Cep350 MGI Mouse Gene Detail - MGI:1921331

Symbol

Cep350
Name

centrosomal protein 350
Synonyms

4933409L06Rik, 6430546F08Rik

Feature Type

protein coding gene
IDs

MGI:1921331
NCBI Gene: 74081
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr1:155720710-155849001 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 67.64 cM
Mapping Data

2 experiments

SNPs within 2kb

1248 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1921331	protein coding gene	Chr1:155720710-155849001 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0016617	protein coding gene	Chr1:160786868-160927503 (-)
A/J	MGP_AJ_G0016598	protein coding gene	Chr1:154343172-154468934 (-)
AKR/J	MGP_AKRJ_G0016564	protein coding gene	Chr1:159071659-159200590 (-)
BALB/cJ	MGP_BALBcJ_G0016559	protein coding gene	Chr1:154845674-154972881 (-)
C3H/HeJ	MGP_C3HHeJ_G0016383	protein coding gene	Chr1:159197195-159323500 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0017020	protein coding gene	Chr1:166303235-166441746 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014729	protein coding gene	Chr1:146558719-146690470 (-)
CAST/EiJ	MGP_CASTEiJ_G0015963	protein coding gene	Chr1:158730413-158862986 (-)
CBA/J	MGP_CBAJ_G0016358	protein coding gene	Chr1:172157544-172294602 (-)
DBA/2J	MGP_DBA2J_G0016464	protein coding gene	Chr1:153309428-153435970 (-)
FVB/NJ	MGP_FVBNJ_G0016462	protein coding gene	Chr1:151770088-151895994 (-)
LP/J	MGP_LPJ_G0016535	protein coding gene	Chr1:161936380-162067272 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0016487	protein coding gene	Chr1:179753200-179883847 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0017056	protein coding gene	Chr1:158874991-159003096 (-)
PWK/PhJ	MGP_PWKPhJ_G0015749	protein coding gene	Chr1:152377457-152504715 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0015536	protein coding gene	Chr1:157615262-157750556 (-)
WSB/EiJ	MGP_WSBEiJ_G0016025	protein coding gene	Chr1:158961827-159098869 (-)

Human Ortholog

CEP350, centrosomal protein 350

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CEP350, centrosomal protein 350
Synonyms

CAP350, GM133
Links

HGNC:24238

NCBI Gene ID: 9857

neXtProt AC: NX_Q5VT06

UniProt: Q5VT06
Chr Location

1q25.2; chr1:179954674-180114880 (+) GRCh38

MGI Vertebrate Homology

Cep350 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: CEP350
Gene Tree

Cep350

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
10 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

13
Chemically induced (other)

2
Endonuclease-mediated

3
Gene trapped

6
Targeted

2
Genomic Mutations

2 involving Cep350
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

112 strains or lines available

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All GO Annotations

13
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

711
Tissues

5
cDNA Data

103
Literature Summary

2

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase cep350

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All Sequences

68
RefSeq

20
UniProt

4
CCDS

CCDS48400.1

Ensembl

ENSMUSG00000033671 (Evidence)
NCBI Gene

74081

			Length	Strain/Species	Flank
genomic	74081	NCBI Gene Model \| MGI Sequence Detail	128292	C57BL/6J	± kb
transcript	NM_001039184	RefSeq \| MGI Sequence Detail	13238	C57BL/6
polypeptide	E9Q309	UniProt \| EBI \| MGI Sequence Detail	3095	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000005350 centrosome-associated protein 350

(term hierarchy)
InterPro Domains

IPR000938 CAP Gly-rich domain

IPR036859 CAP Gly-rich domain superfamily

IPR028750 Centrosome-associated protein 350/Coiled-coil domain-containing protein 187

IPR025486 Domain of unknown function DUF4378

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All nucleic 104

cDNA 103

Primer pair 1

Microarray probesets 6

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MGI:2442897

Summaries

All 39

Developmental Gene Expression 2

Gene Ontology 7

Phenotypes 10
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:237484 Weidemann M, et al., CFAP157 is a murine downstream effector of FOXJ1 that is specifically required for flagellum morphogenesis and sperm motility. Development. 2016 Dec 15;143(24):4736-4748

TSS for Cep350:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr14379	Chr1:155849101-155849118 (-)	-109 bp
Tssr14378	Chr1:155848951-155849005 (-)	23 bp
Tssr14377	Chr1:155848919-155848950 (-)	66 bp
Tssr14376	Chr1:155823460-155823465 (-)	25,538 bp
Tssr14375	Chr1:155737160-155737175 (-)	111,833 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23