide Q9DCJ9 UniProt | EBI | MGI Sequence Detail 320 Not Applicable 

For the selected sequences
All sequences(17) RefSeq(2) UniProt(1)
Polymorphisms SNPs within 2kb(338 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013785 Aldolase-type TIM barrel
InterPro IPR002220 Dihydrodipicolinate synthetase-like
Protein Ontology PR:000011368 N-acetylneuraminate lyase
Graphical View of Protein Domain Structure
References (Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:202156 Xiao S, et al., Progesterone receptor-mediated regulation of N-acetylneuraminate pyruvate lyase (NPL) in mouse uterine luminal epithelium and nonessential role of NPL in uterine function. PLoS One. 2013;8(5):e65607
All references(38)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory