Plce1
Gene Detail

Symbol Name ID

Plce1 phospholipase C, epsilon 1 MGI:1921305

Synonyms

4933403A21Rik, PLCepsilon

Feature Type

protein coding gene

Genetic Map

Chromosome 19

33.16 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr19:38524197-38785098 bp, + strand From Ensembl annotation of GRCm38   260902 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:9478  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 zebrafish

Gene Tree: Plce1

Human homologs

Human Homolog		PLCE1, phospholipase C, epsilon 1
NCBI Gene ID		51196
neXtProt AC		NX_Q9P212
Human Synonyms		NPHS3, PLCE, PPLC
Human Chr (Location)		10q23; chr10:95753746-96088149 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human PLCE1

Alleles and phenotypes

All alleles(5) : Targeted(2) Gene trapped(3)
 

Homozygous mutation of this gene results in a congenital semilunar valvulogenesis defect which causes regurgitation and stenosis, and decreased incidence of induced skin tumors. Another mutant exhibits decreased cardiac contraction and increased hypertrophy in response to chronic stress.

 

Gene Ontology (GO) classifications

All GO classifications: (32 annotations)

Process	activation of MAPK activity, glomerulus development, ...
Component	cytoplasm, cytosol, ...
Function	calcium ion binding, enzyme binding, ...

External Resources: FuncBase

Expression

Literature Summary: (6 records)
Data Summary: Results (116)    Tissues (109)    Images (6)
Theiler Stages: 17, 22, 23, 24, 26, 28

Assay Type	Results
RNA in situ	104
RT-PCR	12

cDNA source data(11)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(13) cDNA(11) Primer pair(1) Other(1)
Microarray probesets(4)

Other database links

Ensembl Gene Model	ENSMUSG00000024998 (Evidence)
Entrez Gene	74055 (Evidence)
DoTS	DT.101735386, DT.40175457, DT.87063310, DT.91394040, DT.94313635
NIA Mouse Gene Index	U019426, U333857
EC	3.1.4.11
Consensus CDS Project	CCDS37973.1
International Mouse Knockout Project Status	Plce1

Sequences

Length	Strain/Species
genomic	ENSMUSG00000024998	Ensembl Gene Model | MGI Sequence Detail	260902	C57BL/6J
transcript	ENSMUST00000169713	Ensembl | MGI Sequence Detail	9507	Not Applicable
polypeptide	ENSMUSP00000130604	Ensembl | MGI Sequence Detail	2282	Not Applicable

All sequences(34) RefSeq(2) UniProt(2)

Polymorphisms

SNPs(1421 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000008	C2 calcium-dependent membrane targeting
InterPro	IPR008973	C2 calcium/lipid-binding domain, CaLB
InterPro	IPR018029	C2 membrane targeting protein
InterPro	IPR011992	EF-hand-like domain
InterPro	IPR001895	Guanine-nucleotide dissociation stimulator CDC25
InterPro	IPR001192	Phosphoinositide phospholipase C
InterPro	IPR000909	Phospholipase C, phosphatidylinositol-specific , X domain
InterPro	IPR001711	Phospholipase C, phosphatidylinositol-specific, Y domain
InterPro	IPR015359	Phospholipase C, phosphoinositol-specific, EF-hand-like
InterPro	IPR017946	PLC-like phosphodiesterase, TIM beta/alpha-barrel domain
InterPro	IPR000159	Ras-association
InterPro	IPR023578	Ras guanine nucleotide exchange factor, domain
Protein Ontology	PR:000012835	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1

References

(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:171257 Oka M, et al., Phospholipase Cvarepsilon has a crucial role in ultraviolet B-induced neutrophil-associated skin inflammation by regulating the expression of CXCL1/KC. Lab Invest. 2011 May;91(5):711-8
All references(42)