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Syce1
Gene Detail
Symbol

Name
ID
Syce1
synaptonemal complex central element protein 1
MGI:1921325
Synonyms
4933406J07Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 7
85.96 cM, cytoband F5
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr7:140777229-140787854 bp, - strand
From NCBI annotation of GRCm38

  10626 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:77044  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

HCOP human homology predictions: SYCE1
Gene Tree: Syce1

Human
homologs
SYCE1, synaptonemal complex central element protein 1
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 93426
neXtProt AC: NX_Q8N0S2

Human Synonyms: C10orf94, CT76

Human Chr (Location): 10q26.3; chr10:133553900-133568291 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Gene trapped(1) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null allele exhibit small ovaries and small testes, severe defects in gametogenesis, and infertility in both sexes. Meiosis is arrested, homologous chromosomes fail to synapse, and meiotic double-strand breaks are formed but are notefficiently repaired.
 
Phenotype Images(2)
Interactions
Syce1 interacts with 72 markers (Mir1a-1, Mir1a-2, Mir22, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (13 annotations)
Process cell cycle, cell division, ...
Component central element, chromosome, ...
Function protein binding
External Resources: FuncBase
Expression
Literature Summary: (8 records)
Data Summary: Results (23)    Tissues (11)    Images (1)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 2
Western blot 4
RT-PCR 17
cDNA source data(16)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(18) cDNA(16) Primer pair(2)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000025480 (Evidence)
Entrez Gene 74075 (Evidence)
UniGene 46102
DFCI TC1582631
DoTS DT.50315012
NIA Mouse Gene Index U029432
Consensus CDS Project CCDS52436.1
International Mouse Phenotyping Consortium Status Syce1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 74075 NCBI Gene Model | MGI Sequence Detail 10626 C57BL/6J ±  kb
transcript NM_001143765 RefSeq | MGI Sequence Detail 1462 C57BL/6 
polypeptide Q9D495 UniProt | EBI | MGI Sequence Detail 329 Not Applicable 

For the selected sequences
All sequences(15) RefSeq(2) UniProt(1)
Polymorphisms
SNPs within 2kb(82 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR026676 Synaptonemal complex central element protein 1
Protein Ontology PR:000015859 synaptonemal complex central element protein 1
Graphical View of Protein Domain Structure
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:211663 Fukuda T, et al., STAG3-mediated stabilization of REC8 cohesin complexes promotes chromosome synapsis during meiosis. EMBO J. 2014 Jun 2;33(11):1243-55
All references(38)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory